Minimally Invasive Fellowship | The University of Texas Medical School at Houston
Department of Surgery
MIST

Faculty Biography

Department of Surgery,
Division of Elective General Surgery


Donald Patrick Lesslie III, D.O.

Assistant Professor of Surgery
Division of Elective General Surgery
The University of Texas Medical School at Houston

Surgical Oncology and Advanced Minimally Invasive Surgery

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Education

1990-1994 Abilene Christian University
Abilene, Texas
B.S.-Biology

1995-1999 University of North Texas Health Science Center
Fort Worth, Texas
D.O.

Postgraduate Training

1999-2000 Rotating Internship
Doctor’s Hospital
Columbus, Ohio

2000-2003 General Surgery Internship and Residency
University of Texas- Houston
Houston, Texas

2003-2005 Postdoctoral Research Fellowship
Departments of Surgical Oncology and Cancer Biology
University of Texas M. D. Anderson Cancer Center
Houston, Texas

2005-2006 General Surgery Residency
University of Texas- Houston
Houston, Texas

2006-2007 Chief Resident in General Surgery
University of Texas- Houston
Houston, Texas

2007-2009 Surgical Oncology Fellowship
Fox Chase Cancer Center
Philadelphia, Pennsylvania

Advanced Surgical Training

2008 Video-Assisted Thoracic Surgery Course
Covidien Surgical Education
Norwalk, CT
Director: Thomas D’Amico M.D.

2008 Advanced Laparoscopic Colon Surgery Course
New York Presbyterian Hospital – Weill Medical College
New York, NY
Directors: Jeffrey Milsom M.D. and Sang Lee M.D.

2009 Laparoscopic Liver Resection – Master’s Course
Covidien Surgical Education
Norwalk, CT
Director: David Geller M.D.

Licensure/Boards

Texas State Board of Medical Examiners – L7008 (exp. 2/2010)
Commonwealth of Pennsylvania – OS014080 (exp. 10/2010)
American Board of Surgery – Baltimore 9/2007 (exp. 1/2018)

Academic/ Clinical Appointments:

2003-2005 Clinical Specialist
Department of Cardiovascular and Thoracic Surgery
University of Texas M. D. Anderson Cancer Center
Houston, Texas

2004-2005 Clinical Specialist
Department of Critical Care
University of Texas M. D. Anderson Cancer Center
Houston, Texas
-
2007-2009 Clinical Instructor
Department of Surgical Oncology
Fox Chase Cancer Center
Philadelphia, Pennsylvania

2007-2009 Clinical Instructor
Department of General Surgery
Temple University Medical School
Philadelphia, Pennsylvania

2009 - Present Assistant Professor
Department of General Surgery
University of Texas Medical School at Houston
Houston, Texas

Honors and Awards

1992-1994 Dean’s List – Abilene Christian University

1996-1999 Dean’s List – University of North Texas Health Science Center

1997 Outstanding Student in Clinical Pharmacology
University of North Texas Health Science Center

1998 Outstanding Student in Public Health and Preventative Medicine
University of North Texas Health Science Center

1998-1999 Founder’s Guild Scholarship
University of North Texas Health Science Center

2003-2005 NIH T32 – 09599 Grant Recipient
2005 American Society of Clinical Oncology Merit Award

2007 American College of Surgeons, South Texas Chapter
Surgical Jeopardy Champion

Professional Memberships and Committees

American College of Surgeons, Associate
American Association for Cancer Research, Associate
American Society of Clinical Oncology, Associate
Society of Surgical Oncology, Associate
Society for Surgery of the Alimentary Tract, Member
American Medical Association
Texas Medical Association
Harris County Medical Society

Publications - Articles in Refereed Journals

  1. Lesslie DP 3rd and Gallick GE. Src Family Kinases as Regulators of Angiogenesis: Therapeutic Implications. Current Cancer Therapy Reviews, 1(1): 45-51, 2005.
  2. Trevino JG, Summy JM, Gray MJ, Nilsson MB, Lesslie DP 3rd, Baker CH, Gallick GE. Expression and Activity of Src Regulate Interleukin-8 Expression in Pancreatic Adenocarcinoma Cells: Implications for Angiogenesis. Cancer Research. 65(16): 1714-22, 2005.
  3. Summy JM, Trevino JG, Lesslie DP 3rd, Baker CH, Shakespeare WC, Yang Y, Sundaramoorthi R, Metcalf CA 3rd, Keats JA, Sawyer TK, Gallick GE. AP23846, a Novel and Highly Potent Src Family Kinase Inhibitor, Reduces VEGF and IL-8 Expression in Human Solid Tumor Cell Lines and Abrogates Downstream Angiogenic Processes. Molecular Cancer Therapeutics. 4(12): 1900-11, 2005.
  4. Trevino JG, Summy JM, Lesslie DP 3rd, Lee FY, Hong DS, Donato NJ, Baker CH, Gallick GE. Inhibition of Src Expression and Kinase Activity Inhibits Development of Metastases of Human Pancreatic Adenocarcinoma Cells in a Nude Mouse Model. American Journal of Pathology. 168(3): 962-72, 2006.
  5. Lesslie, DP 3rd, Summy, JM, Parikh, NU, Fan F, Trevino JG, Sawyer TK, Metcalf CA 3rd, Shakespeare WC, Hicklin DJ, Ellis LM, Gallick GE. Vascular Endothelial Growth Factor Receptor-1 Mediates Migration of Human Colorectal Carcinoma Cells By Activation of Src Family Kinases. British Journal of Cancer. 94(11): 1710-17, 2006.
  6. Trevino JG, Gray MJ, Summy JM, Nawrocki ST, Lesslie DP 3rd, Evans DB, Chiao PJ, McConkey DJ, Gallick GE. Src, STAT3, and NF-B are Required for Constitutive IL-8 Expression in Human Pancreatic Adenocarcinoma Cells. Angiogenesis. 9(2): 101-10, 2006.
  7. Bauer TW, Somcio RJ, Fan F, Liu W, Johnson M, Lesslie DP 3rd, Evans DB, Gallick GE, Ellis LM. Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Molecular Cancer Therapeutics. 5(7): 1676-82, 2006.
  8. Kopetz S*, Lesslie, DP 3rd *, Dallas NA, , Park SI, Johnson M, Parikh NU, Kim MP, Abbruzzese JL, Ellis LM, Chandra J, Gallick GE. Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Cancer Cells is Mediated by Reactive Oxygen Species. Cancer Research. In Press. (* equal contribution)
  9. Lesslie, DP 3rd, Parikh, NU, Shah, A, Summy, JM, Trevino, JG, Lee, FY, Hong DS, Donato NJ, Gallick, GE. SRC Kinase Inhibition by Dasatinib (BMS-354825) Reduces Tumor Formation and Prevents Malignant Ascites in a Murine Model of Carcinomatosis. Manuscript in preparation.

Published Abstracts/ Presentations

  1. Lesslie, DP 3rd, Hicklin, DJ, Sawyer, TK, Shakespeare, WC, Ellis, LM, Gallick, GE. Vascular endothelial growth factor receptor-1 (VEGFR-1) signaling promotes colon cancer cell migration via a Src family kinase dependent mechanism. Proceedings of the 2005 Gastrointestinal Cancers Symposium, A274, 2005.
  2. Lesslie, DP 3rd, Ellis, LM, Hicklin, DJ, Sawyer, TK, Shakespeare, WC, Gallick, GE. VEGFR-1 signaling in human colorectal carcinoma: Role for Src in VEGF-induced migration. Annals of Surgical Oncology, 12(2):8:S10, 2005.
  3. Lesslie, DP 3rd, Langley, RR, Gallick, GE. Src regulates angiogenesis induced by human colorectal carcinoma cells. Proceedings of the American Association for Cancer Research 96th Annual Meeting, A2024, 2005.
  4. Lesslie, DP 3rd, Hicklin, DJ, Ellis, LM, Gallick, GE. Src family kinases and VEGFR-1 are required for VEGF-induced migration in human colorectal carcinoma cells. Proceedings of the American Association for Cancer Research 96th Annual Meeting, A5542, 2005.
  5. Trevino, JG, Summy, JM, Lesslie, DP 3rd, Lee, FY, Donato, NJ, Baker, CH Gallick, GE. Inhibition of Src Expression/Activity Delays Development of Metastases in Human Pancreatic Adenocarcinoma Cells, American College of Surgeons (ACS) 91st Annual Clinical Congress, Surgical Forum Program, 2005-157.
  6. Lesslie, DP 3rd, Fan F, Trevino JG, Sawyer TK, Metcalf CA 3rd, Shakespeare WC, Hicklin, DJ, Ellis LM, Gallick GE. Vascular Endothelial Growth Factor Receptor-1 Mediates Migration of Human Colorectal Carcinoma Cells By Activation of Src Family Kinases. American College of Surgeons, South Texas Chapter. 2006.
  7. Vercruysse, GA, Lesslie, DP 3rd. Delayed Cardiac Tamponade Following Blunt Thoracic Trauma. American College of Surgeons, South Texas Chapter. 2006.
  8. Lesslie, DP 3rd, Shah, A, Summy, JM, Trevino, JG, Lee, FY, Hong DS, Donato NJ, Gallick, GE. Combined Activity of Oxaliplatin and Dasatinib (BMS-354825) in an Orthotopic Model of Metastatic Colorectal Cancer. Proceedings of the American Association for Cancer Research 97th Annual Meeting, A4745, 2006.
  9. Summy JM, Trevino JG, Lesslie DP 3rd, Lee FY, Hong DS, Donato NJ, Baker CH, Gallick GE. Inhibition of Src Expression and Kinase Activity Inhibits Development of Metastases of Human Pancreatic Adenocarcinoma Cells in a Nude Mouse Model. Proceedings of the American Association for Cancer Research 97th Annual Meeting, A5103, 2006.
  10. Lesslie, DP 3rd, Parikh, NU, Shah, A, Summy, JM, Trevino, JG, Lee, FY, Hong DS, Donato NJ, Gallick, GE. Dasatinib (BMS-354825), a Dual SRC/ ABL Tyrosine Kinase Inhibitor, Inhibits Tumor Formation and Prevents Malignant Ascites Formation in a Murine Model of Peritoneal Carcinomatosis. American College of Surgeons (ACS) 92nd Annual Clinical Congress, Surgical Forum Program, 2006.
  11. “Enteral Nutrition in the Surgical Intensive Care Unit”, Grand Rounds Presentation, University of Texas Medical School at Houston. December 7, 2006.
  12. “Targeted Therapy for Advanced Colorectal Cancer: Beyond VEGF and EGFR”, Department of Surgical Oncology Grand Rounds Presentation, Fox Chase Cancer Center. July 29, 2008.
  13. “Combined Modality Therapy for Gallbladder Carcinoma”, Department of Surgical Oncology Grand Rounds Presentation, Fox Chase Cancer Center. December 2, 2008.

Contact Information

Donald Patrick Lesslie III, DO
  • Donald Patrick Lesslie III, DO

  • Assistant Professor of Surgery
    Division of Elective General Surgery
    The University of Texas Medical School at Houston

  • Department of Surgery

  • 6431 Fannin St. MSB 4.020
    Houston, Texas 77030

  • phone: (713) 500-7200
    e-mail: Donald.Lesslie
    @uth.tmc.edu

Executive Assistant:
Kelle Scott