The Department of Surgery at the University of Texas Medical School at Houston
Department of Surgery
MHH LifeFlight

Faculty Biography

Department of Surgery,
Division of Acute Care Surgery,
Trauma and Critical Care


Rosemary Kozar, M.D., Ph.D.

James H. "Red" Duke, Jr. Professor of Surgery and
Chief of Trauma, Memorial Hermann Hospital - TMC

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Rosemary Kozar MD, PhD is the James H. "Red" Duke, Jr. Professor of Surgery and Chief of Trauma, Memorial Hermann Hospital–TMC. She received her medical degree from Temple University, Philadelphia, PA and a PhD in Molecular Physiology and Biophysics at Baylor College of Medicine, Houston, TX. She began her residency at The University of Texas Medical School at Houston and finished at Temple University and also completed a fellowship in Surgical Critical Care. Dr. Kozar is a former Chair of the Education Committee of the AAS and Chair of the Education Committee of the SUS. She is currently the Vice President of the Association of Women Surgeons. Her research interests are the impact of enteral nutrients on the post-ischemic gut for which she is NIH funded. She has also published numerous articles in the area of trauma and critical care.

 

EDUCATION

Undergraduate Education

1976-1980 B.S., Rehabilitation, Indiana University of PA, Indiana, PA
1980-1982 Post-baccalaureate, Pre-med, University of Pittsburgh, Pittsburgh, PA

Graduate Education

1982-1986 M.D., Temple University School of Medicine. Philadelphia, PA
1988-1992 Ph.D., Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas

Postgraduate Training

1986-1988 Surgery Resident, The University of Texas Medical School at Houston
1992-1995 Surgery Resident, Temple University School of Medicine, Philadelphia, PA
1999-2000 Surgical Critical Care Fellowship, The University of Texas Medical School at Houston

ACADEMIC APPOINTMENTS

1988-1992 Research Associate, Department of Medicine,
Baylor College of Medicine, Houston, TX
1995-1996 Instructor of Surgery, MCP Hahnemann University
Philadelphia, PA, Chairman, Joel Roslyn
1996-1999 Assistant Professor of Surgery, MCP Hahnemann University, Philadelphia, PA
Jan. - May 1999 Interim Director of Trauma and Critical Care
Hahnemann University Hospital
Philadelphia, PA
1999- 2003 Assistant Professor of Surgery
The University of Texas Medical School at Houston
Aug. 2001- present Regular Faculty Member of the Graduate School of Biomedical Sciences
The University of Texas Medical School at Houston
2003 – 2007 Associate Professor of Surgery, The University of Texas Medical School at Houston
2007 –present Professor of Surgery, The University of Texas Medical School at Houston

HOSPITAL APPOINTMENTS

1995-1999 Hahnemann University Hospital
Broad and Vine
Philadelphia, PA 19102
1995-1999 Medical College of Pennsylvania
3300 Henry Avenue
Philadelphia, PA 19129
1999 - present Memorial Hermann Hospital - TMC
6411 Fannin
Houston, TX 77030
1999-2003 Lyndon B. Johnson General Hospital
Harris County Hospital District
Houston, TX 77030

LICENSURE

1990 Medical Physician and Surgeon, Commonwealth of PA
1999 Texas

BOARD CERTIFICATION

1996 American Board of Surgeons, Diplomate
2000 Certificate of Added Qualifications in Surgical Critical Care

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PROFESSONAL ORGANIZATIONS

National

1990 Initiate, American College of Surgeons
1991 Association of Academic Surgeons
1995 Association of Women Surgeons
1998 Fellow, American College of Surgeons
1998 Society of Critical Care Medicine
1999 American Society of Parenteral and Enteral Nutrition
2000 Shock Society
2002 Society of University Surgeons
2004 Western Trauma Association
2004 American Association for the Surgery of Trauma

COMMITTEES/POSITIONS

2002 Councilor for the Association of Women Surgeons
2002 Education Committee, Association of Academic Surgeons
2003 Education Committee, Society of University Surgeons
2003 Chair of Education Committee, Association of Academic Surgeons
2003 Editorial Board American Journal of Surgery
2003 Chair of Membership Committee, Association of Women Surgeons
2004 Western Trauma Association
2004 American Association for the Surgery of Trauma

HONORS AND AWARDS

2004 Alpha Omega Alpha Student Research Fellowship.
Research mentor for recipient Keith Gates
Medical student at The University of Texas Medical School at Houston
2003-2004 Dean’s Teaching Excellence Award
The University of Texas Medical School at Houston
2002-2003 Dean’s Teaching Excellence Award
The University of Texas Medical School at Houston
2002 Career Development Award (K08). NIH. Gut Ischemia/Reperfusion Injury is Modulated by Enteral Nutrients.
2002 C. Frank Webber Prize for Student Research, Third Place, University of Texas Medical School at Houston, Research Mentor for Craig Messick, medical student.
1998 Mary Dewitt Petit Research Fellowship. Medical College of Pennsylvania Alumnae/i Association, Philadelphia, PA
1994 Delaware Valley Vascular Society Residents Competition,
First Prize, Philadelphia, PA
1990 Career Development Award (NRSA). NIH. Free radical-induced alterations in endothelial cell function.
1986 The Doctor Herman Brown Award for Excellence in the Study of the Art and Science of Surgery, Temple University School of Medicine, Philadelphia, PA
1985 Boehringer Ingelheim National Pharmacology Award, First Prize, Temple University School of Medicine, Philadelphia, PA

SERVICE ON COMMITTEES:

UT MEDICAL SCHOOL - HOUSTON COMMITTEES:

Animal Welfare Committee
Educational Advisory Committee, Department of Surgery
Director, Surgical Resident’s Basic Science Course
Faculty Interviewer for Prospective Medical Students
Invited speaker at the Freshman Medical Student Retreat, “Marriage and Medicine” August 2002.
Master Advisor for 1st year Medical Students 2002- present
Judge for 2002, 2003, 2004 Medical Student Research Forum at the University of Texas Medical School at Houston
Speaker, Student Surgical Association and AMWA

GRADUATE SCHOOL COMMITTEES:

Thesis Committee for MD, PhD Student
Judge, 2004 Graduate Student Research Forum
MD/ PhD Committee 2004 - present

HOUSTON COMMUNITY:

Instructor for Advanced Trauma Life Support since 1986
Volunteer Physician, Casa Maria Medical Clinic, Houston, Texas 1988-1992
First Aide Instructor for Cub Scouts, Houston, TX, November 2000
Invited Speaker: “Women Are Surgeons”
Spring Woods Senior High School, Spring Branch School District, Houston, TX, April 2001
High Tower High School, Fort Bend School District, Houston, TX, May 2001

Science Fair Judge, T.H. Rogers Middle School, 2002
Featured on “Women Docs” Lifetime Channel, January 20, 2002.
Invited Speaker: “Women in Medicine”
AMWA: Baylor College of Medicine, Houston, TX, 2002
and The University of Texas Medical School at Houston , 2003
Invited Speaker: “Women in Medicine and Science” Pershing Middle School Girls Math and Science Club, 2004

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RESEARCH MENTOR:

Andrew Kline; Medical student; summer 1998
James Cipolla; Surgical Resident; 1998-1999
Lynelle Thorpe; Undergraduate student; summer 2001
Craig Messick; Medical student; summer 2002
Holland Patterson; Medical student; summer 2002
Keith Gates; Medical student; summer 2002
Marshall Smith; Medical student; summer 2003
Justin Weatherall; Medical student; summer 2003
Elizabeth Verner-Cole; Medical student; summer 2003
Michael Adam Childs; Medical student; summer 2004

GRANT SUPPORT

CURRENT

P50 Impaired Gut Transit and Hypertonic Saline. Co-investigator. 10% effort. NIH. $1,372,602. July 2004 to June 2009.
KO8 GM62975. Gut Ischemia/Reperfusion Injury is Modulated by Enteral Nutrients. Principal Investigator 75% effort. NIH. $596,430 8-2002 to 7-2007.
NIGMS T-32 Training Grant T32-GM08792. Role of the gut in postinjury multiple organ failure. Mentor. NIH $1,278,732 7-2001 to 6/2006.

PAST

NRSA HL08363-02. Free radical-induced alterations in endothelial cell function. Principal Investigator.1990-1992. $46,000.
XOMA $300,000: Multicenter Phase III Trial to assess the safety and efficacy of Bactericidal/Permeability-Increasing Protein in patients with hemorrhage due to trauma.
3/98-6/99.
Mary DeWitt Petit Research Fellowship. Antioxidant defense during recovery from acute lung injury. Principal Investigator. 7/98-6/99. $10,000.
US Surgical. Laparoscopic Repair of Traumatic Diaphragmatic Injuries. Principal Investigator. 7/98-6-99. $21,000.

PUBLICATIONS

PUBLISHED ABSTRACTS
  1. Kozar RA, Abedin ZR, Abedin MZ, Trooskin SZ. Expression of epidermal growth factor in Type II Pneumocytes: A potential mechanism for recovery from acute lung injury. Investigative Medicine 1998; 463 (3):223A.
  2. Kozar RA, Schultz SG, Weisbrodt N, DeSoignie R, Hassoun HT, Moore FA.
    Intraluminal nutrients enhance gut ischemia/reperfusion injury. Shock 2000; 13 supp;28
  3. Kozar RA, Kaplan LJ, Cipolla J, Meija J, Haber M. Laparoscopic repair of traumatic diaphragmatic injuries. J Surg Res 2000; 91(2):358-359.
  4. Hassoun HT, Weisbrodt NW, Kozar RA, Mercer DW, Moody FG, Moore FA. Inducible nitric oxide synthase mediates impaired small intestinal transit after severe gut ischemia/reperfusion. J Surg Res 2000; 91 (2): 353.
  5. Kozar RA, Hu S, Schultz SG, Hassoun HT, Moore FA. Specific enteral nutrients alter
    mucosal blood flow during gut ischemia/reperfusion. JPEN 2001; 25 (1):S11.
  6. Von Maszewski M, Cocanour CS, McKinley B, Kozar RA, DeSoignie R, Weisbrodt N,
    Moore FA. MMC’s exist after trauma and predict enteral tolerance. J Trauma 2001; 50 (1):178.
  7. Kozar RA, Schultz SG, Hassoun HT, DeSoignie R, Moore FA. Intraluminal nutrients alter gut permeability following gut ischemia/reperfusion. Shock 2001; 15 supp:65.
  8. Kozar RA, Moore EE, Kudsk K, Jurkovich G, Moore FA. Enteral tolerance following severe trauma is reliably achieved by a standardized protocol. J Surg Res. 2001; 100 (2):292-293.
  9. Holcomb JB, McMullin NR, Kozar RA, Lygas MH, Macaitis JM, Moore FA. Morbidity from rib fractures increases after age 45. J Trauma. 2002; 52 (1):200.
  10. McKinley BA, Cocanour CS, Kozar RA, Ware DN, Sailors RM, Marquez A, Moore FA. Normal vs supranormal O2 delivery goals in shock resuscitation: the response is the same. J Trauma 2002; 53(1): 825-832.
  11. Balogh Z, McKinley BA, Holcomb JB, Miller CC, Cocanour CS, Kozar RA, Moore FA. Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of bad outcome. J Trauma. 2002;53(1):198.
  12. Attuwaybi BO, Hassoun H, Kozar RA, Moore FA. Hypothermia protects against gut ischemia-reperfusion (I/R) induced impaired intestinal transit by inducing impaired intestinal transit by inducing heme oxygenase-1 (HO-1). J Surg Res. 2002; 107 (81): 294.
  13. Kozar RA, Holcomb JB, Macatis J, DeSoignie R, Moore FA. Superior mesenteric artery occlusion (SMAO) models shock-induced gut Ischemia/reperfuison. J Surg Res. 2002;107 (P55): 321.
  14. Kozar RA, Lucci A, Azzizadeh A, Miller CC, Cocanour CS, Potts J, Fischer C, Brundage SI. A brief intervention by surgeons can influence medical students towards a career in surgery. J Surg Res. 2002; 107 (4): 268.
  15. Domonoske B, Cocanour C, Valdivia A, Kozar, RA, Pousman R, Moore F.
    Aggressive Glucose Control: Implementation in an ICU. Critical Care Medicine. 2003;
    451: A108.
  16. Suliburk JW, Ware DN, Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Moore FA. Vacuum assisted wound closure (VAWC) allows for early abdominal fascial closure in severely injured trauma patients requiring aggressive resuscitation. J Trauma. 2003;54(1):207.
  17. Cocanour CS, Dial ED, Kozar RA, Lichtenberger LM, Messick C, Moore FA. Gastric Alkalinization following major trauma. J Trauma.2003;54(1):211.
  18. Cocanour CS, Weisbrodt N, Kozar RA, Messick C, Moore FA. Gastric emptying following traumatic shock. Shock 2003; 19:18.
  19. Marr AB, McKinley BA, Sailors RM, Valdivia A, Kozar RA, Cocanour CS, Moore FA. Starling curve generation during shock resuscitation: Can it be done? Shock 2003; 19:78
  20. Attuwaybi BO, Kozar RA, Moore-Olufemi S, Gates K, Hassoun HT, Moore FA. Hypertonic saline induces HO-1 expression and abrogates gut inflammation and dysfunction following shock-induced gut ischemia/reperfusion. Shock 2003; 19:194.
  21. Moore-Olufemia S, Kozar RA, DeSoignie R, Attuwaybi B, Gates K, Moore FA. Hypertonic saline enhances mucosal blood flow and lessens mucosal injury following gut ischemia/reperfusion. Shock 2003; 19: 200.
  22. Kozar RA, Schultz SG, Bick R, DeSoignie R, Moore FA. Metabolizable solutes maintain integrity of the actin cytoskeleton and membrane barrier function following mesenteric ischemia/reperfusion. Shock 2003; (19):217.
  23. Attuwaybi B, Kozar RA, Sato N, Moore-Olufemia S, Weisbrodt NW, Moore FA. Hypertonic saline prevents inflammation and impaired intestinal transit after gut ischemia/reperfusion by inducing heme oxgenase 1(H0-1) enzyme. J Trauma 2003; 55(1): 205.
  24. Sato N, Kozar RA, Zou L, Moore-Olufemi S, Weisbrodt NW, Moore FA. Cyclooxygenase-2 (COX-2) plays a role in mediating impaired internal transit after gut ischemia/reperfusion (I/R). J Surg Res. 2003; 114 (2):287.
  25. Attuwaybi B, Kozar RA, Moore-Olufemi S, Sato N, Weisbrodt N, Hassoun H, Moore FA.
    Heme-oxygenase-1 (HO-1) induction by hemin protects against gut ischemia/reperfusion injury. J Surg Res. 2003; 114 (2):289.
  26. Kozar RA, Anderson K, Chaves-Escobar S, Theil M, Brundage S. Preclinical students Who are surgeons? J Surg Res. 2003; 114 (2):259.
  27. Moore FA, Hassoun HT, Kozar RA, Weisbrodt NW. Shock Induced Ileus: Issues and consequences. Shock 2004; 21:82.
  28. Kozar RA, Schultz SG, Verner-Cole E, Bick R, DeSoignie R, Poindexter B, Moore FA. Enternal arginine, an immune enhancing agent, impair gut barrier function following mesenteric ischemia/reperfusion. J Trauma. 2004; 56 (2):463.
  29. McKinley B, Gonzalez E, Balldin B, Majid T, Valdivia A Cocanour CS, Kozar RA.
    Revisiting the “Bloody Vicious Cycle”. Shock. 2004; 21:137.
  30. Gonzalez E, Kozar RA, Suliburk J, Mercer D, Moore FA. Presence of D-Lactate increases
    ileal mucosal injury after mesenteric ischemia/reperfusion. Shock. 2004; 21:172.
  31. Moore-Olufemi, Kozar RA, Moore FA, Hassoun HT, Sato N, Cox CS, Kone BC.
    Iscehmic preconditioning protects against intestinal ischemia/reperfusion injury. Shock. 2004; 21: 179.
  32. Gonzalez EA, Kozar RA, Sulibruk JW, Moore FA, Mercer DW. The isomeric composition of Lactated Ringer’s has no differential effect of gstric dysfunction after mesenteric ischemia/reperfusion. J Surg Res. 2004;121:334.
  33. Kozar RA, Moore JB, Miles SE, Holcomb JH, Moore EE, Cothern C, Moore FA. Complications of nonoperative management of high grade blunt hepatic injuries. J Trauma 2005;58(1):222.
  34. Gonzalez EA, Kozar RA, Sulibruk JW, Tweardy DJ, Mercer DW, Moore FA. Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosis via cytochrome C pathway. J Trauma 2005;58(1): 215.

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REFEREED ARTICLES
  1. Kozar RA, Pitale M, White JV, McGowen J, Cundy K, Comerota A. Mechanism of direct antibiotic protection of Dacron vascular grafts. Current Surgery 1987; 44(3):214-216.
  2. White JV, Freda J, Kozar RA, Serfass D, Cundy K, Comerota AJ, Ritchie WP. Does bacteremia pose a direct threat to synthetic vascular grafts? Surgery 1987; 102(2):402-408.
  3. Kozar RA, McKeone BJ, Pownall HJ. Mechanism of cellular phospholipid efflux. J Surg Res. 1993; 55:548-52.
  4. Kozar RA, McKeone BJ, Pownall HJ. Free radical-induced alterations in endothelial cell
    function. J Surg Res. 1994;56:32-36.
  5. Karam JA, Kozar RA. Solitary rupture of an accessory spleen. J Trauma. 1998; 44(1):220-221.
  6. Klein AJP, Kozar RA, Kaplan LJ. Traumatic hematuria and polycystic kidney disease.
    The American Surgeon. 1999; 65 (5):464-466.
  7. Kozar RA, Weibel CJ, Abedin MZ, Cipolla J, Klein D, Haber M, Trooskin SZ. Antioxidant enzyme induction during recovery from acute lung injury. Crit Care Med. 2000; 28 (7):2486-2491.
  8. Nunes LW, Simmins S, Kozar RA, Kinback R, Hallowell MJ, Mulhern C. Feasibility and
    profitability of a radiology department’s providing a trauma ultrasound examination for abdominal/pelvic free fluid as part of a trauma alert team. Academic Radiology. 2001; (1):88-95.
  9. Nunes LW, Simmons S, Hallowell MJ, Kinback R, Trooskin S, Kozar R. Diagnostic
    performance of trauma ultrasound in identifying abdominal/pelvic free fluid and diagnostic
    performance of ultrasonographic free fluid in identifying significant abdominal/pelvic
    injury. Academic Radiology. 2001; 8(2):128-136.
  10. Fuchs BD, Smull G, Chang B, McMaster J, Getsy J, Kozar RA. Under-appreciation of sleep disorders as a cause of motor vehicle crashes. American Journal of Emergency
    Medicine. 2001;19 (7):575-578.
  11. Hassoun HT, Weisbrodt NW, Kozar RA, Mercer DW, Moody FG, Moore FA. Inducible nitric oxide synthase mediates gut ischemia/reperfusion-induced ileus only after severe insults. J Surg Res.2001;97(2):150-154.
  12. Kozar RA, Kaplan LJ, Cipolla J, Meija J, Haber M. Laparoscopic repair of traumatic diaphragmatic injuries. J Surg Res. 2001;97(2):164-171.
  13. Moore FA, Cocanour CS, McKinley B, Kozar RA, DeSoignie R, VonMaszewski M,
    Weisbrodt N. MMC’s exist after trauma and predict enteral tolerance. J Trauma 2001;51(6):1075-1082.
  14. Garner GB, Ware DW, Cocanour CS, Duke JH, McKinley BA, Kozar RA, Moore FA.
    Vacuum assisted wound closure provides early fascial reapproximation in trauma patients
    with open abdomens. Am J Surg 2001;182(6):630-638.
  15. Hassoun HT, Kone BC, Kozar RA, Lai M, Moore FA. ?-Melanocyte stimulating hormone augments gut ischemia-reperfusion induced heme oxygenase expression. Surgical Forum. 2001; LII:12-14.
  16. Hassoun HT, Zou L, Moore FA, Kozar RA, Weisbrodt NW, Kone C. ?-melanocyte stimulating hormone protects against mesenteric ischemia/reperfusion injury. Am J Physiol.2002; 282:1059-1068.
  17. McKinley BA, Kozar RA, Cocanour CS, Marquez A, Sailors RM, Ware DN, Moore FA. Trauma resuscitation: female hearts respond better. Arch of Surgery 2002; 137(5):578-584.
  18. Kozar RA, McQuiggan MM, Moore EE, Kudsk K, Jurkovich G, Moore FA. Postinjury enteral tolerance is reliably achieved by a standardized protocol. J Surg Res. 2002; 104(1):70-75.
  19. Kozar RA, Sen H, Hassoun HT, DeSoignie R, Moore FA. Specific enteral nutrients alter mucosal blood flow during gut ischemia/reperfusion. JPEN 2002; 26 (4): 226-229.
  20. Kozar RA, Schultz SG, Hassoun HT, DeSoignie R, Weisbrodt NW, Haber MH, Moore
    FA. The type of sodium-coupled solute modulates small bowel mucosal injury, transport function and ATP after Ischemia/reperfusion injury in rats. Gastroenterology 2002;123(3):810-6.
  21. Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Ware DN, Holcomb JB, Moore FA. Secondary compartment syndrome: an elusive complication of shock resuscitation. Am J Surg.
    2002; 184 (6) 538-43; discussion 543-4.
  22. McKinley BA, Cocanour CS, Kozar RA, Ware DN, Sailors RM, Marquez A, Moore FA. Normal vs supranormal O2 delivery goals in shock resuscitation: the response is the same. J Trauma. 2002 (53) 825-32.
  23. Hassoun HT, Kozar RA, Kone BC, Safi HJ, Moore FA. Intraischemic hypothermia differentially modulates oxidative stress proteins during mesenteric ischemia/reperfusion. Surgery 2002; 132 (2): 369-76.
  24. Balogh Z, McKinley BA, Holcomb JB, Miller CC, Cocanour CS, Kozar RA, Moore FA. Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of bad outcome. J Trauma. 2003; 54 (5): 848-59.
  25. Holcomb JB, McMullin NR, Kozar RA, Lygas MH, Moore FA: Morbidity from rib fractures increases after age 45. J Am Coll Surg 2003; (196) 549-555.
  26. Mangram A, Kozar RA, Gregoric I, Grant, P, Cocanour CS, Moore FA:Unsuspected blunt cardiac injuries that required operative intervention. J. Trauma. 2003; 54 (2) 286-288.
  27. Attuwaybi BO, Hassoun H, Kozar RA, Moore FA. Hypothermia protects against gut ischemia-reperfusion (I/R) induced impaired intestinal transit by inducing heme oxygenase-1 (HO-1). J Surg Res. 2003;115(1):48-55.
  28. Kozar RA, Lucci A, Azzizadeh A, Miller CC, Cocanour CS, Potts J, Fischer C, Brundage SI. A brief intervention by surgeons can influence medical students towards a career in surgery. J Surg Res. 2003; 3 (1) 166-169.
  29. Zsolt B, McKinley B, Cocanour C, Kozar RA, Valdivia A, Sailrs RM, Moore FA.
    Supra-normal trauma resuscitation causes more cases of abdominal compartment syndrome.
    Archives Surg. 2003;138 (6) 637-642.
  30. Balogh Z, McKinley B, Cocanour C, Kozar RA, Cox C, Moore FA. Patients with impending abnormal compartment syndrome do not respond to early volume loading. Amer J Surg. 2003;186(6)602-608.
  31. Balogh Z, McKinley B, Cox C, Allen S, Cocanour S, Kozar RA, Weisbrodt N, Moore FA. Abdominal compartment syndrome: A modifiable link between traumatic shock and multiple organ failure. Shock. 2003;20 (6) :483-492.
  32. Suliburk JW, Ware DN, Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Moore FA, Ivatury RR. Vacuum-assisted wound closure achieves early fascial closure of open abdomens after severe trauma. J Trauma. 2003;55 (6):1155-1160; discussion 1160-1161.
  33. Kozar RA, Holcomb JB, Macatis J, DeSoignie R, Moore FA. Superior mesenteric artery occlusion (SMAO) models shock-induced gut ischemia/reperfusion. J Surg Res. 2004; 116(1):145-150.
  34. Attuwaybi B, Kozar RA, Gates KS, Moore-Olufemia S, Sato N, Weisbrodt NW, Moore FA. Hypertonic saline prevents inflammation, injury, and impaired intestinal transit after gut ischemia/ reperfusion by inducing heme oxygenase 1 (HO-1) enzyme. J Trauma. 2004;56:749-759.
  35. Kozar RA, Anderson K, Chaves-Escobar S, Theil M, Brundage S. Preclinical students: Who are surgeons? J Surg Res. 2004; 119:113-116.
  36. Kozar RA, Schultz SG, Bick RJ, Poindexter BJ, DeSoignie R, Moore FA. Enteral glutamine but not alanine maintains small bowel barrier function after ischemia/reperfusion injury in rats. Shock 2004; 21 (5): 433-437.
  37. Attuwaybi BO, Kozar RA, Moore-Olufemi SD, Sato N, Hassoun HT, Weisbrodt NW,
    Moore FA. Heme Oxygenase-1 Induction by hemin protects against gut ischemia/reperfusion injury. J Surg Res. 2004;118:53-57.
  38. Marr AB, Moore FA, Sailors M, Valdivia A, Selby J, Kozar RA, Cocanour C, McKinley BA. Preload Optimization using. “Starling Curve” Generation during shock resuscitation: Can it be done? Shock 2004; 21(4): 300-305.
  39. Brundage SI, Lucci A, Miller CC, Azizzadeh A, Spain DA, Kozar RA. Potential targets to encourage a surgical career. J Amer Coll Surg In press.
  40. Kozar RA, Schultz SG, Verner-Cole E, Bick R, DeSoignie R, Poindexter B, Moore FA. Enteral arginine, an immune enhancing agent, impair gut barrier function following mesenteric ischemia/reperfusion. J Trauma. 2004; 56:1150-1156.
  41. Sato N, Moore FA, Smith MA, Zou L, Moore-Olufemi S, Schultz SG, Kozar RA. Immune enhancing enteral nutrients differentially modulate the early pro-inflammatory transcription factors mediating gut ischemia/reperfusion. J Trauma. In press
  42. Marr AB, McQuiggan MM, Kozar R, Moore FA. Gastric feeding as an extension of an established enteral nutrition protocol. Nutrition in Clinical Practice. 2004; 19(5):504-510.
  43. Tyroch AH, McGuire EL, McLean SF, Kozar RA, Gates K, Kaups KL, Cook C, Griswold JA, Sue LA, Craun M, Price J. The association of Chance Fractures and intra-abdominal injuries revisited: A multicenter review. Amer Surg. In press.
  44. Moore-Olufemi S, Kozar RA, Moore FA, Sato N, Hassoun HT, Cox CS, Kone BC. Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury. Shock. 2005; 23(3): 258-263.
BOOK CHAPTERS
  1. Kozar RA, Roslyn JJ: Appendix. In Schwartz SI (Ed.): Principles of Surgery, 7th edition. McGraw-Hill, Inc., 1999: 1383-1394.
  2. Kozar RA, Cipolla J: Chylothorax. In Plantz S (Ed): Medicine, Ob/Gyn, Psychiatry, and Surgery. On-line reference text. (http://www.emedicine.com). Boston Medical Publishers.
  3. Kozar RA, McQuiggan MM, Moore FA. Nutritional Support of Trauma Patients. In Shikora SA, Martindale RG, Schwaitzberg SD (Eds.): Nutritional Considerations in the Intensive Care Unit. Science, Rationale, and Practice. Kendall/Hunt Publishing Co., Dubuque, IO, 2002:229-244.
  4. Kozar RA, Moore FA,: Postinjury Multiple Organ Failure. In Moore EE, Feliciano DV, Mattox KL (Eds.): Trauma Handbook, 4th edition. McGraw-Hill, Inc., 2002: (56) 501-506.
  5. Kozar RA, Haenel JB, Moore FA. Flail Chest and Pulmonary Contusion. In Parsons PE, Wiener-Kronish JP (Eds.): Critical Care Secrets, 3rd edition, Lippincott, 2003: 403-408.
  6. Kozar RA, McQuiggan MM, Moore FA. Surgical Nutrition. In Miller T (Ed): Modern Surgical Care: Physiologic Foundations and Clinical Applications, 3rd Edition, in press.
  7. Kozar RA, McQuiggan MM, Moore FA. Trauma. In Rolandelli R (Ed): Clinical Nutrition (Volume I): Enteral and Tube Feeding, 4th edition, Saunders, 2004:364-372.
  8. Kozar RA, Moore FA. Fluid and Electrolyte Management of the Surgical Patient. In Brunicardi FC (Eds): Schwartz’s Principles of Surgery, 8th edition, McGraw-Hill, 2005;43-59.
  9. Kozar RA, McQuiggan MM, Moore FA. Trauma In Cresci G (Ed): Nutrition Support in the Critically Ill Patient: A Guide to Practice, CRC Press, in press.
  10. Kozar RA, McQuiggan MM, Moore FA. Trauma. In Merritt R (Ed): A.S.P.E.N. Nutrition Support Practice Manual, 2nd Edition, ASPEN in press.

PRESENTATIONS

  1. Kozar RA, Pownall HJ. Cellular phospholipid efflux. Presented at the Aspen Bile Salt Meeting, Aspen, CO, August 1991.
  2. Kozar RA, McKeone BJ, Pownall HJ. Mechanism of cellular phospholipid efflux. Presented at the Association for Academic Surgery, Montreal, Quebec, Canada, November 1992
  3. Kozar RA, McKeone BJ, Pownall HJ. Free radical-induced alterations in endothelial cell function. Presented at the Resident’s Section of Society of University Surgeons,
    Cincinnati, OH, February 1992.
  4. Kozar RA, Harada R, Jaffe F, Cindrick L, White JV. Carbon dioxide angioscopy: Hemodynamic and hemorrheologic responses to large volume CO2 insufflation of the arterial tree. Presented at the Eastern Vascular Society, Montreal, Quebec, Canada, May 1994.
  5. Kozar RA, White JV, Pownall HJ. Reverse cholesterol transport: The mechanism of phospholipid exchange between cell membranes and high density lipoprotein. Presented at the Delaware Valley Vascular Society, Philadelphia, PA, September 1994.
  6. Trooskin SZ, Kozar RA, Blank-Reid CA, Santora TA, Talucci, RC, DeSantis D, Townsend RN. Gender issues in trauma admission: The neglected elderly female. Oral Presentation. Philadelphia Academy of Surgery, Philadelphia, PA, September 1996.
  7. Fuchs B, Kozar RA, Smull G, Chang B, McMaster J, Getsy J, Talucci RC: Role of
    Under-Appreciation of Sleep Disorders as a Cause of Motor Vehicle Crashes. Presented
    at the Pennsylvania Division for the American Trauma Society's Annual Conference, Hershey, PA. April 1997.
  8. Kozar RA, Abedin ZR, Abedin MZ, Trooskin SZ. Expression of epidermal growth factor in Type II Pneumocytes:
    A potential mechanism for recovery from acute lung injury. Presented at Biomedicine '98. May 1-3, 1998.
  9. Kaplan LJ, Kozar RA, Bailey H, Blank-Reid C, Santora TA, Talucci RC, Trooskin SZ. The challenge of pregnant trauma patients: Insight gained from review of a state trauma registry. Presented at the American Association for the Surgery of Trauma. September 1998.
  10. Hassoun HT, Weisbrodt N, Moody FA, Kozar R, Grossie VB, Moore FA. Nitric Oxide synthetase II is upregulated in ileus after intraperitoneal lipopolysaccharide but not gut ischemia/reperfusion. Presented at the Society of University Surgeons, February 2000, Toronto, Canada.
  11. Cipolla J, Kozar RA, Satz WA, Kaplan LJ. Mass transit strike hits cyclists. Presented at
    the meeting of the Society of Academic Emergency Medicine, May 2000, San Francisco, CA.
  12. Kozar RA, Schultz SG, Weisbrodt N, DeSoignie R, Hassoun HT, Moore FA. Intraluminal nutrients enhance gut ischemia/reperfusion injury. Presented at the Shock Society, June 2000, Snowbird, Utah.
  13. Kozar RA, Kaplan LJ, Cipolla J, Meija J, Haber M. Laparoscopic repair of traumatic diaphragmatic injuries. Presented at the 34th Annual Meeting of the Association for Academic Surgery, November 2-4, 2000, Tampa, Florida.
  14. Hassoun HT, Weisbrodt NW, Kozar RA, Mercer DW, Moody FG, Moore FA. Inducible nitric oxide synthase mediates impaired small intestinal transit after severe gut ischemia/reperfusion. Presented at the 34th Annual Meeting of the Association for Academic Surgery, November 2-4, 2000, Tampa, Florida.
  15. Kozar RA, Hu S, Schultz SG, Hassoun HT, Moore FA. Specific enteral nutrients alter
    mucosal blood flow during gut ischemia/reperfusion. Presentation at the 25th Clinical Congress
    of the American Society for Parenteral and Enteral Nutrition , January 2001, Chicago, Illinois.
  16. Hassoun HT, Kozar RA, DeSoignie R, Thorpe L, Kone BC, Miller CC, Safi HJ, Moore FA. Intraischemic topical hypothermia prevents intestinal mucosal injury during mesenteric ischemic/reperfusion. Presented at the Southern Association for Vascular Surgery, Puerto Rico, January 2001.
  17. Mangram A, Kozar RA, Gregoric I, Grant P, Moore FA. Unsuspected fracture penetrations of the heart. Presented at the 31st Annual Meeting of the Western Trauma Association, Big Sky, Montana, Feb. 2001.
  18. Hassoun HT, Kone BC, Kozar RA, Snuggs M, Phan T, Moore FA. ?-Melanocyte stimulating hormone reduces intestinal NF-?B and gut ischemia/reperfusion injury. Presented at the Society of University Surgeons, February 2001.
  19. Von Maszewski M, Cocanour CS, McKinley B, Kozar RA, DeSoignie R, Weisbrodt N, Moore FA.
    MMC’s exist after trauma and predict enteral tolerance. Presented at the 31st Annual Meeting of the Western Trauma Association, Big Sky, Montana, February 2001.
  20. Kozar RA, Schultz SG, Hassoun HT, DeSoignie R, Moore FA. Intraluminal nutrients alter gut permeability following gut ischemia/reperfusion. Presented at the 24th Annual Conference on Shock. February 2001.
  21. Garner GB, Ware DN, Cocanour CS, Duke JH, McKinley BA, Kozar RA, Moore FA.
    Vacuum assisted wound closure provides early fascial reapproximation in trauma patients with open abdomens. Presented at the Southwestern Surgical Congress, Cancun, Mexico, April 2001.
  22. Hassoun HT, Kone BC, Kozar RA, Lai M, Moore FA. ?-Melanocyte stimulating hormone augments gut ischemia-reperfusion induced heme oxygenase expression. Presented at the American College of Surgeons, October 2001.
  23. Kozar RA, Moore EE, Kudsk K, Jurkovich G, Moore FA. Enteral tolerance following severe trauma is reliably achieved by a standardized protocol. Presented atthe 35th Annual Meeting of the Association of Academic Surgery. November 2001.
  24. McKinley BA, Kozar RA, Cocanour CS, Marquez A, Sailors RM, Ware DN, Moore FA. Trauma resuscitation: female hearts respond better. Presented at the annual meeting of the Western Surgical Association, November 2001.
  25. Hassoun HT, Kozar RA, Kone BC, Safi H, Moore FA. Hypothermia differentially modulates oxidative stress proteins during gut ischemia/reperfusion. Presented at the 63rd Annual meeting of the Society of University Surgeons, February 2002.
  26. Tyroch A, McGuire E, McLean S, Kozar R, Gates K, Kaups K, Cook C, Griswold J, Sue L, Craun M, Prices J. The prognostic significance of Chance fractures and intra-abdominal injuries revisited: a multi-center review. Presented at the 62nd Annual Meeting of the American Association for the Surgery of Trauma, September 2002.
  27. Attuwaybi BO, Hassoun H, Kozar RA, Moore FA. Hypothermia protects against gut ischemia-reperfusion (I/R) induced impaired intestinal transit by inducing impaired intestinal transit by inducing heme oxygenase-1 (HO-1). Presented at the 2002 Annual meeting of the Association for Academic Surgery, November 2002.
  28. Kozar RA, Holcomb JB, Macatis J, DeSoignie R, Moore FA. Superior mesenteric artery occlusion (SMAO) models shock-induced gut Ischemia/reperfuison. Presented at the 2002 Annual meeting of the Association for Academic Surgery, November 2002.
  29. Kozar RA, Lucci A, Azzizadeh A, Miller CC, Cocanour CS, Potts J, Fischer C, Brundage SI. A brief intervention by surgeons can influence medical students towards a career in surgery. Presented at the plenary session of the 2002 Annual meeting of the Association for Academic Surgery, November 2002.
  30. Brundage SI, Lucci A, Miller CC, Azizzadeh A, Kozar RA. Potential targets to encourage a surgical career. Presented at the Western Surgical Association, November 2002.
  31. Zsolt, B., M.D., McKinley, B., Ph.D., Cocanour, C., M.D., Kozar, R., M.D.Ph.D., Valdivia, A., R.N., Sailors,. M., Ph.D., Moore, F., M.D. Supra-Normal Trauma Resuscitation causes more case of abnormal compartment syndrome. Presented at the Western Surgical Association, November 2002.
  32. Kozar RA, Attuwaybi B, Sato N, Moore-Olufemia S, Weisbrodt NW, Moore FA. Hypertonic saline prevents inflammation and impaired intestinal transit after gut ischemia/reperfusion by inducing heme oxgenase 1 (H0-1) enzyme. Presented at the American Association for the Surgery of Trauma, September 2003.
  33. Kozar RA, Schultz SG, Verner-Cole E, Bick R, DeSoignie R, Poindexter B, Moore FA. Enternal arginine, an immune enhancing agent, impair gut barrier function following mesenteric ischemia/reperfusion. 34th Annual Meeting of Western Trauma Association, February 2004.
  34. Sato N, Kozar RA, Lei Z, Weatherall J, Attuwaybi B, Moore-Olufemia S, Moore FA.
    Induction of peroxisome proliferators activated receptor (PPAR) gamma, the Cox-2 inhibitor, NS 398, reverses mesenteric ischemia/reperfusion gut inflammation. Presented at the 65th meeting of The Society of University Surgeons, February 2004.
  35. Kozar RA, Sati N, Lei Z, Smith M, Moore FA. Immune enhancing agents differentially modulate gut injury and inflammation. Presented at the 65th meeting of the Society of The University Surgeons, February 2004.

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INVITED PRESENTATIONS

NATIONAL
  1. Sodium coupled solutes modulate small bowel function after ischemia/reperfusion injury. 64th annual meeting of the Society of University Surgeons, Houston, TX February 2003.
  2. Moderator for the Critical Care session at the 64th annual meeting of the Society of University Surgeons, Houston, TX February 2003.
  3. Early goal-directed monitoring of the trauma patient. Postgraduate course: Resuscitation and the immediate care of the trauma patient. American College of Surgeons, April 2003.
  4. Abdominal Infections. AACP Critical Care Board Review Course, Phoenix, AZ, August 2003.
  5. Nutrition. AACP Critical Care Board Review Course, Phoenix, AZ, August 2003
  6. Moderator for the Education session at the 37th annual meeting of the Association of Academic Surgery, Sacramento, CA, November 2004.
  7. Education Research. Fundamentals of Surgical Research Course. 37th annual meeting of the Association of Academic Surgery, Sacramento, CA, November 2004.
  8. Staying in academics: Learning how to SWIM (surgeon, women, investigator, mom). 37th annual meeting of the Association of Academic Surgery, Sacremento, CA, November 2004.
  9. Moderator for Critical Care Session at the 65th Annual Meeting of the Society of University Surgeons, St.Louis, MO, February 2004.
  10. Role of the Gut in Multiple Organ Failure. 33rd Critical Care Congress of the Society of Critical Care Medicine. February 2004
  11. Abdominal Infections. AACP Critical Care Board Review Course, Orlando, FL, August 2004.
  12. . Nutrition in the ICU. AACP Critical Care Board Review Course, Orlando, FL, August 2004.
  13. ACS Nutrition April 2005 Moderator Critic Care oral poster presentations AAS 2004
REGIONAL
  1. Nutrition in the Surgical ICU. Texas Society for Parenteral and Enteral Nutrition, Dallas, TX, September, 2003.
  2. Enteral Feeding Protocol, Society for Parenteral and Enteral Nutrition, Houston , Texas, April 2004.
LOCAL
  1. Pancreaticoduodenal Trauma. Surgical Grand Rounds, Allegheny University of the Health Sciences, Philadelphia, PA, October 1996.
  2. Pancreatic and Duodenal Trauma. Surgical Grand Rounds, Mercy Catholic Medical Center, Philadelphia, PA, September 1997.
  3. Abdominal Trauma. Surgical Grand Rounds, Crozier Chester Medical Center, Philadelphia, PA, October 1997.
  4. Penetrating Trauma. Division of Emergency Medicine, St. Christopher’s Hospital for Children, Philadelphia, PA, February 1998.
  5. Gut Absorptive Capacity Following Shock-Induced Gut Ischemia. Red Duke Professorship Day, The University of Texas Medical School at Houston , Houston, TX, January 2000.
  6. Effect of Intraluminal Nutrients on Gut Ischemia/Reperfusion. Red Duke Professorship Day, The University of Texas Medical School at Houston, TX, January 2001.
  7. Trauma Critical Care Overview. Department of Emergency Medicine,
    The University of Texas Medical School at Houston, Houston, TX, May 2001.
  8. Intraluminal Nutrients Modulate Gut Ischemia/Reperfusion Injury. Red Duke Professorship Day, The University of Texas Medical School at Houston , Houston, TX, January 2002.
  9. ICU considerations of the morbidly obese. Grand Rounds, Department of Surgery, The University of Texas Medical School at Houston, Houston, TX, January, 2003.
  10. Education Research. Grand Rounds. Department of Surgery, The University of Texas Medical School at Houston, Houston, TX November 2003.

Contact Information

Rosemary Kozar, M.D., Ph.D.
  • Rosemary Kozar, M.D., Ph.D.

  • James H. "Red" Duke, Jr. Professor of Surgery and Chief of Trauma, Memorial Hermann Hospital - TMC

  • Department of Surgery

  • The University of Texas Medical School at Houston
    6431 Fannin, Suite 4.284
    Houston, Texas 77030

  • phone: (713) 500-7244
    fax: (713) 500-7268
    e-mail: Rosemary.A.Kozar
    @uth.tmc.edu

Executive Assistant :

Deanna Congdon