The Department of Surgery at the University of Texas Medical School at Houston
Department of Surgery
photo courtesy JBJ

Faculty Biography

Department of Surgery
Division of General Surgery


Tien C. Ko, M.D.

Professor of Surgery
Vice Chairman for Harris County Hospital District
Chief of Surgery at Lyndon B. Johnson General Hospital

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EDUCATION

Undergraduate Education

1982 University of California, Los Angeles, B.S. (Biochemistry)

Graduate Education

1986 School of Medicine, University of California, Los Angeles, (M.D.)

Postgraduate Training

1986-1987 Intern/Resident I in General Surgery, Loyola University Medical Center, Maywood, Illinois
1987-1991 Resident II through V in General Surgery, Loyola University Medical Center, Maywood, Illinois
1991-1993 Research Fellow in Department of Surgery, The University of Texas Medical Branch, Galveston, Texas
1998-1999 Postdoctoral Fellow in Department of Growth and Development, University of California, San Francisco, San Francisco, California

LICENSURE

inactive Illinois License Registration No. 036-077096
1993-present Texas License No. J4881

ACADEMIC APPOINTMENTS

1991-1993 Assistant Instructor in the Department of Surgery, The University of Texas Medical Branch, Galveston, Texas
1993-1999
Assistant Professor in Departments of Surgery and Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas
1998-1999
Visiting Assistant Professor in the Department of Growth and Development, University of California, San Francisco, San Francisco, California
1999-2007
Associate Professor in Departments of Surgery and Biochemistry and Molecular Biology, Scientist of the Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas
2001-2007
Chela and Jimmy Storm Distinguished Professorship in Surgical Research in Department of Surgery, The University of Texas Medical Branch, Galveston, Texas
2003-2007
Director of Real-Time PCR Core Facility, the Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas
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HOSPITAL APPOINTMENTS
1993-present
The University of Texas Medical Branch – active staff
2/01/07-present
Harris County Hospital District – active staff
3/02/07-present
Memorial Hermann Hospital-TMC – active staff

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PROFESSIONAL ORGANIZATIONS

LOCAL:

Singleton Surgical Society
Audit Committee (1997-2003)
President-Elect (2002-2003)
Constitution & Bylaws Committee, Chair (2002-2003)
Board of Directors (2002-present)
President (2003-2004)
Program Committee, Chair (2003-2004)
Financial Advisory Committee, Chair (2003-2004)
Local Arrangement Committee (2003-2004)
Nominating Committee, Chair (2004-2005)
Planning Committee, Chair (2004-2005)
Financial Advisory Committee (2004-2005)

REGIONAL:

Southern Surgical Association – elected 2003
Texas Surgical Society - elected 2002

NATIONAL:

American Association for Cancer Research – elected 1994

American Board of Surgery, Diplomat
Examination Consultant to the In-Training Examination Committee (2006-2007)

American College of Surgeons, Fellow – elected 1996
Committee for the Forum on Fundamental Surgical Problems (2004-present)

American Gastroenterology Association – elected 1995
Abstract Review Committee for Digestive Disease Week
(2004-2007)

Alpha Omega Alpha Medical Honor Society – elected 1986

American Society for Cell Biology - elected 1994

Association for Academic Surgery

Membership Committee (1995-1997)
Nominating Committee (1997-1998)
Recorder (1998-2000)
Program Committee, Chair (1998-2000)
Executive Council (1998-2006)
President-elect (2000-2001)
President (2001-2002)
Nominating Committee, Chair (2001-2002)

Association for Academic Surgery

AAS/SUS Joint Task Force Committee (2001-2004)

Pancreas Club

Phi Delta Epsilon

Phi Beta Kappa Honor Society- elected 1982

Society of University Surgeons – elected 1996
Committee on Surgical Education (1998-2000)
Audit Committee (2002-2003)
Ad-Hoc Membership Task Force (2005)

Society for Surgery of the Alimentary Tract – elected 1997

Surgical Biology Club I - elected 1998

HONORS AND AWARDS

Bank of America Achievement Award (1978)
Alumni Scholarship, UCLA (1978-1982)
National Dean’s List (1980)
Max Dunn Prize for Biochemistry, UCLA (1982)
Highest Honors in Biochemistry, UCLA (1982)
College Honors, UCLA (1982)
Regents Scholarship, UCLA School of Medicine (1982-1986)
Graduated Summa Cum Laude, UCLA School of Medicine (1986)
Career Development Award, Society for Surgery of the Alimentary Tract (1991-1993)
Clinical Investigator Award, National Institutes of Health (NCI, 1994-1999)
Shipley Award for the best presentation by a new member, Southern Surgical Association (2005)

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EDITORIAL POSITIONS

Editorial Board, Journal of Surgical Research (1998-2000)
Ad Hoc Reviewer: American Journal of Physiology
American Journal of Surgery
Cancer
Cancer Letters
Cancer Research
Digestive Diseases and Science
Gastroenterology
Journal of Parenteral and Enteral Nutrition Surgery

COMMITTEES

SERVICE ON NATIONAL GRANT REVIEW PANELS:

VA Medical Research Service Merit Review Subcommittee for Surgery
(2005-present)
VA Medical Research Service Merit Review Subcommittee for Gastroenterology (2007)

SERVICE ON THE UNIVERSITY OF TEXAS COMMITTEES:

Recruitment Committee for the Sealy Center for Cancer Cell Biology, UTMB (2003-2005)
Gastrointestinal Cancer Interest Group, Sealy Center for Cancer Cell Biology, UTMB (2004-2007)
Sealy Center for Cancer Cell Biology Pre-doctoral Fellowship Committee, UTMB (2005)
Scientific Integrity Committee, UTMB (2005-2007)
Scientific Integrity Committee, UTMB, Chairman (2006-2007)

SERVICE ON THE UNIVERSITY OF TEXAS MEDICAL SCHOOL COMMITTEES:

Admission Committee of UTMB, Ad Hoc Reviewer (1998-2006)
Herman Barnett Award Committee, UTMB (2003-2006)
OSOM Task Force on Evidence Based Practice, UTMB (2006)
Publications Services Committee, Department of Surgery, Chair (1997-1998)
Resident Education Committee, Department of Surgery (1994-2007)
Computer Committee, Department of Surgery (1997-2007)
Research Committee, Department of Surgery (1997-2007)
Tenure Review Committee, Department of Surgery (2001-2007)
Ad Hoc Committee for Appointment and Tenure, Department of Surgery (2006)
Graduate Student Education Committee (2007-2010)
Research Committee (2007-2010)

SERVICE ON GRADUATE SCHOOL COMMITTEES:

Cell Biology of Tissues Task Force, Cell Biology Graduate Program, UTMB (2005)

SERVICE TO UTMSH AFFILIATED HOSPITAL COMMITTEES:

UT-MED Access Task Force (1995-1996)
Operative & Other Invasive Procedures Committee of UTMB Medical Staff (1995-1997)
UT-MED Managed Care Committee (1996-1998)
Physician Health and Rehabilitation Committee of UTMB Medical Staff (1996-2007)
Operative & Other Invasive Procedures Committee of UTMB Medical Staff (2003-2007)
Executive Medical Board of the Harris County Hospital District (2007-present)
Executive Committee of Lyndon B. Johnson General Hospital (2007-present)
Perioperative Executive Committee of Lyndon B. Johnson General Hospital (2007-present)
Operative Room Committee of Lyndon B. Johnson General Hospital (2007-present)
Pre-Op Clinic Task Force of Lyndon B. Johnson General Hospital (2007-present)
Patient Access Committee of Harris County Hospital District (2007-present)
Cancer Committee of Harris County Hospital District (2007-present)

SPONSORSHIP OF POSTDOCTORAL FELLOWS:

Harry T. Papaconstantinou, M.D. (1997-1999)
Xiang Ying Xue, M.D. (1997-1999)
Yanna Cao, M.D. (1999-2002)
Yan Liu, Ph.D. (2001-2003)
Michele I. Slogoff, M.D. (2001-2003)
Fazhi Li, M.D. (2001-2004)
Khoa A. Nguyen, Ph.D. (2003-2005)
Junmei Zhao, Ph.D. (2005-2006)
Weili Zhang, M.D., Ph.D. (2005-present)
Guo-hua Zhang, Ph.D. (2006-present)
Xianghua Liu, Ph.D. (2007-present)

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POST-GRADUATE COURSES TAUGHT

MEDICAL SCHOOL:

“Colorectal neoplasia,” GI Pathophysiology Conference (1996)
“Small bowel obstruction,” Department of Surgery GI Case Conference (1997)
“Colorectal diseases,” Department of Surgery, Third Year Junior Surgical Clerkship Core Lecture (1997-2000)
Advance Trauma Life Support Student Course (1997-2007)
“Postoperative complications,” Department of Surgery, Third Year Junior Surgical Clerkship Core Lecture (2000-2002)
“Abdominal Workshop,” Second Year Medical Course “the Practice of Medicine 2” (2000-2007)
“GI hormones and the coordination of digestion,” Second Year Medical Course “Gastrointestinal Nutrition” (2002-2007)

GRADUATE SCHOOL:

“Cyclins as oncogenes,” Graduate Course “Oncogenes” (1995)
“Oncogenes in intestinal cell cycle regulation,” Graduate Course “Oncogenes” (1997)
“Cell signaling,” M.D.-Ph.D. Supplement Graduate Course “Molecules, cells and tissues” (1999)
“Cell proliferation,” M.D.-Ph.D. Supplement Graduate Course “Molecules, cells and tissues” (2000)
“Cyclins, Cdks and cell cycle control,” Small-Group Research Paper Discussion for Graduate Course “Cell biology” (2000-2001)
“Neoplasia,” M.D.-Ph.D. Pathobiology Supplementation Course
(2003-2004)
“GI hormones and the coordination of digestion,” GI Pathophysiology Conference (2004)
“Cancer,” M.D.-Ph.D. Supplement Graduate Course “Molecules, cells and tissues” (2003-2007)
Cell Biology Small-Group Paper Discussion (BBSC 6402, 2003-2007)

NATIONAL:

Mock Study Section Faculty, American College of Surgeons’ Young Surgical Investigator Conference, Chantilly, VA (1998)
“Molecular biology techniques,” Fundamentals of Surgical Research Course, Philadelphia, PA (1999)
Grantsmanship Faculty and Mock Study Section Faculty, American College of Surgeons’ Young Surgical Investigator Conference, Chantilly, VA (2000)
“Molecular biology techniques,” Fundamentals of Surgical Research Course, Tampa, FL (2000)
“Designing an experiment,” Fundamentals of Surgical Research Course, Milwaukee, WI (2001)
“Researching and writing a scientific manuscript,” Fundamentals of Surgical Research Course, Boston, MA (2002)

PUBLICATIONS

  1. Ko, T.C., Bertram, M.F., and Prinz, R.A., Castelli, M., Djuricin, G., and Jacobs, H.K.: Effect of somatostatin analogue and cholecystokinin receptor antagonist on bile-induced acute canine pancreatitis. Am. Surgeon 58:213-219, 1992.
  2. Ko, T.C., Flisak, M., and Prinz, R.A.: Selective intra-arterial methylene blue injection: a novel method of localizing gastrinoma. Gastroenterology 102:1062-1064, 1992.
  3. Chung, D.H., Evers, B.M., Townsend, C.M. Jr., Herndon, D.N., Ko, T.C., Uchida, T., and Thompson, J.C.: Cytokine regulation of gut ornithine decarboxylase gene expression and enzyme activity. Surgery 112:364-369, 1992.
  4. Fedorak, I.J., Ko, T.C., Djuricin, G., McMahon, M., Thompson, K., and Prinz, R.A.: Secondary pancreatic infections: are they distinct clinical entities? Surgery 112:824-831, 1992.
  5. Ko, T.C., Beauchamp, R.D., Ishizuka, J., Townsend, C.M. Jr., and Thompson, J.C.: Mechanism of action of transforming growth factor-beta on rat jejunal cells. Surg. Forum 43:135-137, 1992.
  6. Beauchamp, R.D., Ko, T.C., Townsend, C.M. Jr., and Thompson, J.C.: Transforming growth factor-beta stimulates ornithine decarboxylase in murine fibroblasts. Surg. Forum 43:670-672, 1992.
  7. Fedorak, I.J., Ko, T.C., Gordon, D., Flisak, M., and Prinz, R.A.: Localization of islet cell tumors of the pancreas: a review of current techniques. Surgery 113:242-249, 1993.
  8. Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation. Surgery 114:147-154, 1993.
  9. Prinz, R.A., Ko, T.C., Maltz, S.B., Reynes, C.J., Marsan, R.E., and Freeark, R.J.: Common bile duct obstruction by free floating tumor. H. P. B. Surg. 6:319-323, 1993.
  10. Henderson, A.M., Beauchamp, R.D., Ko, T.C., Townsend, C.M. Jr., and Thompson J.C.: Lipopolysaccharide (LPS) induces AP-1 nuclear transcription factor in mouse liver. Surg. Forum 44:64-66, 1993.
  11. Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Transforming growth factor-beta inhibits rat intestinal cell growth by regulating cell cycle specific gene expression. Am. J. Surg. 167:14-20, 1994.
  12. Ko, T.C., Sheng, H.M., Reisman, D., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor-beta1 inhibits cyclin D1 expression in intestinal epithelial cells. Oncogene 10:177-184, 1995.
  13. Upp, J.R. Jr., Ko, T.C., Townsend, C.M. Jr., Thompson, J.C., and Beauchamp, R.D.: Glutamine regulates cell cycle protein expression for intestinal cell growth. Surg. Forum 46:177-179, 1995.
  14. Ko, T.C., Pan, F., Brown, D.B., Thompson, E.A., and Beauchamp, R.D.: Intracellular regulation of intestinal cell proliferation: a study using microinjection technology. Surg. Forum 46:182-184, 1995.
  15. Beauchamp, R.D., Sheng, H.M., Shao, J.Y., Thompson, E.A., and Ko, T.C.: Intestinal cell cycle regulation: interactions of cyclin D1, Cdk4 and p21Cip1. Ann. Surg. 223:620-628, 1996.
  16. Evers, B.M., Ko, T.C., Li, J., and Thompson, E.A.: Cell cycle protein suppression and p21 induction in differentiating Caco-2 cells. Am. J. Physiol. 271:G722-G727, 1996.
  17. Allen, G.E., Walser, E., Morgan, R.A., Imbing, F., Dy, E., Adesokan, A., Ko, T.C.: Jejunal arteriovenous malformation: preoperative superselective angiography and intraoperative localization using methylene blue. J. Interventional. Radiol. 12:7-11, 1997.
  18. Iseki, H., Ko, T.C., Xue, X.Y., Seapan, A., Hellmich, M.R., and Townsend, C.M. Jr.: Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells. Surgery 122:187-195, 1997.
  19. Ko, T.C., Seapan, A., Xue, X.Y., and Townsend, C.M. Jr.: Cyclin-dependent kinase 2 is required for G1/S transition in rat intestinal epithelial cells. Surg. Forum 48:217-218, 1997.
  20. Matin, S., Ikeda, H., Guo, Y.-S., Wolf, S.E., Ko, T.C., Rajaraman, S., Herndon, D.N., and Thompson, J.C.: Burn-induced stimulation of apoptosis-related genes in rat small bowel. Surg. Forum 48:221-223, 1997.
  21. Wu, G.-F., Fan, R.S., Li, W.-H., Ko, T.C., and Brattain, M.G.: Modulation of cell cycle control by vitamin D3 and its analogue, EB1089, in human breast cancer cells. Oncogene 15:1555-1563, 1997.
  22. Ehrenfried, J.A., Ko, T.C., Thompson, E.A., and Evers, B.M.: Cell cycle mediated regulation of hepatic regeneration. Surgery 122:927-935, 1997.
  23. Ko, T.C.: Postoperative surveillance of colorectal cancer. Curr Surg 54:470-473, 1997.
  24. Gong, J.G., Ko, T.C., and Brattain, M.G.: Disruption of fibronectin binding to the ?5?1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase. J. Biol. Chem. 273:1662-1669, 1998.
  25. Iseki, H., Ko, T.C., Xue, X.Y., Seapan, A., and Townsend, C.M. Jr.: A novel strategy for inhibiting growth of human pancreatic cancer cells by blocking cyclin-dependent kinase activity. J. Gastrointest Surg. 2:36-43, 1998.
  26. Ko, T.C., Yu, W.S., Sakai, T., Sheng, H.M., Shao, J., Beauchamp, R.D., and Thompson, E.A.: TGF-beta1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression. Oncogene 16:3445-3454, 1998.
  27. Papaconstantinou, H.T., Hwang, K.O., Rajaraman, S., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamine deprivation induces apoptosis in intestinal epithelial cells. Surgery 124:152-160, 1998.
  28. Litvak, D.A., Evers, B.M., Hwang, K.O., Hellmich, M.R., Ko, T.C., and Townsend, C.M. Jr.: Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21Waf1/Cip1 and p27Kip1. Surgery 124:161-170, 1998.
  29. Papaconstantinou, H.T., Boldogh, I., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamine deprivation decreases glutathione levels in intestinal epithelial cells. Surg. Forum 49:164-166, 1998.
  30. Ding, Q.M., Ko, T.C., and Evers, B.M.: Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of Cdk2 and Cdk4. Am. J. Physiol. 275:C1193-C1200, 1998.
  31. Litvak, D.A., Papaconstantinou, H.T., Ko, T.C., and Townsend, C.M. Jr.: A novel cytotoxic agent for human carcinoid tumors. Surgery 124:1071-1076, 1998.
  32. Papaconstantinou, H.T., Chung, D.H., Townsend, C.M. Jr., and Ko, T.C.: Glutamine-starvation induces mitochondrial damage independent of caspase activation in intestinal epithelial cells. Surg. Forum 50:64-66, 1999.
  33. Wolf, S.E., DebRoy, M.A., Ikeda, H., Jeschke, M.G., Matin, S., Rajaraman, S., Ko, T.C., Englander, E., Norman, J.G., and Thompson, J.C.: Increased small bowel epithelial cell turnover in interleukin-1 receptor knockout mice. Ann. Surg. 232:42-45, 2000.
  34. Papaconstantinou, H.T., Chung, D.H., Zhang, W., Ansari, N.H., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Prevention of mucosal atrophy: the role of glutamine and caspases in apoptosis in intestinal epithelial cells. J. Gastrointest Surg. 4:416-423, 2000.
  35. Yang, L., Yang, J., Venkateswarlu, S., Ko, T.C., and Brattain, M.G.: Autocrine TGFbeta signaling mediates vitamin D3 analog-induced growth inhibition in breast cells. J. Cell. Physiol. 188:383-393, 2001.
  36. Papaconstantinou, H.T., Xie, C., Zhang, W., Ansari, N.H., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: The role of caspases in methotrexate-induced gastrointestinal toxicity. Surgery 130:859-865, 2001.
  37. Ko, T.C., Pan, F., Sheng, H., Brown, D.B., Thompson, E.A., and Beauchamp, R.D.: Cyclin D3 is essential for intestinal epithelial cell proliferation. World J. Surg. 26:812-818, 2002.
  38. Naoum, J.J., Mileski, W.J., Daller, J.A., Gomez, G.A., Gore, D.C., Kimbrough, T.D., Ko, T.C., Sanford, A.P., and Wolf, S.E.: The use of abdominal computed tomography scan decreases the frequency of misdiagnosis in cases of suspected appendicitis. Am. J. Surg. 184:587-589, 2002.
  39. Gong, J., Ammanamanchi, S., Ko, T.C., and Brattain, M.G.: Transforming growth factor beta1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells. Cancer Res. 63:3340-3346, 2003.
  40. Awwad, R.A., Sergina, N., Yang, H., Ziober, B., Willson, J.K.V., Zborowska, E., Humphrey, L.E., Fan, R., Ko, T.C., Brattain, M.G., and Howell, G.M.: The role of transforming growth factor beta in determining growth factor independence. Cancer Res. 63:4731-4738, 2003.
  41. Ammanamanchi, S., Tillekeratne, M.P.M., Ko, T.C., and Brattain, M.G.: Endogenous control of cell cycle progression by autocrine transforming growth factor beta in breast cancer cells. Cancer Res. 64:2509-2515, 2004.
  42. Conery, A.R., Cao, Y., Thompson, E.A., Townsend, C.M. Jr., Ko, T.C., and Luo, K.: Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta-induced apoptosis. Nature Cell Biology 6:366-372, 2004. (Ko, T.C. and Luo, K. co-corresponding authors)
  43. Wang, J., Sergina, N., Ko, T.C., Gong, J., and Brattain, M.G.: Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. J. Biol. Chem. 279:40237-40244, 2004.
  44. Li, F., Cao, Y., Townsend, C.M. Jr., and Ko, T.C.: TGF-beta signaling in colon cancer cells. World J. Surg. 29:306-311, 2005.
  45. Alliston, T., Ko, T.C., Cao, Y., Liang, Y.Y., Feng, X.H., Chang, C., and Derynck, R.: Repression of BMP and Activin-inducible transcription by Evi-1. J. Biol. Chem. 280:24227-24237, 2005. (Ko, T.C. and Alliston, T. co-first authors)
  46. Nguyen, K.A., Cao, Y., Chen, J.R., Townsend, C.M. Jr., and Ko, T.C.: Dietary fiber enhances a tumor suppressor signaling pathway in the gut. Ann. Surg. 243:619-627, 2006
  47. Liu, Y., Chen, L., Ko, T.C., Fields, A.P., and Thompson, E.A.: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. Oncogene 25:3565-3575, 2006.
  48. Cao, Y., Deng, C., Townsend, C.M. Jr., and Ko, T.C.: TGF-beta inhibits AKT-induced transformation in intestinal epithelial cells. Surgery 140:322-329, 2006.
  49. Qiao, J., Kang, J., Ko, T.C., Evers, B.M., and Chung, D.H.: Inhibition of transforming growth factor-beta/Smad signaling by phosphatidylinositol 3-kinase pathway. Cancer Lett. 242:207-214, 2006.
  50. Cao, Y., Chen, L., Zhang, W., Liu, Y., Papaconstantinou, H.T., Bush, C.R., Townsend, C.M. Jr., Thompson, E.A., and Ko, T.C.: Identification of apoptotic genes mediating transforming growth factor (TGF)-beta/Smad3-induced cell death in intestinal epithelial cells using a genomic approach. Am. J. Physiol. 292:G28-G38, 2007.
ABSTRACTS
  1. Abrass, I.B., Ko, T.C., and Scarpace, P.J.: Platelet alpha-adrenergic receptor function in aging. Clin. Res. 32:479A, 1984.
  2. Ko, T.C., Prinz, R.A., Castelli, M., Marks, W., Djuricin, G., Jacobs, H.K., and La Barbara, M.: Effect of SMS 201-295 on bile induced acute canine pancreatitis. Pancreas 4:624, 1989.
  3. Fedorak, I.J., Thompson, K., Djuricin, G., Ko, T.C., and Prinz, R.A.: Are the varieties of pancreatic infection distinct clinical entities? Pancreas 6:699, 1991.
  4. Ko, T.C., Evers, B.M., Chung, D.H., Townsend, C.M. Jr., Carraway, R.E., Uchida, T., and Thompson, J.C.: Xenopsin stimulates small intestinal growth in rats. Gastroenterology 102:A561, 1992.
  5. Ko, T.C., Beauchamp, R.D., Ishizuka, J., Townsend, C.M. Jr., and Thompson, J.C.: Transforming growth factor beta uncouples ornithine decarboxylase activation from DNA synthesis in rat jejunal cells. Regul. Pept. 40:183, 1992.
  6. Zhang, T., Beauchamp, R.D., Ko, T.C., Sheng, H.M., Gomez, G., Townsend, C.M. Jr., Thompson, J.C., and Greeley, G.H. Jr.: Phorbol ester-induced growth inhibition and immediate-early gene expression in a human pancreatic carcinoid cell line. Gastroenterology 104:A466, 1993.
  7. Ko, T.C., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor beta inhibits cyclin D1 induction during G1 phase of the cell cycle. Proc. Am. Assoc. Cancer Res. 35:26, 1994.
  8. Ko, T.C., Beauchamp, R.D., and Thompson, E.A.: Cyclin D1 antisense oligonucleotide inhibits intestinal epithelial cell proliferation. Gastroenterology 106:A243, 1994.
  9. Ko, T.C., Sheng, H.M., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor-beta1 inhibits transcription of cyclin D1 in intestinal epithelial cells. Gastroenterology 106:A244, 1994.
  10. Ko, T.C., Sheng, H.M., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor-beta1 regulation of cyclin D1 in intestinal epithelial cells. Proc. Am. Assoc. Cancer Res. 36:34, 1995.
  11. Ko, T.C., Sheng, H.M., Sheng, G.G., Thompson, E.A., and Beauchamp, R.D.: Effect of fasting and refeeding on cyclin D3 and Cdk4 expression in rat jejunum. Gastroenterology 108:A981, 1995.
  12. Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Glutamine and polyamines promote intestinal cell proliferation by separate intracellular mechanisms. Gastroenterology 108:A1226, 1995.
  13. Ko, T.C., Sheng, H.M., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor-beta1 inhibits G1 cyclin-dependent kinase activities in intestinal epithelial cells. Proc. Am. Assoc. Cancer Res. 37:4, 1996.
  14. Zhang, T., Nanney, L., Ko, T.C., Luongo, C., Lamps, L., DuBois, R.N., and Beauchamp, R.D.: Overexpression of cyclin D1 in intestinal polyposis of Min mice and human familial adenomatous polyposis subjects. Proc. Am. Assoc. Cancer Res. 37:112, 1996.
  15. Ko, T.C., Thompson, J.C., and Thompson, E.A.: Effects of starvation and glutamine on intestinal epithelial cell cycle and Cdk2 activity. Gastroenterology 110:A812, 1996.
  16. Iseki, H., Ko, T.C., Guo, Y.-S., and Townsend, C.M. Jr.: Olomoucine blocks IGF-I-stimulated proliferation and cyclin-dependent kinase activity of human gastric cancer cells. Proc. Am. Assoc. Cancer Res. 38:138, 1997.
  17. Fan, R.S., Ko, T.C., and Brattain, M.G.: Alteration in control of cell cycle transit associated with growth factor independence. Proc. Am. Assoc. Cancer Res. 38:496, 1997.
  18. Gong, J.G., Ko, T.C., and Brattain, M.G.: Stimulation of p21/WAF1 expression by TGF-beta1 in G1 is required for inhibition of cyclin A/CDK2 kinase activity and cell cycle transit. Proc. Am. Assoc. Cancer Res. 38:498, 1997.
  19. Iseki, H., Ko, T.C., Xue, X.Y., and Townsend, C.M. Jr.: A novel strategy to inhibiting growth of human pancreatic cancer cells by blocking cyclin-dependent kinase activity. Gastroenterology 112:A1451, 1997.
  20. Fan, R.S., Ko, T.C., and Brattain, M.G.: Lack of cyclin A kinase activity associated with incomplete pRb phosphorylation and absence of cell cycle progression. Proc Am Assoc Cancer Res 39:255, 1998.
  21. Ding, Q.-M., Ko, T.C., and Evers, B.M.: Differentiation of Caco-2 intestinal cells is associated with G1 arrest and suppression of cyclin-dependent kinase. Gastroenterology 114:A874, 1998.
  22. Ko, T.C., Pan, F., Brown, D.B., Thompson, E.A., and Beauchamp, R.D.: Cyclin D3 is essential for intestinal epithelial cell proliferation. Gastroenterology 114:A899, 1998.
  23. Papaconstantinou, H.T., Powell, S.J., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamate and asparagine protect against the induction of apoptosis in glutamine-deprived intestinal epithelial cells. Gastroenterology 114:A1401, 1998.
  24. DebRoy, M., Wolf, S., Matin, S., Rajaraman, S., Ko, T.C., Norman, J., and Thompson, J.C.: Small bowel epithelial apoptosis is increased in IL-1 receptor knockout mice. Dig. Dis. Sci. 43:1856, 1998.
  25. Papaconstantinou, H.T., Chung, D.H., Zhang, W., Ansari, N.H., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Caspase 2 and 3 modulate glutamine-starvation induced apoptosis in enterocytes. Gastroenterology 116:A1325, 1999.
  26. Wolf, S.E., Papaconstantinou, H., Ko, T.C., Thompson, M., and Thompson, J.C.: Decreased gut epithelial cell viability in burn serum. Gastroenterology 116:A1370, 1999.
  27. Papaconstantinou, H.T., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamine starvation-induced cell cycle arrest is associated with the induction of p21Cip1 and does not require caspase activation. J. Surg. Res. 86:264-265, 1999.
  28. Cao, Y., Xie, C., Yu, W., Townsend, C.M. Jr., Thompson, E.A., and Ko, T.C.: Growth regulation of gut epithelial cells by TGF-beta. J. Surg. Res. 93:339-340, 2000.
  29. Li, F., Cao, Y., Song, D., Townsend, C.M. Jr., and Ko, T.C.: TGF-beta/Smad signaling in colon cancer cells. J. Am. Coll. Surg. 195 (suppl):S14, 2002.
  30. Cao, Y., Liu, Y., Li, F., Song, D., Hellmich, M.R., Mileski, W.J., Townsend, C.M. Jr., and Ko, T.C.: A novel mechanism of repression of TGF-beta signaling in human colon cancers. J. Surg. Res. 107:279, 2002.
  31. Slogoff, M.I., Li, F., Cao, Y., Guo, Y.-S., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Bombesin potentiates transforming growth factor-beta (TGF-beta)-mediated cell death in intestinal epithelial cells. J. Surg. Res. 107:293, 2002.
    Cao, Y., Yu, W., Xie, C., Xue, X.Y., Choy, L., Townsend, C.M. Jr., Thompson, E.A., and Ko, T.C.: Critical role of Smad3 in TGF-beta-mediated apoptosis and growth inhibition in epithelial cells. Mol. Biol. Cell 13 (suppl):16a, 2002.
  32. Liu, Y., Cao, Y., Sambandam, K., Townsend, C.M. Jr., and Ko, T.C.: Identification of alternatively spliced forms of Evi-1 oncogene in human colorectal cancers. Ann. Surg. Oncol. 10 (suppl):S30-S31, 2003.
  33. Li, F., Cao, Y., Townsend, C.M. Jr., and Ko, T.C.: p38 MAPK signaling pathway is involved in transforming growth factor-beta (TGF-beta)/Smad3-induced apoptosis. Gastroenterology 124:A275, 2003.
  34. Cao, Y., Chen, L., Townsend, C.M. Jr., Thompson, E.A., and Ko, T.C.: Identification of apoptotic genes mediating transforming growth factor-beta/Smad3-induced cell death in intestinal epithelial cells using genomic approach. J. Am. Coll. Surg. 197 (suppl):S7, 2003.
  35. Wang, J.J., Sergina, N., Ko, T.C., Gong, J., Wang, X.F., and Brattain, M.G.: Autocrine negative TGF-beta controls cell cycle inhibition through a p21 mediated mechanism. Proc. Am. Assoc. Cancer. Res. 45:79, 2004.
  36. Cao, Y., Li, F., Hellmich, M.R., Guo, Y.-S., Sheng, H.M., Townsend, C.M. Jr., and Ko, T.C.: Transforming growth factor-beta and bombesin synergistically activate cyclooxygenase-2. Proc. Am. Assoc. Cancer. Res. 45:939, 2004.
  37. Cao, Y., Liu, Y., Chen, L., Thompson, E.A., Townsend, C.M. Jr., and Ko, T.C.: Inhibitor of differentiation (Id)-2 is a downstream target gene of transforming growth factor (TGF)-beta in the regulation of apoptosis. Gastroenterology 126:A137, 2004.
  38. Cao, Y., Deng, C., and Ko, T.C.: TGF-beta regulates multiple transcription factors through repression of Id2 for induction of apoptosis in gut epithelial cells. Gastroenterology 128 (suppl 2):A603, 2005.
  39. Nguyen, K.A., Cao, Y., and Ko, T.C.: N-terminal domain of Smad3 plays an important role in TGF-beta-induced apoptosis of gut epithelial cells. Gastroenterology 128 (suppl 2):A605, 2005.
  40. Cao, Y., Townsend, C.M. Jr., and Ko, T.C.: Transforming growth factor-beta (TGF-beta) induces vascular endothelial growth factor (VEGF) and plasminogen activator inhibitor-1 (PAI-1) gene expression through Smad3 transcription factor. J. Am. Coll. Surg. 201 (suppl):S17-S18, 2005.
  41. Cao, Y., Deng, C., Townsend, C.M. Jr., and Ko, T.C.: TGF-beta inhibits AKT-induced transformation in intestinal epithelial cells. J. Surg. Res. 130:192, 2006.
CHAPTERS
  1. Thompson, E.A., Ko, T.C., and Beauchamp, R.D.: TGF-beta inhibition of intestinal epithelial cell proliferation: G1 cyclins, cyclin-dependent kinases, and cyclin kinase inhibitors. In: Vedeckis, W.V. (ed). Hormones and cancer. Birkhauser Boston: Cambridge, MA, 1996, pp.43-71.
  2. Ko, T.C., Bresnahan, W.A., and Thompson, E.A.: Intestinal cell cycle regulation. In: Meijer, L., Guidet, S., and Philippe, M. (eds). Progress in cell cycle research, Vol. 3. Plenum Press: New York, NY, 1997, pp.43-52.
  3. Ko, T.C., and Thompson, J.C.: Effects of aging on gut hormones. In: Greeley, G.H. Jr. (ed). Gastrointestinal Endocrinology. Humana Press, Inc: Totowa, NJ 1999, pp.169-187.
  4. Papaconstantinou, H.T., and Ko, T.C.: Cell cycle and apoptosis regulation in GI cancers. In: Evers, B.M. (ed). Molecular Mechanisms of Gastrointestinal Cancers. Landes Bioscience: Austin, TX, 1999, pp.49-78.
  5. Ko, T.C., and Evers, B.M.: Molecular and cell biology. In: Townsend, C.M. Jr. (ed). Sabiston’s Textbook of Surgery. 16th Ed. WB Saunders Company: Philadelphia, PA, 2000, 13-27.
  6. Ko, T.C.: Colon and rectum. In: Townsend, C.M. Jr. (ed). Pocket Companion to Sabiston’s Textbook of Surgery. WB Saunders Company, Philadelphia, PA, 2002, 492-509.
  7. Ko, T.C., and Evers, B.M.: Molecular and cell biology. In: Townsend, C.M. Jr. (ed). Sabiston’s Textbook of Surgery. 17th Ed. WB Saunders Company: Philadelphia, PA, 2004, 27-44.

PRESENTATIONS

  1. Ko, T.C., Bertram, M.F., Prinz, R.A., Castelli, M., Marks, W., Djuricin, G., and Jacobs, H.K.: Effect of the cholecystokinin receptor antagonist L-364,718 on bile induced acute canine pancreatitis. University Surgical Residents’ Conference, Los Angeles, CA, February 10, 1990.
  2. Ko, T.C., Bertram, M.F., Prinz, R.A., Castelli, M., Djuricin, G., and Jacobs, H.K.: Effect of somatostatin analogue and cholecystokinin receptor antagonist on bile-induced acute canine pancreatitis. Midwest Surgical Association, Mackinac Island, MI, August 20, 1990.
  3. Prinz, R.A., Ko, T.C., Malt, S.B., Reynes, C.J., Marsan, R.E., and Freeark, R.J.: Common bile duct obstruction by fee floating tumor. International Surgical Week, Stockholm, Sweden, August 25, 1991.
  4. Chung, D.H., Evers, B.M., Townsend, C.M. Jr., Herndon, D.N., Ko, T.C., Uchida, T., and Thompson, J.C.: Cytokine regulation of gut ornithine decarboxylase gene expression and enzyme activity. Society of University Surgeons, Cincinnati, OH, February 13, 1992.
  5. Fedorak, I.J., Ko, T.C., Djuricin, G., McMahon, M., Thompson, K., and Prinz, R.A.: Secondary pancreatic infections: are they distinct clinical entities? Central Surgical Association, Madison, WS, March 7, 1992.
  6. Ko, T.C., Beauchamp, R.D., Ishizuka, J., Townsend, C.M. Jr., and Thompson, J.C.: Mechanism of action of transforming growth factor-beta on rat jejunal cells. Surgical Forum, New Orleans, LA, October 12, 1992.
  7. Beauchamp, R.D., Ko, T.C., Townsend, C.M. Jr., and Thompson, J.C.: Transforming growth factor-beta stimulates ornithine decarboxylase in murine fibroblasts. Surgical Forum, New Orleans, LA, October 13, 1992.
  8. Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Basic fibroblast growth factor-stimulated cell cycle progression in fibroblasts is mediated by ornithine decarboxylase activation. Association for Academic Surgery, Montreal, Quebec, Canada, November 20, 1992.
  9. Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Glutamine is essential for epidermal growth factor-stimulated intestinal cell growth. Society of University Surgeons, Seattle, WA, February 11, 1993.
  10. Ko, T.C., Ishizuka, J., Evers, B.M., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Mechanism of growth regulation of human pancreatic carcinoid cells. Society of Surgical Oncology 46th Cancer Symposium, Los Angeles, CA, March 21, 1993.
  11. Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Transforming growth factor beta inhibits rat intestinal cell growth by regulating cell cycle specific gene expression. Society for Surgery of the Alimentary Tract, Boston, MA, May 17, 1993.
  12. Henderson, A.M., Beauchamp, R.D., Ko, T.C., Townsend, C.M. Jr., and Thompson, J.C.: Lipopolysaccharide (LPS) induces AP-1 nuclear transcription factor in mouse liver. Surgical Forum, San Francisco, October 10, 1993.
  13. Upp, J.R. Jr., Ko, T.C., Townsend, C.M. Jr., Thompson, J.C., and Beauchamp, R.D.: Glutamine regulates cell cycle protein expression for intestinal cell growth. Surgical Forum, New Orleans, LA, October 24, 1995.
    Ko, T.C., Pan, F., Brown, D.B., Thompson, E.A., and Beauchamp, R.D.: Intracellular regulation of intestinal cell proliferation: a study using microinjection technology. Surgical Forum, New Orleans, LA, October 24, 1995.
  14. Ehrenfried, J.A., Ko, T.C., Thompson, E.A., and Evers, B.M.: Novel molecular mechanisms involved in hepatic regeneration. Association for Academic Surgery, Dearborn, MI, November 9, 1995.
  15. Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Optimal intestinal cell proliferation requires both glutamine and polyamine. Association for Academic Surgery, Dearborn, MI, November 9, 1995.
  16. Ehrenfried, J.A., Ko, T.C., Thompson, E.A., and Evers, B.M.: Novel molecular mechanisms involved in hepatic regeneration. Singleton Surgical Society, Galveston, TX, April 13, 1996.
  17. Matin, S., Ikeda, H., Ko, T.C., Guo, Y.-S., Wolf, S., Rajaraman, S., Herndon, D.N., and Thompson, J.C.: Gut mucosal apoptosis is increased rapidly after burn injury in rats. South Texas Chapter of the American College of Surgeons Committee on Trauma, Oklahoma City, OK, November 2, 1996.
  18. Iseki, H., Hellmich, M.R., Ko, T.C., and Townsend, C.M. Jr.: Human gastric cancer cells proliferate independent of exogenous growth factors through activation of Cdk2. Association for Academic Surgery, Chicago, IL, November 16, 1996.
  19. Iseki, H., Ko, T.C., Hellmich, M.R., and Townsend, C.M. Jr.: Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells. Society of University Surgeons, Tampa, FL, February 13, 1997.
  20. Iseki, H., Ko, T.C., Xue, X.Y., and Townsend, C.M. Jr.: A novel strategy for inhibiting growth of human pancreatic cancer cells by blocking cyclin-dependent kinase activity. Society for Surgery of the Alimentary Tract, Washington D.C., May 14, 1997.
  21. Ko, T.C., Seapan, A., Xue, X.Y., and Townsend, C.M. Jr.: Cyclin-dependent kinase 2 is required for G1/S transition in rat intestinal epithelial cells. Surgical Forum, Chicago, IL, October 14, 1997.
  22. Matin, S., Ikeda, H., Guo, Y.-S., Wolf, S.E., Ko, T.C., Rajaraman, S., Herndon, D.N., and Thompson, J.C.: Burn-induced stimulation of apoptosis-related genes in rat small bowel. Surgical Forum, Chicago, IL, October 14, 1997.
  23. Papaconstantinou, H.T., Hwang, K.O., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamine deprivation triggers apoptosis in intestinal epithelial cells. Society of University Surgeons, Milwaukee, WI, February 12, 1998.
  24. Litvak, D.A., Evers, B.M., Hellmich, M.R., Ko, T.C., Hwang, K.O., and Townsend, C.M. Jr.: Gut differentiation is associated with apoptosis and early induction of p21Waf1/Cip1. Society of University Surgeons, Milwaukee, WI, February 12, 1998.
  25. Papaconstantinou, H.T., Hwang, K.O., Helmet, M., Rajaraman, S., Townsend, C.M. Jr., and Ko, T.C.: Glutamine starvation induces apoptosis in cultured rat intestinal epithelial cells. American College of Surgeons, South Texas Chapter Annual Meeting, San Antonio, TX, February 20, 1998.
  26. Hwang, K.O., Papaconstantinou, H.T., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamine starvation promotes apoptosis in enterocytes. The National Student Research Forum, Galveston, TX, April 1998.
  27. Litvak, D.A., Papaconstantinou, H.T., Ko, T.C., and Townsend, C.M. Jr.: A novel cytotoxic agent for human carcinoid. American Association of Endocrine Surgeons, Orlando, FL, April 27, 1998.
  28. Ko, T.C., Xue, X.Y., Papaconstantinou, H.T., Hwang, K.O., and Townsend, C.M. Jr.: A novel synthetic inhibitor of human pancreatic cancer cells. Pancreas Club, New Orleans, LA, May 17, 1998.
  29. Ko, T.C., Pan, F., Brown, D.B., Thompson, E.A., and Beauchamp, R.D.: Cyclin D3 is essential for intestinal epithelial cell proliferation. Society for Surgery of the Alimentary Tract, New Orleans, LA, May 18, 1998.
  30. Ding, Q.-M., Ko, T.C., and Evers, B.M.: Differentiation of Caco-2 intestinal cells is associated with G1 arrest and suppression of cyclin-dependent kinase. American Gastroenterology Association, New Orleans, LA, May 20, 1998.
  31. Papaconstantinou, H.T., Boldogh, I., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamine deprivation decreases glutathione levels in intestinal epithelial cells. Surgical Forum, Orlando, FL, October 26, 1998.
  32. Papaconstantinou, H.T., Zhang, W., Ansari, N.H., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Caspases 2, 3 and 9 modulate methotrexate-induced apoptosis in intestinal epithelial cells. The National Student Research Forum, Galveston, TX, April 9, 1999.
  33. Papaconstantinou, H.T., Chung, D.H., Zhang, W., Ansari, N.H., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Caspase 2 and 3 modulate glutamine-starvation induced apoptosis in enterocytes. Society for Surgery of the Alimentary Tract, Orlando, FL, May 18, 1999.
    Oral Presentations (continued):
  34. Papaconstantinou, H.T., Zhang, W., Ansari, N.H., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Caspase 2, 3, and 9 modulate methotrexate-induced apoptosis in intestinal epithelial cells. Singleton Surgical Society, Galveston, TX, June 11, 1999.
  35. Papaconstantinou, H.T., Chung, D.H., Townsend, C.M. Jr., and Ko, T.C.: Glutamine-starvation induces mitochondrial damage independent of caspase activation in intestinal epithelial cells. Surgical Forum, San Francisco, CA, October 13, 1999.
  36. Ko, T.C.: Smad signaling in nontransformed gut epithelial cells. Symposium on Signal Transduction and Cancer, South Padre Island, TX, November 13, 1999.
  37. Papaconstantinou, H.T., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamine starvation-induced cell cycle arrest is associated with the induction of p21Cip1 and does not require caspase activation. Association for Academic Surgery, Philadelphia, PA, November 19, 1999.
  38. Cao, Y., Xie, C., Yu, W., Townsend, C.M. Jr., Thompson, E.A., and Ko, T.C.: Growth regulation of gut epithelial cells by TGF-beta. Association for Academic Surgery, Tampa, FL, November 4, 2000.
  39. Naoum, J.J., Mileski, W.J., Daller, J.A., Gomez, G.A., Gore, D.C., Kimbrough. T.D., Ko, T.C., Sanford, A.P., and Wolf, S.E.: Application of a clinical guideline which encourages the use of abdominal CT scan decreases the frequency of misdiagnosis in cases of suspected appendicitis. Southwestern Surgical Congress, Coronado, CA, April 8, 2002.
  40. Cao, Y., Liu, Y., Li, F., Song, D., Hellmich, M.R., Mileski, W.J., Townsend, C.M. Jr., and Ko, T.C.: New insights into colon carcinogenesis using molecular techniques. Texas Surgical Association, Austin, TX, September 28, 2002.
  41. Li, F., Cao, Y., Song, D., Townsend, C.M. Jr., and Ko, T.C.: TGF-beta/Smad signaling in colon cancer cells. Surgical Forum, San Francisco, CA, October 8, 2002.
  42. Cao, Y., Liu, Y., Li, F., Song, D., Hellmich, M.R., Mileski, W.J., Townsend, C.M. Jr., and Ko, T.C.: A novel mechanism of repression of TGF-beta signaling in human colon cancers. Association for Academic Surgery, Boston, MA, November 8, 2002.
  43. Slogoff, M.I., Li, F., Cao, Y., Guo, Y.-S., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Bombesin potentiates transforming growth factor-beta (TGF-beta)-mediated cell death in intestinal epithelial cells. Association for Academic Surgery, Boston, MA, November 9, 2002.
  44. Carter, Y.M., Haque, A., and Ko, T.C.: Primary adenocarcinoma of the appendix: single institutional experience from 1984-2002. American College of Surgeons, South Texas Chapter Annual Meeting, Houston, TX, March 7, 2003.
  45. Liu, Y., Cao, Y., Sambandam, K., Townsend, C.M. Jr., and Ko, T.C.: Identification of alternatively spliced forms of Evi-1 oncogene in human colorectal cancers. Society of Surgical Oncology 56th Annual Cancer Symposium, Los Angeles, CA, March 8, 2003.
  46. Bawduniak, J.J., Carter, Y.M., and Ko, T.C.: Parathyroid carcinoma: UTMB’s experience and review of the current literature. Singleton Surgical Society, Galveston, TX, June 6, 2003.
  47. Carter, Y.M., Haque, A., Shah, R.K., Walser, E.M., and Ko, T.C.: Primary adenocarcinoma of the appendix: UTMB’s experience from 1984-2003. Singleton Surgical Society, Galveston, TX, June 6, 2003.
  48. Cao, Y., Chen, L., Townsend, C.M. Jr., Thompson, E.A., and Ko, T.C.: Identification of apoptotic genes mediating transforming growth factor-beta/Smad3-induced cell death in intestinal epithelial cells using genomic approach. Surgical Forum, Chicago, IL, October 20, 2003.
  49. Cao, Y., Townsend, C.M. Jr., and Ko, T.C.: Transforming growth factor-beta (TGF-beta) induces vascular endothelial growth factor (VEGF) and plasminogen activator inhibitor-1 (PAI-1) gene expression through Smad3 transcription factor. Surgical Forum, San Francisco, CA, October 19, 2005.
  50. Nguyen, K.A., Cao, Y., Chen, J.R., Townsend, C.M. Jr., and Ko, T.C.: Dietary fiber enhances a tumor suppressor signaling pathway in the gut. Southern Surgical Association, Hot Springs, VA, December 5, 2005.
  51. Cao, Y., Deng, C., Townsend, C.M. Jr., and Ko, T.C.: TGF-beta inhibits AKT-induced transformation in intestinal epithelial cells. Society of University Surgeons, San Diego, CA, February 9, 2006.
    Poster Presentations:
  52. Ko, T.C., Prinz, R.A., Castelli, M., Marks, W., Djuricin, G., Jacobs, H.K., and LaBarbara. M.: Effect of SMS 201-995 on bile induced acute canine pancreatitis. American Pancreatic Association, Chicago, IL, November 2, 1989.
  53. Ko, T.C., Bertram, M.F., Prinz, R.A., Castelli, M., Marks, W., Djuricin, G., and Jacobs, H.K.: Effects of the cholecystokinin receptor antagonist L-364,718 on bile induced acute canine pancreatitis. Pancreas Club, San Antonio, TX, May 14, 1990.
  54. Ko, T.C., Flisak, M., and Prinz, R.A.: Superselective intraarterial methylene blue injection-a novel method of localizing gastrinoma. Pancreas Club, New Orleans, LA May 19, 1991.
  55. Fedorak, I.J., Ko, T.C., Thompson, K., and Prinz, R.A.: Are the varieties of pancreatic infection distinct clinical entities? Pancreas Club, New Orleans, LA, May 19, 1991.
  56. Ko, T.C., Evers, B.M., Chung, D.H., Townsend, C.M. Jr., Carraway, R.E., Uchida, T., and Thompson, J.C.: Xenopsin stimulates small intestinal growth in rats. American Gastroenterology Association, San Francisco, CA, May 10, 1992.
    Poster Presentations (continued):
  57. Ko, T.C., Beauchamp, R.D., Ishizuka, J., Townsend, C.M. Jr., and Thompson, J.C.: Transforming growth factor beta uncouples ornithine decarboxylase activation from DNA synthesis in rat jejunal cells. 9th International Symposium on Gastrointestinal Hormones, Leuven, September 1, 1992.
  58. Ko, T.C., Ishizuka, J., Cerdas, K., Evers, B.M., Beauchamp, R.D., Townsend, C.M. Jr., and Thompson, J.C.: Ornithine decarboxylase activity is essential for growth of human pancreatic carcinoid cells. International Symposium on Polyamines in Cancer, Montgomery, TX, November 8, 1992.
  59. Zhang, T., Beauchamp, R.D., Ko, T.C., Sheng, H.M., Gomez, G., Townsend, C.M. Jr., Thompson, J.C., and Greeley, G.H. Jr.: Phorbol ester-induced growth inhibition and immediate-early gene expression in a human pancreatic carcinoid cell line. American Gastroenterology Association, Boston, MA, May 19, 1993.
  60. Ko, T.C., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor beta inhibits cyclin D1 induction during G1 phase of the cell cycle. American Association for Cancer Research, San Francisco, CA, April 12, 1994.
  61. Ko, T.C., Beauchamp, R.D., and Thompson, E.A.: Cyclin D1 antisense oligonucleotide inhibits intestinal epithelial cell proliferation. American Gastroenterology Association, New Orleans, LA, May 18, 1994.
  62. Ko, T.C., Sheng, H.M., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor-beta1 inhibits transcription of cyclin D1 in intestinal epithelial cells. American Gastroenterology Association, New Orleans, LA, May 18, 1994.
  63. Ko, T.C., and Beauchamp, R.D.: Growth factor regulation of immediate early gene expression in rat intestinal epithelial cells. American Gastroenterology Association, Peptide Growth Factors in The GI Tract, Vail, CO, June 26, 1994.
  64. Ko, T.C., Sheng, H.M., Reisman, D., Thompson, E.A., and Beauchamp, R.D.: Cyclin D regulation in intestinal epithelial cells. American Association for Cancer Research special conference “Transcriptional control of cell growth and differentiation,” Chatham, MA, October 17, 1994.
  65. Ko, T.C., Sheng, H.M., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor-beta1 regulation of cyclin D1 in intestinal epithelial cells. American Association for Cancer Research, Toronto, Ontario, Canada, March 19, 1995.
  66. Ko, T.C., Sheng, H.M., Sheng, G.G., Thompson, E.A., and Beauchamp, R.D.: Effect of fasting and refeeding on cyclin D3 and Cdk4 expression in rat jejunum. American Gastroenterology Association, San Diego, CA, May 15, 1995.
  67. Fan, R.S., Li, W., Ko, T.C., and Brattain, M.G.: Role of autocrine TGF-beta in regulating G1 cell cycle components. Keystone Symposia on the Cell Cycle, Taos, NM, January 12, 1996.
  68. Ko, T.C., Sheng, H.M., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor beta regulation of Cdk4 and Cdk2 kinase activity during G1 progression in intestinal epithelial cells. Keystone Symposia on the Cell Cycle, Taos, NM, January 13, 1996.
  69. Ko, T.C., Sheng, H.M., Thompson, E.A., and Beauchamp, R.D.: Transforming growth factor-beta1 inhibits G1 cyclin-dependent kinase activities in intestinal epithelial cells. American Association for Cancer Research, Washington D.C., April 22, 1996.
  70. Zhang, T., Nanney, L., Ko, T.C., Luongo, C., Lamps, L., DuBois, R.N., and Beauchamp, R.D.: Overexpression of cyclin D1 in intestinal polyposis of Min mice and human familial adenomatous polyposis subjects. American Association for Cancer Research, Washington D.C., April 22, 1996.
  71. Ko, T.C., Thompson, J.C., and Thompson, E.A.: Effect of starvation and glutamine on intestinal epithelial cell cycle and Cdk2 activity. American Gastroenterology Association, San Francisco, CA, May 21, 1996.
  72. Iseki, H., Ko, T.C., Guo, Y.-S., and Townsend, C.M. Jr.: Olomoucine blocks IGF-I-stimulated proliferation and cyclin-dependent kinase activity of human gastric cancer cells. American Association for Cancer Research, San Diego, CA, April 15, 1997.
  73. Fan, R.S., Ko, T.C., and Brattain, M.G.: Alteration in control of cell cycle transit associated with growth factor independence. American Association for Cancer Research, San Diego, CA, April 15, 1997.
  74. Gong, J.G., Ko, T.C., and Brattain, M.G.: Stimulation of p21/WAF1 expression by TGF-ß1 in G1 is required for inhibition of cyclin A/CDK2 kinase activity and cell cycle transit. American Association for Cancer Research, San Diego, CA, April 15, 1997.
  75. Fan, R.S., Ko, T.C., and Brattain, M.G.: Lack of cyclin A kinase activity associated with incomplete pRb phosphorylation and absence of cell cycle progression. American Association for Cancer Research, New Orleans, LA, March 30, 1998.
  76. Sergina, N.V., Fan, R., Ko, T.C., and Brattain, M.G.: Maximal activation of cyclin-dependent kinase 2 by insulin during cell cycle re-entry requires autocrine TGF-beta. Keystone Symposia on the Cell Cycle, Keystone, CO, March 28, 1998.
  77. Ko, T.C., Xue, X.Y., Hwang, K.O., and Townsend, C.M. Jr.: Roscovitine blocks cell cycle progression and induces apoptosis in human pancreatic cancer cells. Keystone Symposia on the Cell Cycle, Keystone, CO, March 31, 1998.
  78. Papaconstantinou, H.T., Powell, S.J., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Glutamate and asparagine protect against the induction of apoptosis in glutamine-deprived intestinal epithelial cells. American Gastroenterology Association, New Orleans, LA, May 18, 1998.
  79. Papaconstantinou, H.T., Zhang, W., Ansari, N.H., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Caspase 3 and 2 modulate methotrexate-induced apoptosis in intestinal epithelial cells. American Society for Cell Biology, San Francisco, CA, December 1998.
  80. Schuler, H.J., Cao, Y., and Ko, T.C.: The role of caspase 3 in TGF-b mediated apoptosis in gut epithelial cells. 2001 Summer Undergraduate Research Program, Galveston, TX, August 9, 2001.
  81. Cao, Y., Li, F., Song, D., Townsend, C.M. Jr., and Ko, T.C.: TGF-beta/Smad signaling in colon cancer cell MC-26. 6th Life Science Symposium, Galveston, TX, May 8, 2002.
  82. Slogoff, M.I., Li, F., Cao, Y., Guo, Y.-S., Hellmich, M.R., Townsend, C.M. Jr., and Ko, T.C.: Bombesin potentiates transforming growth factor-beta (TGF-beta)-mediated cell death in intestinal epithelial cells. 6th Life Science Symposium, Galveston, TX, May 8, 2002.
  83. Cao, Y., Yu, W., Xie, C., Xue, X.Y., Choy, L., Townsend, C.M. Jr., Thompson, E.A., and Ko, T.C.: Critical Role of Smad3 in TGF-beta-Mediated Apoptosis and Growth Inhibition in Epithelial Cells. American Society for Cell Biology, San Francisco, CA, December 15, 2002.
  84. Li, F., Cao, Y., Townsend, C.M. Jr., and Ko, T.C.: p38 MAPK signaling pathway is involved in transforming growth factor-beta (TGF-beta)/Smad3-induced apoptosis. American Gastroenterology Association, Orlando, FL, May 20, 2003.
  85. Wang, J.J., Sergina, N., Ko, T.C., Gong, J., Wang, X.F., and Brattain, M.G.: Autocrine negative TGFbeta controls cell cycle inhibition through a p21 mediated mechanism. American Association for Cancer Research, Orlando, FL, March 28, 2004.
  86. Cao, Y., Li, F., Hellmich, M.R., Guo, Y.-S., Sheng, H.M., Townsend, C.M. Jr., and Ko, T.C.: Transforming growth factor-beta and bombesin synergistically activate cyclooxygenase-2. American Association for Cancer Research, Orlando, FL, March 30, 2004.
  87. Cao, Y., Liu, Y., Chen, L., Thompson, E.A., Townsend, C.M. Jr., and Ko, T.C.: Inhibitor of differentiation (Id)-2 is a downstream target gene of transforming growth factor (TGF)-beta in the regulation of apoptosis. American Gastroenterology Association, New Orleans, LA, May 16, 2004.
  88. Nguyen, N.A., Cao, Y., and Ko, T.C.: N-terminal domain of smad3 plays an important role in TGF-beta-induced apoptosis of gut epithelial cells. 13th Annual Science Forum, Galveston, TX, April 8, 2005.
  89. Cao, Y., Liu, Y., Chen, L., Thompson, E.A., Townsend, C.M. Jr., and Ko, T.C.: Inhibitor of differentiation (Id)-2 is a downstream target gene of transforming growth factor (TGF)-beta in the regulation of intestinal epithelial cell apoptosis. 13th Annual Science Forum, Galveston, TX, April 8, 2005.
  90. Cao, Y., Deng, C., and Ko, T.C.: TGF-beta regulates multiple transcription factors through repression of Id2 for induction of apoptosis in gut epithelial cells. American Gastroenterology Association, Chicago, IL, May 18, 2005.
    Poster Presentations (continued):
  91. Nguyen, K.A., Cao, Y., and Ko, T.C.: N-terminal domain of Smad3 plays an important role in TGF-beta-induced apoptosis of gut epithelial cells. American Gastroenterology Association, Chicago, IL, May 18, 2005.
  92. Zhang, W., Cao, Y., Falzon, M., and Ko, T.C.: PTHrP is an essential mediator of TGF-beta-induced apoptosis in human liver cells. 14th Annual Science Forum, Galveston, TX, June 7, 2006.
  93. Zhang, G.-H., Cao, Y., Zhang, W., and Ko, T.C.: Dietary fiber enhances TGF-beta signaling pathway in the mouse gut. 10th Life Science Symposium, Galveston, TX, May 25, 2007.
  94. Zhang, W., Cao, Y., Falzon, M., Townsend, C.M. Jr., and Ko, T.C.: Smad3 mediates TGF-beta-induced PTHrP expression in human hepatocellular carcinoma cells. 10th Life Science Symposium, Galveston, TX, May 25, 2007.
  95. Liu, X.H., Cao, Y., Zhao, J., Li, F., Hellmich, M.R., Guo, Y.-S., Sheng, H., Townsend, C.M. Jr., and Ko, T.C.: The role of p38MAPK in the cross-talk between TGF-beta receptors and GRP-R. 10th Life Science Symposium, Galveston, TX, May 25, 2007.
  96. Cao, Y., Zhang, W., Liu, X.H., Zhang, G.-H., Townsend, C.M. Jr., and Ko, T.C.: A novel mediator of TGF-beta-induced apoptosis. 10th Life Science Symposium, Galveston, TX, May 25, 2007.
INVITED LECTURES
  1. Regulation of intestinal epithelial cell renewal by TGF-beta. Gastrointestinal Research Seminar Series, the University of Texas Medical Branch, Galveston, TX, January 4, 1995.
  2. Molecular regulation of intestinal cell proliferation. Wisconsin Surgical Society, Galveston, TX, May 3, 1995.
  3. Regulation of intestinal epithelial cell proliferation by transforming growth factor beta. Departmental Grand Rounds Research Seminar, the University of Texas Medical Branch, Galveston, TX, June 7, 1995.
  4. Effects of starvation and glutamine on intestinal cell proliferation. Departmental Grand Rounds Research Seminar, the University of Texas Medical Branch, Galveston, TX, June 5, 1996.
  5. Thyroid cancers. Departmental Grand Rounds, the University of Texas Medical Branch, Galveston, TX, February 26, 1997.
  6. Cell cycle and apoptosis in pancreatic cancer cells. 1997 Surgery Symposium of the University of Texas Health Science Center, San Antonio, TX, October 2, 1997.
  7. Cdk inhibition leads to apoptosis in pancreatic cancer cells. Hormone Action Laboratories Meeting, the University of Texas Medical Branch, Galveston, TX, December 15, 1997.
  8. Novel therapy in pancreatic cancer. Department of Surgery Research Symposium, the University of Texas Medical Branch, Galveston, TX, May 11, 1998.
  9. Evi-1 suppression of smad signaling. Hormone Action Laboratories Meeting, the University of Texas Medical Branch, Galveston, TX, May 24, 1999.
  10. TGF-beta signaling pathway – from receptor to the nucleus. “The Molecular Surgeon” symposium, Baylor College of Medicine, Houston, TX, August 21, 1999.
  11. TGF-beta signaling in the gut. Surgical Biology Club I, San Francisco, CA, October 10, 1999.
  12. Evi-1 interaction with CBP. Hormone Action Laboratories Meeting, the University of Texas Medical Branch, Galveston, TX, April 17, 2000.
  13. Regulation of epithelial cell growth by TGF-beta. Gulf Coast GI Research Forum, League City, TX, June 3, 2000.
  14. The mechanism of TGF-beta suppression by Evi-1 oncogene. Endocrine Seminar, the University of Texas Medical Branch, Galveston, TX, October 23, 2001.
  15. Sealy Center for Cancer Cell Biology Research in Progress, the University of Texas Medical Branch, Galveston, TX, February 27, 2002.
  16. Presidential Address: Excellence in academic surgery. Association for Academic Surgery, Boston, MA, November 9, 2002.
  17. A novel mechanism that inactivates tumor suppressor pathway in human colorectal cancer. Department of Surgery Research Symposium, the University of Texas Medical Branch, Galveston, TX, January 15, 2003.
  18. Career choice in general surgery. Departmental Grand Rounds, the University of Texas Medical Branch, Galveston, TX, January 29, 2003.
  19. Transforming growth factor-beta and human diseases. Departmental Grand Rounds, Baylor College of Medicine, Houston, TX, December 1, 2004.
  20. Colorectal cancer. Hematology-Oncology Grand Rounds, the University of Texas Medical Branch, Galveston, TX, October 12, 2005.
  21. Regulation of the TGF-beta tumor suppressor pathway. Research in Progress Seminar Series, the University of Texas Medical Branch, Galveston, TX, November 28, 2006.
    Visiting Professorships:
  22. Current topics in TGF-beta and Smads. Yamagata University, Yamagata, Japan October 18, 1999.
  23. Regulation of TGF-beta/Smad3 signaling. The Feist-Weiller Cancer Center Fall Seminar, Louisiana State University Health Sciences Center, Shreveport, LA, November 10, 2003.
  24. Transforming growth factor-beta and human diseases. Departmental Grand Rounds, Louisiana State University Health Sciences Center, Shreveport, LA, November 11, 2003.

Contact Information

Tien C. Ko, MD
  • Tien C. Ko, MD

  • Professor of Surgery Vice Chairman for Harris County Hospital District Chief of Surgery at Lyndon B. Johnson General Hospital

  • Department of Surgery

  • The University of Texas Medical School at Houston
    5656 Kelley 30S62008
    Houston, Texas 77026

  • phone: (713) 566-5765
    fax: (713) 566-4583
    e-mail: Tien.C.Ko@uth.tmc.edu

Executive Assistant:
Carolyn Lewis