The Department of Surgery at the University of Texas Medical School at Houston
Department of Surgery
MHH Life Flight

Biography

Department of Surgery
Center for Translational Injury Research (CeTIR)


Xiyun Deng, Ph.D.

Research Scientist, Division of Acute Care Surgery
The University of Texas Medical School at Houston

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Education:

1994 MSc - Hunan Medical University, P.R. China
2000 PhD - Hunan Medical University, P.R. China
2005 Postdoctoral - Ohio State University, USA

Academic Appointments

1994-1997 Research Associate and Instructor, Laboratory of Tumor Molecular Biology, Cancer Research Institute, Hunan Medical University, Changsha, Hunan, China.
1997-1998 Visiting Fellow, Laboratory of Molecular Immunoregulation, National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, Maryland, USA.
1998-1999 Visiting Fellow, Medicine Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
1999-2001 Associate Professor, Laboratory of Tumor Molecular Biology, Cancer Research Institute, Hunan Medical University, Changsha, Hunan, China.
2001-2003 Postdoctoral Research Associate, Depts. of Urology and Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA.
2003-2005 Postdoctoral Researcher, Dept. of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
2005-2007 Associate Professor, Laboratory of Tumor Molecular Biology, Cancer Research Institute, Xiangya School of Medicine (formerly Hunan Medical University), Central South University, Changsha, Hunan, China.
2007-present Research Scientist, Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA

HONORS

1986 Provincial Bureau of Health of Hunan Province, China
1994 Li Chenpien Scholarship, Changsha, Hunan, China

PUBLICATIONS

  1. Deng X, Cao Y, Lee LM, Yao KT. Point mutation of the 1.6kb XbaI/EcoRI fragment of the Tx gene in human nasopharyngeal carcinoma. Chin J Oncol 1995; 17(suppl):3-6.
  2. Ren JC, Deng X, Cao Y, Yao KT. Analysis of DNA fragments and polymerase chain reaction products from the Tx gene by capillary electrophoresis with a laser-induced fluorescence detector using no-gel sieving media. Anal Biochem 1996; 233:246-9.
  3. Deng X, Cao Y, Yao KT, Chen SL, Liu BA, He ZD, Cai J. Expression of human immunoglobulin light chains in epithelium and epithelium-derived cancers. In: Advances in Cancer Research in China (Vol III), China Cancer Research Foundation (CCRF), 1997; pp98-100.
  4. Deng X, Cao L, Weng XX, Yao KT, Cai H, Lv XS: Detection of telomerase activity and its clinical significance in colon cancer by PCR-ELISA. Bull Hunan Medical Univ 1998; 23:343-4.
  5. Deng X, Cao Y, Cao L, Lee LM, Yao KT. Point mutation of 2.8 kb EcoRI fragment of the NPC transforming gene in NPC cell lines. Chin Med J 1998; 111:247-9.
  6. Deng X, Cai H, Cao L, Gu HH, Cao Y, Yao KT: Detection of telomerase activity and its clinical significance in colon cancer by PCR-ELISA. Bull Hunan Medical Univ 1998; 23:4-6.
  7. Wang JM, Deng X, Gong W, Su S. Chemokines and their role in tumor growth and metastasis (invited review). J Immunol Methods 1998; 220:1-17.
  8. Deng X, Ueda H, Su SB, Gong W, Dunlop NM, Gao JL, Murphy PM, Wang JM. A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R. Blood 1999; 94(4):1165-73.
  9. Cai H, Lu X, Tang H, Deng X. Detection of telomerase activity in colonic cancer (a preliminary report). Chin J Gen Surgery 1999; 8:291-2.
  10. Su SB, Gong WH, Gao JL, Shen WP, Grimm MC, Deng X, Murphy PM, Oppenheim JJ, Wang JM. T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor. Blood 1999; 93:3885-92.
  11. Liao W, Tang M, Deng X, Cao Y. The Epstein-Barr virus encoded latent membrane protein 1 promotes nuclear factor-kappa B activity in a nasopharyngeal carcinoma cell line. Chin J Virol 2000; 16:198-202.
  12. Wang CX, Deng X, Li XY, Xiao H, Cao Y. Expression of tumor necrosis factor receptor-associated factor 1 in nasopharyngeal carcinoma and paracancerous tissues. Chin J Oncol 2000; 19:856-8.
  13. Wang CX, Li XY, Gu HH, Deng X, Cao Y: Preliminary study on the activation of TRAFs mediated by Epstein-Barr virus encoded LMP1 in nasopharyngeal carcinoma. Virologica Sinica 2001; 16:6-10.
  14. Yin L, Liao W, Deng X, Tang M, Gu H, Li X, Yi W, Cao Y. LMP1 activates NF-kappa B via degradation of I kappa B alpha in nasopharyngeal carcinoma cells. Chin Med J 2001; 114(7):718-22.
  15. Li M, Ren W, Weng XX, Liao W, Xia LQ, Deng X, Cao Y. Nucleotide sequence analysis of a transforming gene isolated from nasopharyngeal carcinoma cell line CNE2: an aberrant human immunoglobulin kappa light chain which lacks variable region. DNA Seq 2001; 12(5-6):331-5.
  16. Liao W, Tang M, Yin L, Deng X, Cao Y: EBV latent membrane protein 1 induces p53 expression via NF-kappaB in nasopharyngeal carcinoma. Chin J Oncol 2001; 23:199-202.
  17. Yang J, Deng X, Gu HH, Xia LQ, Yi W, Cao Y. Epstein-Barr virus latent membrane protein 1 induces the telomerase activity in human nasopharyngeal epithelial cells. Acta Exp Biol 2001; 34(3):207-11.
  18. Deng X, Kim M, Vandier D, Jung YJ, Rikiyama T, Sgagias MK, Goldsmith M, Cowan KH. Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin. Biochem Biophys Res Commun 2002; 296(4):792-8.
  19. Wang C, Deng X, Li X, Gu H, Yi W, Weng X, Xia L, Cao Y. Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus LMP1 via NF-kappa B or AP-1 signaling pathway in nasopharyngeal carcinoma cells. Chin J Oncol 2002; 24(1):9-13.
  20. Tao Y, Deng X, Hu Z, Tang M, Gu H, Yi W, Wang C, Luo F, Cao Y. EB virus encoded latent membrane protein 1 modulates the phosphorylation of epidermal growth factor receptor in nasopharyngeal carcinoma cell line. Chin J Oncol 2002; 24(3):226-9.
  21. Yang J, Deng X, Tang M, Wu SF, Gu HH, Yi W, Cao Y. Epstein-Barr Virus latent membrane protein 1 induces telomerase activity of nasopharyngeal epithelial cells through NF-kappaB. Prog Biochem Biophys 2002; 29:556-61.
  22. Deng L, Yang J, Zhao XR, Deng X, Zeng L, Gu HH, Tang M, Cao Y. Cells in G2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-kappaB and AP-1. Cell Res 2003; 13(3):187-94.
  23. Yang J, Deng X, Deng L, Gu HH, Yi W, Cao Y. Epstein-Barr Virus LMP1 Activates Human Telomerase Transcription via c-myc Expression. Chin J Virol 2003; 19(3):240-4.
  24. Kim M, Sgagias M, Deng X, Jung YJ, Rikiyama T, Lee K, Ouellette M, Cowan K. Apoptosis induced by adenovirus-mediated p14(ARF) expression in U2OS osteosarcoma cells is associated with increased Fas expression. Biochem Biophys Res Commun 2004; 320(1):138-44.
  25. Yang J, Deng X, Deng L, Gu H, Fan W, Cao Y. Telomerase activation by Epstein-Barr virus latent membrane protein 1 is associated with c-Myc expression in human nasopharyngeal epithelial cells. J Exp Clin Cancer Res 2004, 23(3):495-506.
  26. Song X, Tao YG, Deng X, Jin X, Tan YN, Tang M, Wu Q, Lee LM, Cao Y. Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1. Cell Signal 2004; 16(10):1153-62.
  27. Hu J*, Deng X*, Bian X, Li G, Tong Y, Li Y, Wang Q, Xin R, He X, Zhou G, Xie P, Li Y, Wang JM, Cao Y. The expression of functional chemokine receptor CXCR4 is associated with the metastatic potential of human nasopharyngeal carcinoma. Clin Cancer Res 2005; 11(13):4658-65. (* Equal-contribution first authors)
  28. Dong Z, Bonfil RD, Chinni S, Deng X, Trindade Filho JC, Bernardo M, Vaishampayan U, Che M, Sloane BF, Sheng S, Fridman R, Cher ML. Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue. Am J Pathol 2005; 166(4):1173-86.
  29. Tao Y, Song X, Deng X, Xie D, Lee LM, Liu Y, Li W, Li L, Deng L, Wu Q, Gong J, Cao Y. Nuclear accumulation of epidermal growth factor receptor and acceleration of G1/S stage by Epstein-Barr-encoded oncoprotein latent membrane protein 1. Exp Cell Res 2005; 303(2):240-51.
  30. Deng X, Bhagat S, Dong Z, Mullins C, Chinni SR, Cher M. Tissue inhibitor of metalloproteinase-3 induces apoptosis in prostate cancer cells and confers increased sensitivity to paclitaxel. Eur J Cancer 2006; 42(18):3267-73.
  31. Chinni SR, Sivalogan S, Dong Z, Filho JC, Deng X, Bonfil RD, Cher ML. CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12. Prostate 2006; 66(1):32-48.
  32. Deng X, Tannehill-Gregg S, Nadella MVP, He G, Levine A, Rosol TJ. Parathyroid Hormone-related Protein and Ezrin Are Up-regulated in Human Lung Cancer Bone Metastases. Clin Exp Metastasis 2007; 24(2):107-19.
  33. Zheng H, Li M, Ren W, Zeng L, Liu HD, Hu D, Deng X, Tang M, Shi Y, Gong J, Cao Y. Expression and secretion of immunoglobulin alpha heavy chain with diverse VDJ recombinations by human epithelial cancer cells. Mol Immunol 2007; 44(9):2221-7.
  34. Deng X, He G, Levine A, Cao Y, Mullins C. Adenovirus-mediated Expression of TIMP-1 and TIMP-2 in Bone Inhibits the Growth of Human Prostate Cancer. Int J Cancer 2008; 122(1):209-18.
  35. Cao Y, Liu X, Zhang W, Deng X, Zhang H, Liu Y, Chen L, Thompson EA, Townsend CM Jr, Ko TC. TGF-beta repression of Id2 induces apoptosis in gut epithelial cells. Oncogene. 2009; 28(8):1089-98.
  36. Deng Y, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, Perkins AS, Fields AP, Hellmich MR, Townsend CM Jr, Thompson EA, Ko TC. Identification of a Novel Evi-1 Transcript in Colorectal Cancer. Cancer (submitted)

RESEARCH SUPPORT

  1. Mechanisms and biological significance of cancer cell expression of immunoglobulin (Grant # 39830410)
    Key Program supported by Natural Science Foundation of China (NSFC), 1999-2003
    Role: Participant
  2. Studies on the interactions between Epstein-Barr virus and critical genes involved in nasopharyngeal carcinogenesis（Grant # G1998051201）
    State key basic research development program－973 fund（1999－2003）
    Role: Participant
  3. Identification of nasopharyngeal carcinoma metastasis-related chemokines and their receptors
    Supported by Hunan Province Health Bureau, 2001-2002
    Role: Principal Investigator
  4. Role of the chemokine receptor EBI1/CCR7 in the metastasis of nasopharyngeal carcinoma (Grant # 30170877)
    Supported by Natural Science Foundation of China (NSFC), 2002-2004
    Role: Principal Investigator
  5. Molecular mechanisms by which Epstein-Barr virus-encoded latent membrane protein 1 regulates the activity of chemokine receptor CXCR4 and promotes nasopharyngeal carcinoma metastasis (Grant # 30771966)
    Supported by Natural Science Foundation of China (NSFC), 2008-2010
    Role: Principal Investigator

Contact Information

Xiyun Deng, PhD
  • Xiyun Deng, PhD

  • Research Scientist, Division of Acute Care Surgery

  • Center for Translational Injury Research (CeTIR)

  • The University of Texas Medical School at Houston
    6431 Fannin Street, MSB 4.608
    Houston, Texas 77030

  • phone: (713) 500-7224
    e-mail: Xiyun.Deng@uth.tmc.edu