The Department of Surgery at the University of Texas Medical School at Houston
Department of Surgery
MHH Life Flight

Faculty Biography

Department of Surgery,
Division of Acute Care Surgery,
Trauma and Critical Care


Charles E. Wade, Ph.D.

Professor of Surgery
Division of Acute Care Surgery
The University of Texas Medical School at Houston

Deputy Director - The Center for Translational Injury Research
The University of Texas Health Science Center at Houston

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Education:

1979 - 1982  University of California, San Francisco - Postdoctoral Fellow
1979            Tripler Army Medical Center - Clinical Research Fellow
1979            University of Hawaii School of Medicine - Ph.D., Biomedical Sciences (Physiology)
1975            University of California, Davis - M.A., Physical Education
1972            Occidental College - A.B., Physical Education

PROFESSIONAL EXPERIENCE:

2005 – Present Senior Scientist, U.S. Army Institute for Surgical Research, Fort Sam Houston, TX
2005 – Present Clinical Professor, Department of Surgery, Univ. of Texas Health
Science Center, San Antonio, TX
2004 - 2005 Research Physiologist, U.S. Army Institute for Surgical Research, Fort Sam Houston, TX
1994 - 2004 Senior Scientist, Life Sciences Division, NASA-Ames Research Center, Moffett Field, CA
1991 – 2004 Project Scientist , Space Station Biological Research Project, NASA-Ames Research Center, Moffett Field, CA
1990 - 2004 Contract Office Technical Representative, NASA-Ames Research Center, Moffett Field, CA
2002 - 2003 Division Chief (Acting), Life Sciences Division, NASA-Ames Research Center, Moffett Field, CA
1992 – 1994 Division Chief (Acting), Life Sciences Division, NASA-Ames Research Center, Moffett Field, CA
1990 - 1992 Deputy Division Chief, Life Sciences Division, NASA-Ames Research Center, Moffett Field, CA
1987 - 1990 Hypertonic Saline/Dextran Project Manager, U.S. Army Medical Research and Development Command, Ft. Detrick, MD
1986 - 1990 Assistant Chief, Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, CA1985 - 1990 Contract Officer’s Representative, U.S. Army Medical Research and Development Command, Ft. Detrick, MD
1984 - 1990 Research Physiologist, Division of Military Trauma Research,
Letterman Army Institute of Research, Presidio of San Francisco, CA
1982 - 1984 Chief, Physiology Section, Department of Clinical Investigations, Letterman Army Medical Center, Presidio of San Francisco, CA

Commercial:

1997 - 2003 Biophausia Pharmaceuticals, Uppsala, Sweden. Consultant
1998 - 2000 Resuscitation Solutions Inc., Galveston, TX. Founder and Director of Research and Development
1999 - 2000 Pharmalink AB, Stockholm, Sweden. Consultant
1995 - 1999 Medisan Pharmaceuticals, Piscataway, NJ. Consultant
1991 - 1995 Trauma Products Inc., San Diego CA. Director of Research and Development

RESEARCH SUPPORT

Present:

Principal Investigator (20% time), Technologies in Metabolic Monitoring – Julia Weaver
Fund, A Congressionally Directed Program Jointly Managed by the USA MRMC, NIH, NASA and the Juvenile Diabetes Research Foundation: 2006-2010, $3,400,000 K

Principal Investigator (5% time), Innovative Drugs for the Surviving Blood Loss – MRMC U.S. Army 2008-2010, $1,950,000 K

Principal Investigator (20% time), Characterization and Application of a Large Animal Model of Penetrating Traumatic Brain Injury – MRMC U.S. Army 2010-2012, $2,400,000 K

Co-Principal Investigator (5% time), Vascular and Lymphatic Targeting for the Treatment of Traumatic Injuries-Development and Evaluation in a Swine Model – DARPA 2008-2009, $0.5 K

PROFESSIONAL AND SCIENTIFIC SOCIETIES:

  • • American Association Surgery of Trauma (Honorary)
  • American Burn Association
  • American Physiological Society
  • Shock Society
  • Sigma Xi
  • Society for Experimental Medicine and Biology
  • American Association for the Advancement of Science
  • American College of Sports Medicine (Fellow, 1983)

HONORS AND FELLOWSHIPS:

2007 Order of Military Medical Merit
2003 NASA Exceptional Service Medal
2003 NIH-DOD Working Group on Trauma Research
2002 Invited Professor, University Pierre & Marie Curie, Paris, France
2001 NIH Clinical Trials in Head Injury Study Group
2001 NASA Outstanding Leadership Medal
2000 – 2001 NASA-Ames Associate Fellowship
1990-2004 Numerous NASA performance and group achievement awards
1996, 1997 Visiting Scholar, Marine Biology Laboratory, Woods Hole, MA
1986 - 1991 NRC Research Program Advisor, Letterman Army Medical Center, Presidio of San Francisco, CA
1989 Department of Army Research and Development Award
1984 Presidio of San Francisco-Employee of the Year in the Sciences
1979 - 1982 National Institutes of Health, Postdoctoral Fellowship, Department of Physiology, University of California, San Francisco, CA

SIGNIFICANT APPOINTMENTS:

2007-present Reviewer, DoD Congressional Mandated Research Program
2007-present Reviewer, Orthopedic trauma Research Program Grants
2007-present Reviewer, Director of Defense Research and Engineering National
Security Science and Engineering Faculty Fellowship Competition
2008-2009 Board member, Armed Forces Institute of Regenerative Medicine
2005 NIH-HLB External Review of the Resuscitation Outcomes Consortium
2004 Co-Chair, US Army Trauma Products Line Review
2003 Peer Review, DARPA BAA Metabolic Dominance Panel
2003 Peer Review, NASA Graduate Student Research Program
2003 Peer Review, NASA International Shared Tissue Panel
2003 NIH-DOD Working Group on Trauma Research
2002 Invited Professor, University Pierre & Marie Curie, Paris, France
1988 - 2002 Program Reviewer, American College of Sports Medicine Meeting
1998 - 2000 Veterans Administration Merit Grant Reviewer
2000 Office of Naval Research, Grant Reviewer
1995 - 1998 Chairman, Animal Care and Use Committee, NASA-Ames Research Center, Moffett Field, CA
1991 - 1995 Member, Animal Care and Experimentation Committee, American Physiological Society, Bethesda, MD
1990 - 1994 Panel on Gravitational Biology, American Institute of Biological Sciences
1985 - 1994 Member, Trauma Advisory Board, U.S. Army Medical Research and Development Command
1991 - 1993 Chairman, Animal Care and Use Committee, NASA-Ames Research Center, Moffett Field, CA
1985 - 1990 Member, Institution Review Committee, Letterman Army Medical Center, Presidio of San Francisco, CA
1985 - 1990 Member, Radiation Safety Committee, Letterman Army Medical Center, Presidio of San Francisco, CA
1985 - 1990 Member, Animal Use Committee, Letterman Army Medical Center, Presidio of San Francisco, CA
1989 - 1990 Review Coordinator, National Research Council
1982 - 1984 Member, Human Use Committee, Letterman Army Medical Center, Presidio of San Francisco, CA
1982 - 1984 Member, Clinical Investigation Committee, Letterman Army Medical Center, Presidio of San Francisco, CA

INVITED PRESENTATIONS:

2009 Endpoint in Resuscitation, Houston, TX
2009 NIH CNS and Glycemic Control, Bethesda, MD
2009 Veterans Affairs-Brain at War, San Francisco, CA
2009 Congressional Defense Health board (3 presentations)
2009 British Defense Medical Service Department, London, England
2009 Surgical Grand rounds, UTHSCSA, TX
2008 Department of Physiology, UTHSCSA, TX
2008 NIH Use of Plasma in Resuscitation, Bethesda, MD
2007 Experimental Design and Statistics in Clinical Research
2006 Senate/House Armed Services Committee
2006 DARPA Restorative Injury Repair (RIR)
2006 AstraZeneca Pharmaceuticals, Denmark
2004 Burn, Shock and Trauma Institute, Loyola University, Chicago, IL
2004 World Congress of Anesthesiology, Paris, France
2003 Continuing Medical Education, Bruge, Belgium
2003 University of Lisbon, Lisbon Portugal
2003 Institute for Surgical Research, San Antonio, TX
2003 International Meeting on Adaptive medicine, San Diego, CA
2002 Clinical Research Methodologies in Combat Resuscitation and Casualty Care, Toronto Canada
2002 NATA Meeting: Transfusion alternatives in transfusion medicine, Rome Italy
2002 International Symposium on Intensive Care and Emergency Medicine, Brussels Belgium
2002 Winter Intensive Care Medicine Symposium, Crans Montans Switzerland
2001 Fluid Resuscitation in Combat, Toronto, Canada
2001 3rd Current Controversies in Anesthesiology and Peri-Operative Medicine, Dingle, Ireland
2001 Departments of Anesthesiology and Surgery, Kings University Hospital, London, UK
2001 U.S. Military Fluid Resuscitation Conference, Washington DC, USA
2001 International Trauma Care Conference, Edinburg, Scotland
2001 Royal Military Advisory Committee, Edinburg, Scotland
2000 European Society of Intensive Care Medicine, Rome, Italy.
2000 Founders Day Lecturer, Marine Biological Laboratory, Woods Hole, MA.
2000 NIH Meeting on Head Trauma, Philadelphia, PA.
2000 Integrative Biology of Space Flight, Woods Hole, MA.
2000 NASA Project Management, Virginia Beach, VA.
2000 Office of the Surgeon General, Bonn, Germany.
2000 Invited speaker, Marshall University Medical School, Huntington, WV.
2000 International Union of Physiology, Kyoto, Japan.
2000 Symposium Chair, Experimental Biology 2000, San Diego, CA.
2000 Southern Hospital, Stockholm Sweden.
2000 International Critical Care Meeting, Brussels, Belgium.
2000 Department of Surgery, University of Uppsala, Uppsala, Sweden.
1999 University Hospital, Lund , Sweden.
1999 Danish Medical Society, Copenhagen, Denmark.
1998 European Society of Intensive Care Medicine, Stockholm, Sweden
1998 Critical Care Medicine Society meeting, San Diego, CA
1998 OPRR Animal Use Meeting, Reno, NV
1997 International Critical Care Meeting, Brussels, Belgium.
1997 Scandinavian Anesthesiology Meeting, Stockholm, Sweden.
1997 Swedish Surgical Society, Västeras, Sweden.
1996 NATO Surgical Conference, Stockholm, Sweden.
1996 U.S. Military Special Operations Medical Association, North Carolina
1996 Bodensee Symposium on Microcirculation, Bodensee, Germany.
1996 Department of Surgery, University of Uppsala, Uppsala, Sweden.
1994 Experimental Biology Meeting, Anaheim, CA
1994 International SALT Meeting, Jackson Hole, WY
1990 Session Chairman, SALT IV, Garmish, FDR
1990 Symposium Chairman, FASEB Meeting, Washington, DC
1990 Symposium Chairman, Pre-Meeting, Shock Society, Durango, CO

EDITORIAL RESPONSIBILITIES:

Editorial Boards:

2006-present Editorial Board, Shock
2000 –2006 Editorial Board, Journal of Gravitational Physiology
1998 – 1999 Editorial board, Journal of Applied Physiology
1989 – 1999 Editorial Board, American Journal of Physiology: Regulatory Integrative and Comparative Physiology
1997 – 1999 Editorial Board, American Journal of Physiology: Heart and Circulatory Physiology

Ad hoc Reviewer:

The Lancet; American Journal of Clinical Nutrition; Shock; Journal of the American College of Surgeons; Journal of Trauma Burns; Critical Care; Comparative Physiology; Aviation Space; Environmental Medicine; Journal of Gravitational Physiology; Life Sciences; Neuroscience; Asian Journal of Andrology; Physiology and Behavior; Medicine Science in Sports and Exercise; American Journal of Physiology:Regulatory Integrative; American Journal of Physiology:Endorinology and Metabolism; BMC Emergency Medicine; Journal American Association Laboratory Animal Sciences; American Journal of Physiology: Cell Physiology; Journal of Experimental Biology; BioMed Central Infectious Diseases; Journal of Applied Physiology; Physiological Genomics; Journal of Diabetes Science and Technology

THESIS COMMITTEES

Dr. Dan Drobin, M.D/Ph.D Soder Hospital – Karolinska Institute, Stockholm, Sweden, January 2001 (Discussant)
Dr. Rudy M. Ortiz, Ph.D, University of California, Santa Cruz, CA, USA, June 2001
Ms. Mary E. Miller, M.S. California State University, San Jose, CA, USA, August 2001
Dr. Christophe Masseguin, Universite Jean Monnet – Saint Etienne, Saint Etienne, France, June 2002 (Rapportcur)
Dr. Liz Warren, Ph.D. < University of California, Davis, CA, USA, June 2003
Dr. Audrey Bergouignan, Universite Louis Pasteur – Strasbourg, Strasbourg, France, July, 2008 (Rapportcur)
Dr. Heather Pidcoke, M.D., University of Texas Health Science Center, San Antonio, Texas: Ph.D. Candidate in Physiology

PUBLICATIONS

BOOKS EDITED:

Claybaugh, J.C., and C.E. Wade. Hormonal Regulation of Fluids and Electrolytes: Environmental Effects. Plenum Press, New York, 1989.

BOOK CHAPTERS:
  1. Spitz, I.M., C.E. Wade, D.T. Krieger, P.L. Lahteenmaki, and C.W. Bardin. Effect of RU486 on the pituitary adrenal axis in the dog. In: The Antiprogestin Steroid RU486 `and Human Fertility Control. E.E. Ballieu and S. Seal, eds. Plunum Publishing: New York, NY, 1985, pp. 315–329.
  2. Wade, C.E., J.P. Hannon, C.A. Bossone, M.M. Hunt, and W.G. Rodkey. Cardiovascular and hormonal responses of conscious pigs during physical restraint. In: Swine in Biomedical Research. M.E. Tumbleson, ed. Plenum Publishing: New York, NY, Vol. III, 1986, pp. 1395–1404.
  3. Wade, C.E., B.J. Freund, and J.R. Claybaugh. Fluid and electrolyte homeostasis during and following exercise. In: Hormonal Regulation of Fluid and Electrolytes: Environmental Effects. J. R. Claybaugh and C.E. Wade, eds. Plenum Press: New York, NY, 1989, pp. 1–44.
  4. Claybaugh, J.R., C.E. Wade, and S.A. Cucinell. Fluid and electrolyte balance and hormonal responses to the hypoxic environment. In: Hormonal Regulation of Fluid and Electrolytes: Environmental Effects. J.R. Claybaugh and C.E. Wade, eds. Plenum Press: New York, NY, 1989, pp. 187–215.
  5. Wade, C.E., and B.J. Freund. Hormonal control of blood volume during and following exercise. In: Fluid Homeostasis During Exercise. C.V. Gisolfi and D.R. Lamb, eds. Benchmark Press, Inc.: Indianopolis, IN, 1990, pp. 206–245.
  6. Grymes, R.A., C.E. Wade, and J. Vernikos. Biomedical issues in the exploration of Mars. In: Strategies for Mars: a guide to human exploration. C.R. Stoker and C. Emmart, eds. Americal Astronautical Society, San Diego, CA 1996, pp. 225–239.
  7. Wade, C.E. Hormonal control of body fluid balance. In: Body Fluid Balance: Exercise and Sport. E.R. Buskirk and S.M. Phul, eds. CRC Press: Boca Raton, FL, 1996, pp. 53–74.
  8. Wade C.E. Space Biology. In: McGraw-Hill Encyclopedia of Science and Technology 9th Edition. McGraw-Hill, New York, NY 2002, pp. 63-70.
  9. Halstead, T.H. and C.E. Wade Weightlessness. In: McGraw-Hill Encyclopedia of Science and Technology 9th Edition. McGraw-Hill, New York, NY 2002, pp. 502-506.
  10. Wade C.E., Ritenour A.E, Eastridge B.J., Young L.A., Blackbourne L.H., Holcomb J.B. Explosion injuries treated at combat support hospitals in the global war on terrorism. In: Explosion and Blast-Related Injuries. J. Atkins and N. Elsayed, eds. Elsevier Inc., Academic Press, June 2008 .
  11. Wade C.E. and M.A. Dubick. Hypertonic saline solutions for the initial treatment of patients with traumatic injuries. In: Alternatives to Blood Transfusion in Transfusion Medicine. 2nd Edition. Chapter 15. A. Maniatis, P. Van der Linden, J.F. Hardy, eds. Wiley-Blackwell Publishing, 2010, pp. 179-193
JOURNAL PUBLICATIONS:
  1. Morton, M., C. Maxwell, and C. Wade. Body size, body composition, and behavior of juvenile Belding ground squirrels. Great Basin Naturalist 34:121–134, 1974.
  2. Wade, C.E. The effects of a season's training on the body composition of female college swimmers. Res. Q. Am. Assoc. Health Phys. Educ. 45:292–295, 1976.
  3. Wade, C.E., and J. Veghte. Thermographic evaluation of the relative heat loss by area in man after swimming. Aviat. Space Environ. Med. 48:16–18, 1977.
  4. Dressendorfer, R., C.E. Wade, and E. Bernauer. Combined effects of breathing resistance and hyperoxia on aerobic work tolerance. J. Appl. Physiol. 42:444–448, 1977.
  5. Wade, C.E., E. Hayashi, T. Cashman, and W. Beckman. The incidence of dysbaric osteonecrosis in Hawaii's diving fisherman. Undersea Biomed. Res. 5:137–147, 1978.
  6. Wade, C.E., S. Dacany, and R. Smith. Regional heat loss in man during total body immersion in 25°C degrees water. Aviat. Space Environ. Med. 50:590–593, 1979.
  7. Treffene, R., C. Craven, K. Hobbs, and C.E. Wade. Swimming performance control using plasma lactate and heart rate measurements. Int. Swimmer June:19–21, 1979.
  8. Wade, C.E., E. Bannister, D. Baker, and Y.C. Lin. Absence of the arrhythmic effects of helium in patients with spontaneous premature ventricular beats at rest. Undersea Biomed. Res. 6:313–318, 1979.
  9. Wade, C.E., and J.R. Claybaugh. Plasma renin activity, vasopressin concentration, and urinary excretory responses to exercise in man. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49:930–936, 1980.
  10. Wade, C.E., R.H. Dressendorfer, J.C. O’Brien, and J.R. Claybaugh. Renal function, aldosterone and vasopressin excretion following repeated long distance running. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50:709–712, 1981.
  11. Bie, P., C.E. Wade, L.C. Keil, and D.J. Ramasay. Effects of osmotic stimulation on the concentration of vasopressin in jugular and peripheral venous plasma. Adv. Physiol. Sci.Vol II, Kidney and Body Fluids. L. Takacs, ed., Pergamon, Press, Oxford, 1981.
  12. Dressendorfer, R.H., C.E. Wade, and E.A. Amsterdam. Development of pseudoanemia in marathon runners during a 20 day road race. J. Am. Med. Assoc. 246:1215–1218, 1981.
  13. Dressendorfer, R.H., C.E. Wade, C.E. Hornick, and E.A. Amsterdam. High density lipo protein cholesterol in marathon runners during a 20 day road race. J. Am. Med. Assoc. 247:1715–1717, 1982.
  14. Dressendorfer, R.H., C.E. Wade, C.E.L. Keen, and J.H. Scaff. Blood mineral levels in marathon runners during a 20 day road race. Physicians in Sports Medicine 10:113–118, 1982.
  15. Wade, C.E., P. Bie, L.C. Kiel, and D.J. Ramsay. Effects of hypertonic intracarotid infusions on plasma vasopressin concentration. Am. J. Physiol. 243:E287–E392, 1982.
  16. Claybaugh, J.R., C.E. Wade, A.K. Sato, S.A. Cucinell, J.C.Lane, and J.T. Maher. Antidiurectic hormone responses to eucapnic and hypocapnic hypoxia in humans. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 53:815–823, 1982.
  17. Wade, C.E., R.H. Dressendorfer, J.C. O’Brien, and J.R. Claybaugh. Overnight urinary findings during a 500 km road race over 20 days. J. Sports Med. Physical Fitness 22:371–376, 1982.
  18. Wade, C.E., P. Bie, L.C. Kiel, and D.J. Ramsay. Osmotic control of vasopressin in the dog. Am. J. Physiol. 243:E287–E292, 1982.
  19. Keller-Wood, M.E., C.E. Wade, J. Shinsako, L.C. Keil, G. Van Loon, and M.F. Dallman. Insulin-induced hypoglycemia in conscious dogs: II Effect of maintaining carotid arterial glucose levels on ACTH, epinephrine and vasopressin responses. Endocrinology 112:624–632, 1983.
  20. Dressendorfer, R.H., C.E. Wade, and J.H. Scaff. Renal function during short-term and prolonged stress in coronary heart disease patients. Cardiac Rehabil. 3:575–582, 1983.
  21. Thrasher, T.N., M. Moore-Gillon, C.E. Wade, L.C. Keil, and D.J. Ramsay. Inappropriate drinking and secretion of vasopressin after caval constriction in dogs. Am. J. Physiol. 244:R850–R856, 1983.
  22. Winkel, C.A., C.E. Wade, D.L. Danley, P.C. McDonald, and M.L. Casey. Conversion of progesterone to deoxycorticosterone in guinea pig spleen: an animal model for the study of steroid 21-hydroxylase activity in extra-adrenal sites. J. Steroid Biochem. 19:1635–1635, 1983.
  23. Wade, C.E., L. Keil, and D.J. Ramsay. Role of volume and osmolality in the control of plasma vasopressin in dehydrated dogs. Neuroendocrinology 37:348–353, 1983.
  24. Dressendorfer, R.H., and C.E. Wade. Chronic muscle soreness and serum creatinine kinase elevation in long-distance runners. Physicians and Sports Medicine 11:116–130, 1983.
  25. Thrasher, T.N., C.E. Wade, L.C. Keil, and D.J. Ramsay. Sodium balance and aldosterone during dehydration and rehydration in the dog. Am. J. Physiol. 247:R76–R83, 1984.
  26. Wade, C.E. Response, regulation, and actions of vasopressin during exercise: a review. Medicine Science in Sport and Exercise 16:506–511, 1984.
  27. Lindberg, J., W. Fears, M. Hunt, M. Powell, D. Boll, and C.E. Wade. The effect of exercise-induced amenorrhea on bone density. Ann. Int. Med. 101:647–648, 1984.
  28. Cucinell, S.A., S. Wan, J. O’Brien, and C.E. Wade. Amylase excretion after exercise. Am. J. Gastro. 79:619–622, 1984.
  29. Geelen, G., L.C. Keil, S.E. Kravik, C.E. Wade, T.N. Thrasher, P.R. Barnes, G. Pyka, C. Nesvig, and J.E. Greenleaf. Effects of drinking on plasma vasopressin, renin and aldosterone in dehydrated humans. Am. J. Physiol. 247:R968–R971, 1984.
  30. Dressendorfer, R.H., C.E. Wade, and J.H. Scaff. Increased morning heart rate: a valid sign of overtraining in long-distance runners. Physician and Sports Medicine 13:77–88, 1985.
  31. Raff, H., J. Shinsako, C.E. Wade, L.C. Keil, and M.F. Dallman. The effect of volume expansion on the adrenocortical sensitivity to adrenocorticotropin and angiotensin II in conscious dogs. Am. J. Physiol. 249:R611–R616, 1985.
  32. Wade, C.E. Pituitary and adrenal hormone responses to intravenous naloxone in euhydrated and dehydrated conscious dogs. Am. J. Physiol. 249:E634–E638, 1985.
  33. Wade, C.E., L.A. Hill, M.M. Hunt, and R.H. Dressendorfer. Plasma aldosterone and renal function in marathon runners during a 20 day road race. Eur. J. Appl. Physiol. 54:456–560, 1985.
  34. Buckner, F.S., F.N. Chen, C.E. Wade, and W.F. Ganong. Centrally administered inhibitors of the generation and action of angiotension II do not attentuate the increase ACTH secretion produced by ether stress in rats. Neuroendocrinology 42:97–101, 1986.
  35. Wade, C.E., L.C. Keil, and D.J. Ramsay. Effects of sodium depletion and angiotension II on osmotic regulation of vasopressin. Am. J. Physiol. 250:R287–R291, 1986.
  36. Kilbride, H.W., and C.E. Wade. Birthweights for gestational age of military-dependent infants born at sea level. J. Perinatology 6:10–13, 1986.
  37. Harrison, M.H., G. Geelan, L.C. Keil, C.E. Wade, L.C. Hill, and J.E. Greenleaf. Hydration status and plasma vasopressin, renin, and aldosterone responses to head-up tilt. Aviat. Space Environ. Med. 57:420–425, 1986.
  38. Wade, C.E., and M.M. Hunt. Drinking and subsequent suppression of vasopressin is unaltered by naloxone in dogs. Pharmacol. Biochem. Behavior. 24:1129–1132, 1986.
  39. Rumisek, J.D., C.E. Wade, D.E. Brooks, C.V. Okberberg, M.J.Barry, and J.S. Clarke. Heat-denatured albumin coated dacron vascular grafts: physical characteristics and in vivo performance. J. Vascular Surgery 4:136–143, 1986.
  40. Kravik, E.E., L.C. Keil, G. Geelen, C.E. Wade, P.R. Barnes, W.A. Spaul, C.A. Elder, and J.E. Greenleaf. effect of anti-gravity suite on cardiovascular, PRA, and PVP responses in humans. J. Appl. Physiol. 61:766–774, 1986.
  41. Harrison, M.H., L. Keil, C.E. Wade, J. Silver, G. Geelen, and J.E. Greenleaf. Effect of hydration status on plasma volume and endocrine responses to water immersion. J. Appl. Physiol. 61:1410–1417, 1986.
  42. Lindberg, J.S., M.R. Powell, M.M. Hunt, D.E. Ducey, and C.E.Wade. Increased vertebral bone mineral in response to reduced exercise and increased calcium intake in amenorrheic runners. Western J. Med 146:39–42, 1987.
  43. Harrison, M.H., J. Silver, L.C. Keil, C.E. Wade, and J.E. Greenleaf. Plasma volume and endocrine responses to water immersion with intermittent positive pressure breathing. Aviat. Space Environ. Med. 58:424–429, 1987.
  44. Omaye, S.T., J.H. Skala, M.D. Gretz, E.E. Schaus, and C.E. Wade. Simple method for bleeding the unanesthestized rat by tail venopuncture. Laboratory Animal 21:261–264, 1987.
  45. Jurney, T.H., J.L. Cockrell, J.S. Lindberg, J.M. Lamiell, J.P. Ducey, M.M. Hunt, and C.E. Wade. Adrenal insufficiency in intensive care unit patients. Chest 92:292–295, 1987.
  46. Heydorn, W.H., J.S. Daniel, and C.E. Wade. A new look at pericardial substitutes. Journal of Thoracic and Cardiovascular Surgery 94:291–296, 1987.
  47. Wade, C.E., S.R. Ramee, M.M. Hunt, and C.J. White. Hormonal and renal responses to converting enzyme inhibition during maximal exercise. J. Appl. Physiol. 63:1796–1800, 1987.
  48. Wade, C.E., I.M. Spitz, D.T. Krieger, P. Lahteenmaki, O. Heikinheimo, and C.W. Bardin. Effect of the antiglucocorticoid RU486 on adrenal function in dogs. J. Clin. Endo. Metab. 66:473–477, 1988.
  49. Wade, C.E., and J.P. Hannon. Confounding factors in the hemorrhage of conscious swine: a retrospective study of handling, splenectomy, and hyperthermia. Circ. Shock 24:175–182, 1988.
  50. White, C.J., S.R. Ramee, H.G. Card, L.A. Abrahams, C.E. Wade, and R. Virmani. Rapid production of atherosclerosis in miniature swine. Laser. Surg. Med. 8:318–321, 1988.
  51. Wade, C.E. What is the question? In: Sports Injury Research, F.R. Noyes and J.P. Albright, eds. Am. J. Sports Med. 16:538–542, 1988.
  52. Wade, C.E. What is the value of the case-control study? In: Sports Injury Research, F.R. Noyes and J.P. Albright, eds. Am. J. Sports Med. 16:553–554, 1988.
  53. Wade, C.E., P.P. Waring, D.S. Trail, V.L. Gildengorin, B.F. Williams, and G.D. Bonner. Effects of atropine, 2-PAM, or pyridostigmine in euvolemic and hemorrhagic conscious swine. Military Med. 153:470–476, 1988.
  54. Wade, C.E., J.S. Lindberg, J.L. Cockrell, J.M. Lamiell, M.M. Hunt, and T.H. Jurney. Upon admission adrenal steroidgenesis is adapted to the degree of illness in intensive care unit patients. J. Clin. Endo. Metab. 67:223–227, 1988.
  55. Freund B.J., C.E. Wade, and J.R. Claybaugh. Effects of exercise on atrial natriuretic factor: implications to fluid homeostatis. Sports Medicine 6:364–377, 1988.
  56. Rumisek, J.D., C.E. Wade, K. Kaplan, C.V. Okerberg, D. Corley, M.J. Barry, and J.S. Clarke. The influence of early surface thromboreactivity on long-term arterial graft patency. Surgery 105:654–661, 1989.
  57. Wade C.E., D.S. Trail, V.L. Gildengorin, and J.P. Hannon. Blood lactate as a prognosticator of survival following hemorrhage in conscious swine. Laboratory Animal Science 39:44–46, 1989.
  58. Greenleaf J.E., C.E. Wade, and G. Leftheriotis. Orthostatic responses following 30-day bed rest deconditioning with isotonic and isokinetic exercise training. Aviat. Space Environ. Med. 60:537–542, 1989.
  59. Bickell, W.H., S.P. Bruttig, and C.E. Wade. Hemodynamic responses to abdominal aortotomy in the anesthetized swine. Circ. Shock 28:321–332, 1989.
  60. Dubick, M.A., and C.E. Wade. Prekallikren and protease inhibitor levels in plasma from conscious, hemorrhaged and euvolemic swine infused with 7.5% NaCl/6% Dextran 70. Biochemical Archives 5:367–373, 1989.
  61. Wade C.E., J.P. Hannon, C.A. Bossone, M.M. Hunt, J.A. Loveday, R. Coppes, and V.L. Gildengorin. Resuscitation of conscious pigs following hemorrhage: comparative efficacy of small-volume resuscitation with normal saline, 7.5% NaCl, 6% Dextran, and 7.5% NaCl in 6% Dextran 70. Circ. Shock 29:193–204, 1989.
  62. Hannon J.P., C.E. Wade, C.E.A. Bossone, M.M.Hunt, and J.A. Loveday. Resuscitation of conscious pigs following hemorrhage: oxygen transport and demand before and after administration of 7.5% NaCl in 6% Dextran. Circ. Shock 29:205–217, 1989.
  63. Greenleaf J.E., E.M. Bernauer, A.C. Ertl, T.S. Trowbridge, and C.E. Wade. Work capacity during 30-day bed rest with isotonic and isokinetic exercise training. J. Appl Physiol. 67:1820–1826, 1989.
  64. Dubick, M.A., J.J. Summary, B.A. Ryan, and C.E. Wade. Dextran concentrations in plasma and urine following administration of 6% Dextran-70/7.5% NaCl to hemorrhaged and euvolemic conscious swine. Circ. Shock 29:301–310, 1989.
  65. Donatucci, C.F., G.E. Deshon, and C.E. Wade. Furosemide induced disturbances of renal function in patients undergoing TURP. Urology 35:295–300, 1990.
  66. Hannon, J.P., C.A. Bossone, and C.E. Wade. Normal physiological values for conscious pigs used in biomedical research. Lab. Anim. Sci. 40:293–298, 1990.
  67. Sondeen, J.L., G.A. Gonzaludo, J.A. Loveday, G.E. Deshon, C.B. Clifford, M.M. Hunt, W.G. Rodkey, and C.E. Wade. Renal responses to graded hemorrhage in conscious pigs. Am. J. Physiol. 259:R119–R129, 1990.
  68. Griffiths, R.B., R.H. Dressendorfer, C.D. Fullbright, and C.E. Wade. Testicular function during exhaustive endurance training. Physician Sports Medicine 18:54–64, 1990.
  69. Hannon, J.P., C.E. Wade, C.A. Bossone, M.M. Hunt, and J.A. Loveday. Resuscitation of conscious pigs following hemorrhage: blood gas and acid-base status during fixed volume hemorrhaged and resuscitation with hypertonic saline/dextran. Circ. Shock 32:19–29, 1990.
  70. Lindberg, J.S., J.B. Copley, K. Melton, C.E. Wade, J. Abrams, and D. Goode. Lysine vasopressin in the treatment of refractory hemodialysis-induced hypotension. Am. J. Nephrology. 10:269–275, 1990.
  71. Moore, G.L., J.J. Summary, M.A. Dubick, M.E. Ledford, B.A. Ryan, A. Gonzales, and C.E. Wade. The effects of hypertonic saline (7.5%)/Dextran-70 (HSD) on human red cell typing, lysis and metabolism in vitro. Vox Sanguinis. 59:227–231, 1990.
  72. Wade, C.E., J.P. Hannon, C.A. Bossone, and M.M. Hunt. A comparison of hypertonic saline/dextran and hypertonic saline over the first 30 minutes of resuscitation following hemorrhagic hypotension in conscious swine. Resuscitation 20:49–56, 1990.
  73. Yuan, X-Q., C.E. Wade, D.S. Prough, and D.S. DeWitt. Traumatic brain injury creates biphasic systemic hemodynamic and organ blood flow responses in rats. J. Neurotrauma 7:141–153, 1990.
  74. Sondeen, J.L., G.A. Gonzaludo, J.A. Loveday, W.G. Rodkey, and C.E. Wade. Hypertonic saline/dextran improves renal function after hemorrhage in conscious swine. Resuscitation 20:231–241, 1990.
  75. Dressendorfer, R.H., C.E. Wade, J.R. Claybaugh, S.A. Cucinell, and G.C. Timmis. Effects of 7 successive days of unaccustomed prolonged exercise on aerobic performance and tissue damage in fitness joggers. Int. J. Sports Med. 12:55–61, 1991.
  76. Dressendorfer, R.H., C.L. Keen, C.E. Wade, J.R. Claybaugh, and G.C. Timmis. Development of runner’s anemia during a 20-day road race: effect of iron supplements. Int. J. Sport Med. 12:332–336, 1991.
  77. Yuan, X-Q., C.E. Wade, and C.B. Clifford. Suppression by traumatic brain injury of spontaneous hemodynamic recovery from hemorrhagic shock in rats. J. Neurosurgery 75:408–414, 1991.
  78. Dressendorfer, R.H., and C.E. Wade. Effects of a 15-day race on plasma steroid levels and leg muscle fitness in runners. Med. Sci. Sports Exerc. 23:954–958, 1991.
  79. Wade, C.E., and J.P. Hannon. Modification of pituitary-adrenal axis to hemorrhage by handling techniques in conscious swine. Circ. Shock 34:379–384, 1991.
  80. Yuan, X-Q., C.E. Wade, and C.B. Clifford. Immediate hypertensive response to fluid percussion brain injury may be related to intracerebral hemorrhage and hypothalamic damage. J. Neurotrauma 8:219–228, 1991.
  81. Hess, J.R., C.E. Wade, and R.M. Winslow. Filtration-assisted exchange transfusion using aaHb, an erythrocyte substitute. J. Appl. Physiol. 70:1639–1644, 1991.
  82. Dubick, M.A., J.J. Summary, J.Y. Greene, and C.E. Wade. In vitro and in vivo effects of hypertonic saline/dextran-70 on protein determinations in serum or plasma (letter). Clinical Chemistry 37:1801–1802, 1991.
  83. Wade, C.E., J.P. Hannon, C.A. Bossone, M.M. Hunt, J.A. Loveday, R.I. Coppes, and V.L. Gildengorin. Neuroendocrine responses to hypertonic saline/dextran resuscitation following hemorrhage. Circ. Shock 35:37–43, 1991.
  84. Bickell, W.H., S.P. Bruttig, G.A. Millnamow, J. O’Benar, and C.E. Wade. The detrimental effects of intravenous cystalloid after aortotomy in swine. Surgery 110:529–536, 1991.
  85. Yuan, X-Q., and C.E. Wade. Neuroendocrine abnormalities in patients with traumatic brain injury. Frontiers in Neuroendocrinology 12:209–230, 1991.
  86. Yuan, X-Q., and C.E. Wade. The influences of traumatic brain injury on the outcomes of delayed and repeated hemorrhages. Circ. Shock 35:231–236, 1991.
  87. Hess, J.R., M.A. Dubick, J.J. Summary, N.R. Bangal, and C.E. Wade. The effects of 7.5% NaCl/6% Dextran 70 on coagulation and platelet aggregation in humans. J. Trauma 32:40–44, 1992.
  88. Dubick, M.A., B.A. Ryan, J.J. Summary, and C.E. Wade. Dextran metabolism following infusion of 7.5% NaCl/6% dextran-70 to envolemic and hemorrhaged rabbits. Drug Develop. Res. 25:29–38, 1992.
  89. Pascal, J.M.S., J.C. Watson, D.E. Runyon, C.E. Wade, and G.C. Kramer. Resuscitation of intraoperative hypovolemia: comparison of normal saline and hyperosmotic/hypertonic solutions in swine. Critical Care Med. 20:200–210, 1992.
  90. Wade, C.E., F.J. Tillman, J.A. Loveday, A. Blackman, E. Potanko, M.A. Hunt, and J.P. Hannon. Effect of dehydration on cardiovascular responses and electrolytes after hypertonic saline dextran treatment for moderate hemorrhage. Annals Emergency Med. 21:113–119, 1992.
  91. Dressendorfer, R.H., C.E. Wade, and E.C. Frederick. Effect of shoe cushioning on the development of reticulocytosis is distance runners. Am. J. Sports Med. 20:212–216, 1992.
  92. Summary, J.J., M.A. Dubick, G.M. Zaucha, A.F. Kilani, D.W. Korte, Jr., and C.E. Wade. Acute and subacute toxicity of 7.5% hypertonic saline/6% dextran (HSD) in dogs. Journal of Applied Toxicology 12:216–266, 1992.
  93. Greenleaf, J.E., J. Vernikos, C.E. Wade, and P.R. Barnes. Effects of leg exercise training on vascular volumes during 30 days of 6° head-down bed rest. J. Appl. Physiol. 72:1887–1894, 1992.
  94. Yuan, X-Q., and C.E. Wade. Traumatic brain injury attenuates the effectiveness of lactated ringer’s solution resuscitation of hemorrhagic shock in rats. Surg. Gynecology and Obstetics 174:305–312, 1992.
  95. Warton, W.W., J.L. Sondeen, M. McBiles, S.E. Gradwohl, C.E. Wade, D.P. Ciceri, H.G. Lehmann, R.E. Stotler, T.R. Henderson, W.R. Whitaker, and J.S. Lindberg. Measurement of glomerular filtration rate in ICU patinest using 99m TC- DTPA and insulin. Kidney Int. 42:174–178, 1992.
  96. Bickell, W.H., S.P. Bruttig, G.A. Millnamow, J. O’Benar, and C.E. Wade. Use of hypertonic saline/dextran versus lactated Ringer's solution as resuscitation fluid following uncontrolled aortic hemorrhage in anesthetized swine. Ann. Emerg. Med. 21:1077–1085, 1992.
  97. Spitz, I.M., O. Heikinheimo, and C.E. Wade. The divergent effect of RU486 on adrenal function in the dog is related to differences in its pharmacokinetics. Acta Endocrinologica 128:459–465, 1993.
  98. Gong, R., J. Lindberg, J. Abrams, W.R. Whitaker, C.E. Wade, and S. Gouge. Comparison of hypertonic saline solutions and dextran in dialysis-induced hypotension. Am. J. Nephrol. 3:1808–1812, 1993.
  99. Yuan, X-Q., and C.E. Wade. Lactated Ringer’s solution alleviates brain trauma precipitated lactic acidosis in hemorrhagic shock. J. Neurotrauma 10:307–313, 1993.
  100. Dubick, M.A., A.F. Kilani, J.J. Summary, J.Y. Greene, and C.E. Wade. Further evaluation of the effects of 7.5% sodium chloride/6% dextran -70 (HSD) administration on coagulation and platelet aggregation in hemorrhaged and euvolemic swine. Circ. Shock 40:200–205, 1993.
  101. Dubick, M.A., and C.E. Wade. A review of the efficacy and safety of 7.5% NaCl 6% dextran 70 in experimental animals and in humans. J. Trauma 36:323–330, 1994.
  102. Dubick, M.A., J. M. Davis, T. Myers, C.E. Wade, and G. C. Kramer. Dose response effects of hypertonic saline and dextran on cardiovascular responses and plasma volume expansion in sheep. Shock 3:2:137–144, 1995.
  103. Alexander, R.A., C.K. Lang, M.K. Steele, B.J. Corbin, M.F. Vasques, and C.E. Wade. Effects of chronic elevated levels of CO2 on the concentration of blood cellular elements and plasma corticosterone in the male rat. J Gravitational Physiol 2:P134–P135, 1995.
  104. Ho, H.S., J.L. Sondeen, M.A. Dubick, C.E. Wade, and R.A. Gunther. The renal effects of 7.5% NaCL-6% Dextran-70 versus lactated Ringer’s resuscitation of hemorrhage in dehydrated sheep. Shock 5:289–297, 1996.
  105. Wade, C.E., M.A. Dubick, M.J. Vassar, C.A. Perry, and J.W. Holcroft. Plasma dextra, sodium and potassium levels in trauma patients administered hypertonic saline-Dextran-70. Clinical Chemistry 42:779–780, 1996.
  106. Vernikos, J., D.A. Ludwig, A.C. Ertl, C.E. Wade, L.C. Keil, and D. O’Hara. Effect of standing or walking on physiological changes induced by head-down bed rest: implications for spaceflight. Aviat Space Environ Med 67:1069–1079, 1996.
  107. Wade, C.E., J.S. Harper, N.G. Daunton, M.L. Corcoran, and E. Morey-Holton. Body mass gain during altered gravity: spaceflight, centrifugation, and return to 1 G. J Gravitational Physiol 4:43–48, 1997.
  108. Wade, C.E., and R.M. Ortiz. Effects of habituated restraint on urinary cortisol levels in Rhesus monkeys. Contemporary Topics Lab Animal Sci. 5:55–57,1997.
  109. Wade, C.E., J.J. Grady, G.C. Kramer, R.N. Younes, K. Gehlsen, and J.W. Holcroft. Individual patient cohort analysis of the efficacy of HSD in patients with traumatic brain injury and hypotension. J Trauma 42:S1–S5, 1997.
  110. Wade, C.E., J.J. Grady, G.C. Kramer, R.N. Younes, T. Fabian, and J.W. Holcroft. Meta-analysis of the efficacy of HSD in patients with hypotension due to traumatic injury. Surgery 122:609–616, 1997.
  111. Kramer G.C., C.E. Wade and D.S. Prough Hypertonic Saline Dextran: efficacy and regulatory approval. Acta Anaesthesiol Scand 42:141–144, 1998.
  112. O’Benar J.D., Bruttig S.P., M.A. Dubick and C.E. Wade. Hemodynamic and metabolic responses to repeated hemorrhage and resuscitation with hypertonic saline dextran in conscious swine. Shock 10:223–228, 1998.
  113. Vasques M., C. Lang, R.E. Grindeland, R.R. Roy, N. Daunton, A.J. Bigbee and C.E. Wade. Comparison of hyper- and micro-gravity on rat muscle, organ weights and plasma chemistry. Aviation Space Environ. Med. 69:A2–A8, 1998.
  114. Wade C.E., and L.C. Keil. Reduction of pituitary AVP and OT contents in rats following spaceflight. Aviation Space Environ. Med. 69:A53–A57, 1998.
  115. Wade C.E., and E. Morey-Holton. Alteration of renal function of rats following spaceflight. American J Physiol: Reg Interg Comp Physiol 275:R1058–R1065, 1998.
  116. Moran M.M., R.R. Roy, C.E. Wade, B.J. Corbin and R.E. Grindeland. Size constraints of subcutaneous telemeters in rats. J Appl Physiol 85:1564–1571, 1998.
  117. Ortiz, R.M., T.J. Wang and C.E. Wade. Influence of centrifugation and hindlimb suspension on testosterone and corticosterone excretion in rats. Aviat Space Environ Med 70:499-504, 1999.
  118. Ortiz, R.M., T.J. Wang and C.E. Wade. Urea and osmotic excretion in rats exposed to chronic centrifugation. Aviation Space Environ. Med. 70:1089-1095, 1999.
  119. Convertino, V.A., S.C. Koenig, J.W. Fanton, C.A. Reister, F.A. Gaffney, D.A. Ludwig, D.L. Ewert, and C.E. Wade. Alteration in the volume stimulus-renal response relationship during exposure to simulated microgravity. J Gravitational Physiol 6:1-10, 1999.
  120. Wade C.E., L.A. Baer, W.A. Belisle, R.M. Ortiz and M.F. Vasques. Deposition and renal handling of urinary electrolytes from rats during spaceflight. J Gravitational Physiol 6:25-32, 1999.
  121. Wade, C.E. Hypertonic solutions in the care of patients undergoing surgery: an update. Problems in Anesthesiology 11:491-500, 1999.
  122. Grady, J., G. Kramer, C. Wade, J. Holcroft. Comparison of meta-analyses using summary data vs. individual patient data on trauma trials of hypertonic saline dextran. Proc. Am. Statistical Assoc. 1999.
  123. Wade, C.E. Hormonal regulation of fluid homeostasis during and following exercise. Contemporary Topics in Endocrinology Ed. M.P. Warren and N.W. Constantini Humana Press, Totowa, NJ pages 207-225, 2000.
  124. Wade, C.E., T.J. Wang, K.C. Lang, B.J. Corbin and M.K. Steele. Rat growth, body
    composition, and renal function during 30 days of increased ambient CO2. Aviation Space Environ. Med. 71:599-609, 2000.
  125. Wang, T.J. and C.E. Wade. Effects of hindlimb suspension and elevated ambient
    CO2 on rat growth and renal function. Aviation Space Environ. Med. 71:610-618, 2000.
  126. Brooke, D.P., P. Nambi, N. Laping, B. Olson, M. Pullen and C.E. Wade. Renal vasopressin receptor expression and function in rats following spaceflight. J Appl Physiol 88:1316-1320, 2000
  127. Wade, C.E. Hypertonic saline solutions for the initial treatment of patients with traumatic injuries. Transfusion Alternatives in Transfusion Medicine 173-184, 2000.
  128. Oritz, R.M., T.J. Wang and C.E. Wade. Water balance in rats exposed to chronic centrifugation. J Appl Physiol 89:56-60, 2000.
  129. Ortiz RM, C.E. Wade and C. L. Ortiz. Prolonged fasting increases the response of the renin-angiotensin-aldosterone system, but not vasopressin levels, in postweaned northern elephant seal pups. Gen Comp Endocrinol. 119:217-223, 2000.
  130. Ortiz, R., C.E. Wade, and E. Morey-Holton. Excreted LH and testosterone from rats during exposure to increased gravity: post-spaceflight and centrifugation. Proc. Soc. Exp Bio Med 225:98-102, 2000.
  131. Convertino, V.A., M.J. Luetkemeier, J.J. Elliott, D.A. Ludwig and C.E. Wade. Alterations in renal responsiveness to aldosterone during exposure to head-down tilt bedrest. J Appl Physiol 89:1737-1743, 2000.
  132. Wade C.E., L.A. Baer, and R.M. Ortiz Increases in body mass of rats during spaceflight: models and measurements. Aviation Space Environ. Med. 71:1126-1130, 2000.
  133. Baer L.A., A.E. Ronca, and C.E. Wade. Survival and growth of developing rodents during centrifugation at 2G. J Grav Physiol 7:17-22, 2000.
  134. Ortiz R.M., R.M. Patterson, C.E. Wade and F.M. Byers. Effects of acute fresh water exposure on water flux ratess and osmotic responses in Kemp’s Ridley sea turtles (Lepidochelys kempi). Comp. Biocem. Physiol. A Mol Integr Physiol. 127:81-87, 2000.
  135. Ronca, A.E., L.A. Baer, N.A. Mills, E.M. Sajdel-Sulkowska, and C.E. Wade. Body mass, food and water intake, and activity of pregnant and lactating rat dams during 1.5-g centrifugation. Journal of Gravitational Physiology, 7 (2), P131-P132, 2000.
  136. Ortiz R.M., C.E. Wade, and C.L. Ortiz. Effects of prolonged fasting on plasma cortisol and TH in postweaned northern elephant seal pups. Am J Physiol Regul Integr Comp Physiol. 280:R790-5, 2001.
  137. Moran M.M., T.P. Stein, and C.E. Wade Hormonal modulation of food intake inresponse to low leptin levels induced by hypergravity. Exp Biol Med. 226: 740-5, 2001.
  138. Stein T. P., and C. E. Wade. The catecholamine response to space flight: role of diet and gender. Am J Physiol Endocrinol Metab. 281:E500-6, 2001.
  139. Sajdel-Sulkowska E. M. Ronca, A.E., L.A. Baer, G. M. Sulkowska, N. Koibuch and C.E. Wade. The effect of hypergravity on cerebellar development may be mediated by altered thyroid status. Exp Biol Med. 226:790-798, 2001.
  140. Ronca, A.E., L.A. Baer, N. G. Daunton and C.E. Wade. Maternal reproductive experience enhances early postnatal outcome following gestation and birth of rats in hypergravity. Bio. Reproduction 65: 805-13, 2001.
  141. Ludwig D. A., J. Vernikos, C.E. Wade and V.A. Convertino. A. Blood pressure changes during orthostatic stress: evidence of gender differences in neuroeffector distribution. Aviat Space Environ Med. 72:892-898, 2001.
  142. Convertino VA, D.A. Ludwig, J.J. Elliott JJ, and C.E. Wade. Evidence for central venous pressure resetting during initial exposure to microgravity. Am J Physiol Regul Integr Comp Physiol 281:R2021-8, 2001.
  143. Roy R. R., A. Ishihara, Ph.D., M. M. Moran, C. E. Wade and V.R. Edgerton. No effect of 2 weeks of hypergravity on rat ventral horn neuron size or SDH activity. Aviat Space Environ Med. 72:1107-1112, 2001.
  144. Convertino V.A., D.A. Ludwig, J.J. Elliott JJ, and C.E. Wade. Is there resetting of centeral venous pressure in microgravity? Journal of Gravitational Physiology 8:P51-P52, 2001.
  145. Wang T.J. and C. E. Wade. Renal function of rats in response to 37 days of head-down tilt. J Grav Physiol 8:85-9, 2001.
  146. Ortiz R.M., C.E. Wade, D.P. Costa and C.L. Ortiz. Renal responses to plasma volume expansion and hyperosmolality in fasting seal pups. Am J Physiol Regul Integr Comp Physiol. 282:R805-17, 2002.
  147. White, L.J., R.H. Dressendorfer, M.A. Ferguson, and C.E. Wade. Maintenance of testosterone status in fitness joggers after increased training mileage. Eur. J. Appl. Physiol. 86:498-502, 2002.
  148. Ortiz R.M., C.E. Wade, D.P. Costa and C.L. Ortiz. Renal effects of freah water-induced hypo-osmolality in marine adapted seals. J. Comp. Physiol. B 172:297-307, 2002.
  149. Narayan, R.K., MD, M.E. Michel, and The Clinical Trials in Head Injury Study Group*. (Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, Bullock MR, Choi SC, Clifton GL, Contant CF, Coplin WM, Dietrich WD, Ghajar J, Grady SM, Grossman RG, Hall ED, Heetderks W, Hovda DA, Jallo J, Katz RL, Knoller N, Kochanek PM, Maas AI, Majde J, Marion DW, Marmarou A, Marshall LF, McIntosh TK, Miller E, Mohberg N, Muizelaar JP, Pitts LH, Quinn P, Riesenfeld G, Robertson CS, Strauss KI, Teasdale G, Temkin N, Tuma R, Wade C, Walker MD, Weinrich M, Whyte J, Wilberger J, Young AB, Yurkewicz L.) Clinical trials in head injury. J. Neurotrauma 19:503-57, 2002.
  150. Stein T.P., M.D. Schluter, A.T Galante, P. Soteropoulos, P.P. Tolias, R.E. Grindeland, M.M. Moran, T.J. Wang, M. Polansky, C.E. Wade. Energy metabolism pathways in rat muscle under conditions of simulated gravity. J Nutritional Biochem. 13:471-478, 2002.
  151. Wade C.E., M. M. Moran, and J. Oyama Resting energy expenditure of rats acclimated to hyper-gravity. Aviat Space Environ Med. 73:859-864,2002.
  152. Tou J.C.L. and C.E. Wade. Determinants affecting physical activity level. Exp Biol Med. 227:587-600, 2002.
  153. Wade C.E., M.M. Miller, L.A. Baer, M.M. Moran, M.K. Steele, and T.P. Stein. Body mass, energy intake and water consumption of rats and humans during spaceflight. Nutrition 18:829-36, 2002.
  154. Tou J., A. Ronca , R. Grindeland and C. Wade. Models to study gravitational biology of mammalian reproduction. Biol Reprod. 67:1681-7, 2002.
  155. Stein T.P., M.D. Schluter, R.E. Grindeland, M.M. Moran, T.J. Wang, M. Polansky, and C.E. Wade. Rate controlling steps in fatty acid oxidation by unloading rodent soleus muscle. J Gravitational Physiol, 9:P165-P166, 2002
  156. Ronca, A.E., L.A.Baer and C.E. Wade. Hypergravity effects on pregnancy and parturition. J Gravitational Physiol, 9:P203-P204, 2002.
  157. Baer, L.A., C.E. Wade and A.E. Ronca. Effects of hypergravity exposure on plasma oxytocin concentrations in pregnant and lactating rat dams. J Gravitational Physiol, 9:P205-P206, 2002.
  158. Wade C. E. Hypertonic saline resuscitation in sepsis. Critical Care 6:397-8, 2002.
  159. Stein T.P., and C.E. Wade. Protein turnover in atrophying muscle: from nutritional intervention to microarray expression analysis. Curr Opin Clin Nutr Metab Care. 6:95-102, 2003.
  160. Ortiz R.M., C.E. Wade, D.P. Costa and C.L. Ortiz. Renal water handling in response to hypertonic-saline induced diuresis in fasting northern elephant seal pups (Mirounga angustirostris). J. Comp. Physiol. A 134:423-428, 2003.
  161. Ortiz R.M., D.S. Houser, C.E. Wade and L.C. Ortiz. Hormonal changes associatedwith the transition between nursing and natural fasting in northern elephant seals (Mirounga angustirostris). Gen Comp Endocrinol. 130:78-83, 2003.
  162. Ortiz, R.M., C.E. Wade, L. Ortiz and F. Talamantes. Acutely elevated vasopressin increases circulating levels of cortisol and aldosterone in fasting northern elephant seal (Mirounga angustirostris) pups. J. Exp. Biol. 206: 2795-802, 2003.
  163. Wade CE, Grady JJ, Kramer GC. Efficacy of hypertonic saline dextran fluid resuscitation for patients with hypotension from penetrating trauma. J Trauma. 54:S144-S148, 2003.
  164. Holley D.C., C.W. DeRoshia, M.M. Moran and C. E. Wade. Chronic centrifugation
    (hypergravity) disrupts the circadian system of the rat. J Appl Physiol. 95:1266-1278, 2003.
  165. Tou, J., R. Grindeland, J. Barrett, B. Dalton, A. Mandel and C. Wade. Evaluation of NASA foodbars as a standard diet for use in short-term rodent space flight studies. Nutrition 19: 947-954, 2003.
  166. Ronca, A.E., Wade, C.E. and Plaut, K. The remarkable linearity between gravity and mammary metabolism. Comments on Theoretical Biology, 8:627-641,2003.
  167. Plaut, K., R.L. Maple, C.E. Wade, L.A. Baer, and A.E Ronca,. Effects of hypergravity on mammary metabolic function: Gravity acts as a continuum. J. Appl. Physio. 95: 2350-2354, 2003.
  168. Hilder T.L., J.C.L. Tou, R.E. Grindeland , C.E. Wade, and L. M. Graves. Phosphorylation of insulin receptor substrate-1 serine 307 correlates with JNK activity in atrophic skeletal muscle. FEBS Letters 553: 63-67, 2003.
  169. Wade, C.E., M.A. Dubick and J.J. Grady. Optimal dose of hypertonic saline dextran (HSD) in hemorrhaged swine. J. Trauma 55: 413-416, 2003.
  170. Baer LA, J.H. Chowdhury, R.E. Grindeland, C.E. Wade, A.E. Ronca. Effects of hypergravity rearing on Growth Hormone and Insulin-Like Growth Factor in rat pups. J Grav Phys, 10(1):P67-P68, 2003.
  171. Ronca AE, L.A. Baer, C.E. Wade. Intrauterine pressure (IUP) telemetry in pregnant and parturient rats: Potential application for spaceflight and centrifugation studies. J Grav Phys, 10(1):P113-P114, 2003.
  172. Dubick, M.E. and C.E. Wade. Evaluation of the local irritation potential of hypertonic saline/dextran (HSD) in mice and rabbits. Journal of Applied Toxicology 24:409-413, 2004.
  173. Tou J.C., R.E. Grindeland and C.E. Wade. Effects of diet and exposure to hindlimb
    suspension on estrous cycling in Sprague-Dawley rats. Am J Physiol Endocrinol Metab. 286(3):E425-33, 2004.
  174. Kramer, G.C., C.E. Wade, M.A. Dubick, and J.L. Atkins. Strategies for small volume resuscitation hyperosmotic-hyperoncotic solutions, hemoglobin basedoxygen carriers and closed-loop resuscitation. In: RTO-MP-HFM-109 Combat Casualty Care in Ground-Based Tactical Situations: Trauma Technology and Emergency Medical Procedures, 7-1 to 7-36, www.rta.nato.int/Reports.asp, 2004.
  175. Stein T.P., M.D. Schluter, A.T. Galante, P. Soteropoulos, M. Ramirez, A. Bigbee, R.E. Grindeland and C.E. Wade. Effect of hind limb muscle unloading on liver metabolism of rats. J. Nutritional Biochem. 16:9-16, 2005.
  176. Iwaniec U.T., T.J. Wronski, D. Amblard, Y. Nishimura, M.C.H. van der Meulen, C.E. Wade, M.A. Bourgeois, C.D. Damsky, and R.K. Globus. Effects of disrupted 1 integrin function on the skeletal response to short-term unloading in mice. J Appl Physiol. 98:690-6, 2005.
  177. Wade C.E., K.I. Stanford, T.P. Stein and J.E. Greenleaf. Intensive exercise training suppresses testosterone during bed rest . J Appl Physiol Feb 2005.
  178. Stein T.P. and C.E. Wade. Metabolic consequences muscle disuse. J. Nutrition 135(7):1824S-8S, 2005.
  179. Tou J.C.L., S.B. Arnaud, R.E. Grindeland, and C.E. Wade. The Effect of Purified AIN-93G Versus a Standard non-purified diet on bone changes induced by hindlimb suspension of female rats. Exp Biol Med. 230:31-9, 2005.
  180. Bruttig S.P., J.D. O'Benar, C.E. Wade and M.A. Dubick. Benefit of Slow Infusion of Hypertonic saline/dextran (HSD) in swine with uncontrolled aortotomy hemorrhage. Shock 24(1):92-96, 2005.
  181. Wade C.E. and J.B. Holcomb. Endpoints in clinical trials involving patients with traumatic injuries. Transfusion 45 Suppl 1:4S-8S, 2005.
  182. Zakrzewska EI, Maple R, Lintault L, Wade C, Baer L, Ronca A, Plaut K. Association between gravitational force and tissue metabolism in periparturient rats. J Gravit Physiol. 11(2):P157-60, 2004.
  183. Kauvar D.S., C.E. Wade and H.J. Oestern. The epidemiology and modern management of traumatic hemorrhage. Cri Care Med 9 Suppl 5:S1-9, 2005.
  184. Wade CE, Stanford KL, Stein TP, Greenleaf JE. Intensive Exercise Training Suppresses Testosterone During Bed Rest. J Appl Physiol 99(1):59-63, Feb 2005.
  185. Wade CE, Holcomb JB. Endpoints in Clinical Trials of Fluid Resuscitation of Patients With Traumatic Injuries. Transfusion 45 Suppl:4S-8S, Jul 2005.
  186. Wade CE. Responses across the gravity continuum: hypergravity to microgravity. Adv Space Biol Med. 10:225-4, Aug 2005.
  187. Hilder TL, Baer LA, Fuller CA, Grindeland RE, Wade CE, Graves LM. Insulin-Independent Pathways Mediating Glucose Uptake in Hindlimb Suspended Skeletal Muscle. J Appl Physiol. 99(6):2181-8, Aug 2005.
  188. Baer LA, Rushing LS, Wade CE, Ronca AE. Prenatal centrifugation: a model for fetal programing of body weight? J Grav Physiol 12:P18-P182, 2005.
  189. Ronca AE, Rushing LS, Tou J, Wade CE, Baer LA. Centrifugation effects on estrous cycling, mating success and pregnancy outcome in rats. J Grav Physiol 12:P183-P184, 2005.
  190. Holcomb JB, Stansbury LG, Champion HR, Wade CE, Bellamy RF. Understanding Combat Casualty Care Statistics. J Trauma. 60(2):397-401, Feb 2006.
  191. Pusateri AE, Holcomb JB, Kheirabadi BS, Alam HB, Wade CE, Ryan KL. Making sense of the preclinical literature on advanced hemostatic products. J Trauma 60(3):674-82, Mar 2006.
  192. Dishman RK, Berthoud HR, Booth FW, Cotman CW, Edgerton VR, Fleshner MR, Gandevia SC, Gomez-Pinilla F, Greenwood BN, Hillman CH, Kramer AF, Levin BE, Moran TH, Russo-Neustadt AA, Salamone JD, Van Hoomissen JD, Wade CE, York DA, Zigmond MJ. Neurobiology of exercise. Obesity (Silver Spring) 14(3):345-56, Mar 2006.
  193. Dubick MA, Bruttig SP, Wade CE. Issues of concern regarding the use of hypertonic/hyperoncotic fluid resuscitation of hemorrhagic hypotension. Shock 25(4):321-328, Apr 2006.
  194. McHenry TP, Mirza SK, Wang J, Wade CE, O’Keefe GE, Dailey AT, Schreiber MA, Chapman JR. Risk factors for respiratory failure following operative stabilization of thoracic and lumbar spine fractures. J Bone Joint Surg Am 88(5):997-1005, May 2006.
  195. Kauvar DS, Cancio LC, Wolf SE, Wade CE, Holcomb JB. Comparison of combat and non-combat burns from ongoing U.S. military operations. J Surg Res 132(2):195-200, May 2006.
  196. Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma 2006 Jun; 60(6 Suppl):S3-S11.
  197. Wolf SE, Kauvar DS, Wade CE, Cancio LC, Renz EP, Horvath EE, White CE, Park MS, Wanek S, Albrecht MA, Blackbourne LH, Barillo DJ, Holcomb JB. Comparison between civilian burns and combat burns from Operation Iraqi Freedom and Operation Enduring Freedom. Ann Surg 2006 Jun; 243(6):786-92; discussion 792-5.
  198. Kauvar DS, Wolf SE, Wade CE, Cancio LC, Renz EM, Holcomb JB. Burns sustained in combat explosions in Operations Iraqi and Enduring Freedom (OIF/OEF explosion burns). Burns 2006 Nov; 32(7):853-7.
  199. Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR. Damage control resuscitation:directly addressing the early coagulopathy of trauma. J Trauma 2007 Feb; 62(2):307-10.
  200. Lintault LM, Zakrzewska EI, Maple RL, Baer LA, Casey TM, Ronca AE, Wade CE, Plaut KI. In a hypergravity environment neonatal survival is adversely affected by alterations in dam tissue metabolism rather than reduced food intake. J App Physiol 102(6):2186-93, Jun 2007.
  201. Eastridge B, Salinas J, Baskin T, McManus J, Wade CE, Holcomb JB. Trend in shock index after injury predicts complications, life saving interventions, and mortality. Acad Emerg Med 14(5 Suppl 1):S138. (abst), May 2007.
  202. Perkins JG, Schreiber MA, Wade CE, Holcomb JB. Early versus late recombinant factor VIIa in combat trauma patients requiring massive transfusion. J Trauma 62(5):1095-1101, May 2007.
  203. Holcomb JB, McMullin NR, Pearse L, Caruso J, Wade CE, Oetjen-Gerdes L, Champion HR, Lawnick M, Farr W, Rodriguez S, Butler FK. Causes of death in U.S. Special Operations Forces in the Global War on Terrorism: 2001-2004. Ann Surg 245(6):986-991, Jun 2007.
  204. Horvath EE, Murray CK, Vaughan GM, Chung KK, Hospenthal DR, Wade CE, Holcomb JB, Wolf SE, Mason AD Jr, Cancio LC. Fungal wound infection (not colonization) is independently associated with mortality in burn patients. Ann Surg 245(6):978-985, Jun 2007.
  205. Martini WZ, Dubick MA, Wade CE, Holcomb JB. Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs. Crit Care Med 35(6):1568-78, Jun 2007.
  206. McManus JG, Eastridge BJ, Wade CE, Holcomb JB. Hemorrhage control research on today’s battlefield: lessons applied. J Trauma 62(6 Suppl):S14. Review, Jun 2007.
  207. Patel OV, Maple RL, Baer LA, Wade CE, Plaut K. Tissue-specific variation in hypergravity-exposed rats. J Gravit Physiol 14(1):P129-30, Jul 2007.
  208. Eastridge BJ, Salinas J, McManus JG, Blackbourne LH, Bugler EM, Cooke WH, Convertino VA, Wade CE, Holcomb JB. Hypotension begins at 110 mm Hg: redefining “hypotension” with data. J Trauma 63(2):291-7; discussion 297-9, Aug 2007.
  209. Pidcoke HF, Wade CE, Wolf SE. Insulin and the burned patient. Crit Care Med 35(9Suppl)S524-30, Sep 2007.
  210. Sondeen JL, Dubick MA, Holcomb JB, Wade CE. Uncontrolled hemorrhage differs from volume- or pressure-matched controlled hemorrhage in swine. Shock 28(4):426-33, Oct 2007.
  211. Schreiber MA, Perkins J, Kiraly L, Underwood S, Wade CE, Holcomb JB. Early predictors of massive transfusion in combat casualties. J Am Coll Surg 205(4):541-545, Oct 2007.
  212. Mann EA, Pidcoke HF, Salinas J, Wade CE, Holcomb JB, Wolf SE, Lacara T, Domagtoy C, Lickliter D, Quattrocchi K, Snipes L, Kuszaj J, Prasnikar M. Accuracy of glucometers should not be assumed. Am J Crit Care 16(6):531-532, Nov 2007.
  213. Pidcoke HF, Salinas J, Wanek SM, Concannon M, Loo F, Wirfel KL, Holcomb JB, Wolf SE, Wade CE. Patterns of exogenous insulin requirement reflect insulin sensitivity changes in trauma. Am J Surg 194(6):798-803, Dec 2007.
  214. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 63(4):805-13, Oct 2007.
  215. Mann EA, Salinas J, Pidcoke HF, Wolf SE, Holcomb JB, Wade CE. Error rates resulting from anemia can be corrected in multiple commonly used point-of-care glucometers. J Trauma 64(1):15-20; discussion 20-1, Jan 2008.
  216. Delgado AV, Kheirabadi BS, Fruchterman TM, Scherer M, Cortez D, Wade CE, Dubick MA, Holcomb JB. A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic Swine with grade V liver injury. J Trauma 64(1):75-80, Jan 2008.
  217. Kelly JF, Ritenour AE, McLaughlin DF, Bagg KA, Apodaca AN, Mallak CT, Pearse L, Lawnick MM, Champion HR, Wade CE, Holcomb JB. Injury severity and causes of death from Operation Iraqi Freedom and Operation Enduring Freedom. J Trauma 64(2 Suppl):S21-27, Feb 2008.
  218. Kragh JF, Walters TJ, Baer DG, Fox CJ, Wade CE, Salinas J, Holcomb JB. Practical use of emergency tourniquets to stop bleeding in major limb trauma. J Trauma 64(2 Suppl):S38-50, Feb 2008.
  219. Cancio LC, Wade CE, West SA, Holcomb JB. Prediction of mortality and of the need for massive transfusion in casualties arriving at combat support hospitals in Iraq. J Trauma 64(2 Suppl):S51-56, Feb 2008.
  220. McLaughlin DF, Niles SE, Salinas J, Perkins JG, Cox DE, Wade CE, Holcomb JB. A predictive model for massive transfusion in combat casualty patients. J Trauma 64(2 Suppl): S57-63, Feb 2008.
  221. Plotkin AJ, Wade CE, Jenkins DH, Smith IKA, Noe JC, Park MS, Perkins JG, Holcomb JB. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma 64(2 Suppl): S64-68, Feb 2008.
  222. Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Niles SE, McLaughlin DF, Wade CE, Holcomb JB. Effect of plasma and red blood cell transfusions on survival in patients with combat related traumatic injuries. J Trauma 64(2 Suppl) S69-78, Feb 2008.
  223. Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an Army combat support hospital. J Trauma 64(2 Suppl):S79-85, Feb 2008.
  224. Ennis JL, Chung KK, Renz EM, Barillo DJ, Albrecht MC, Jones JA, Blackbourne, LH, Cancio LC, Eastridge BJ, Flaherty SF, Dorlac WC, Kelleher KS, Wade CE, Jenkins DH, Holcomb JB. Joint Theater Trauma System implementation of burn resuscitation guidelines improves outcomes in severely burned military casualties. J Trauma 64(2 Suppl): S146-152, Feb 2008.
  225. Ritenour AE, Dorlac WC, Fang R, Woods T, Jenkins DH, Flaherty SF, Wade CE, Holcomb JB. Complications after fasciotomy revision and delayed compartment release in combat patients. J Trauma 64(2 Supp.): S153-162, Feb 2008.
  226. Ritenour AE, Wickley A, Ritenour JS, Kriete BR, Blackbourne LH, Holcomb JB, Wade CE. Tympanic membrane perforation and hearing loss from blast overpressure in Operation Enduring Freedom and Operation Iraqi Freedom wounded. J Trauma 64(2 Suppl): S174-179, Feb 2008.
  227. Chung KK, Juncos LA, Wolf SE, Mann EE, Renz EM, White CE, Barillo DJ, Clark RA, Jones JA, Edgecombe HP, Park MS, Albrecht MC, Cancio LC, Wade CE, Holcomb JB. Continuous renal replacement therapy improves survival in severely burned military casualties with acute kidney injury. J Trauma 64(2 Supp.): S179-187, Feb 2008.
  228. Park MS, Salinas J, Wade CE, Wang J, Martini MZ, Pusateri AE, Merrill GA, Chung KK, Wolf SE, Holcomb JB. Combining early coagulation and inflammatory status improves prediction of mortality in burned and nonburned trauma patients. J Trauma 64(2 Suppl): S188-194, Feb 2008.
  229. Owens BD, Kragh JF Jr, Wenke JC, Macaitis J, Wade CE, Holcomb JB. Combat wounds in operation Iraqi Freedom and operation Enduring Freedom. J Trauma 64(2):295-9, Feb 2008.
  230. Spinella PC, Perkins JG, McLaughlin DF, Niles SE, Grathwohl KW, Beekley AC, Salinas J, Mehta S, Wade CE, Holcomb JB. The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion. J Trauma 64(2):286-93; discussion 293-4, Feb 2008.
  231. Radek KA, Baer LA, Eckhardt J, Dipietro LA, Wade CE. Mechanical unloading impairs keratinocyte migration and angiogenesis during cutaneous wound healing. J Appl Physiol, Feb 2008.
  232. Batchinsky AL, Wolf SE, Molter N, Kuusela T, Jones JA, Moraru C, Boehme M, Williams K, Bielke P, Wade CE, Holcomb JB, Cancio LC. Assessment of cardiovascular regulation after burns by nonlinear analysis of the electrocardiogram. J Burn Care Res 29(1):56-63, Jan/Feb 2008.
  233. Tou JC, Foley A, Yuan YV, Arnaud S, Wade CE, Brown M. The effect of ovariectomy combined with hindlimb unloading and reloading on the long bones of mature Sprague-Dawley rats. Menopause 15(3):[E pub], Jan 2008
  234. Salinas J, Drew G, Gallagher J, Cancio LC, Wolf SE, Wade CE, Holcomb JB, Herndon DN, Kramer GC. Closed-loop and decision-assist resuscitation of burn patients. J Trauma 64(4 Suppl):S321-32. Review, Apr 2008.
  235. Niles SE, McLaughlin DF, Perkins JG, Wade CE, Li Y, Spinella PC, Holcomb JB. Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma 64(6):1459-63; discussion 1463-5, Jun 2008.
  236. Grathwohl KW, Black IH, Spinella PC, Sweeney J, Robalino J, Helminiak J, Grimes J, Gullick R, Wade CE. Total intravenous anesthesia including ketamine versus volatile gas anesthesia for combat-related operative traumatic brain injury. Anesthesiology 109(1):44-53, Jul 2008.
  237. Patel OV, Zakrzewska E, Maple RL, Baer LA, Ronca AE, Wade CE, Plaut K. Lipogenesis impaired in periparturient rats exposed to altered gravity is independent of prolactin and glucocorticoid secretion. Eur J Appl Physiol, Jul 2008.
  238. Murray CK, Loo FL, Hospenthal DR, Cancio LC, Jones JA, Kim SH, Holcomb JB, Wade CE, Wolf SE. Incidence of systemic fungal infection and related mortality following severe burns. Burns, Aug 2008.
  239. Mann E, Pidcoke HF, Salinas J, Holcomb JB, Wolf SE, Wade CE. The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers. J Burn Care Res, Aug 2008.
  240. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 248(3):447-58, Sep 2008.
  241. Cancio LC, Batchinsky AI, Salinas J, Kuusela T, Convertino VA, Wade CE, Holcomb JB. Heart-rate complexity for prediction of prehospital lifesaving interventions in trauma patients. J Trauma 65(4):813-9, Oct 2008.
  242. Wade CE. Hyperglycemia may alter cytokine production and phagocytosis by means other than hyperosmotic stress. Crit Care 12(5):182, Oct 2008.
  243. Eastridge BJ, Blackbourne L, Wade CE, Holcomb JB. Radiologic diagnosis of explosion casualties. American J of Disaster Medicine 3(5):301-5, Sep/Oct 2008.
  244. Kragh JF Jr, Walters TJ, Baer DG, Fox CJ, Wade CE, Salinas J, Holcomb JB. Survival with emergency tourniquet use to stop bleeding in major limb trauma. Ann Surg 249(1):1-7, 2009.
  245. Wolf SE, Shields BA, Wade CE. Substrate utilization in the critically ill. JPEN J Parenter Enteral Nutr Jan-Feb 33(1):111; author reply 112, 2009.
  246. Mann EA, Pidcoke HF, Salinas J, Wolf SE, Wade CE, Holcomb JB. Hematocrit causes the most significant error in point of care glucometers. Crit Care Med Apr 37(4):1530, 2009; author reply 1530-1.
  247. Gomez R, Murray CK, Hospenthal DR, Cancio LC, Renz EM, Holcomb JB, Wade CE, Wolf SE. Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit. J Am Coll Surg Mar 208(3):348-54, 2009.
  248. Wade CE, Dubick MA, Blackbourne LH, Holcomb JB. It is time to assess the utility of thrombelastography in the administration of blood products to the patient with traumatic injuries. J Trauma Apr 66(4):1258, 2009.
  249. Thomas R, McManus JG, Johnson A, Mayer P, Wade CE, Holcomb JB. Ocular reduction from ocular protection use in current combat operations. J Trauma 2009 Apr, 66(4 Suppl): S99-103.
  250. Murray CK, Loo FL, Hospenthal DR, Cancio LC, Jones JA, Kim SH, Holcomb JB, Wade CE, Wolf SE. Incidence of systemic fungal infection and related mortality following severe burns. Burns 2008 Dec; 34(8):1108-12.
  251. Mora AG, Ritenour AE, Wade CE, Holcomb JB, Blackbourne LH, Gaylord KM. Posttraumatic stress disorder in combat casualties with burns sustaining primary blast and concussive injuries. J Trauma Apr; 66(4 Suppl):S178-85, 2009.
  252. Perkins JG, Andrew CP, Spinella PC, Blackbourne LH, Grathwohl KW, Repine TB, Ketchum L, Waterman P, Lee RE, Beekley AC, Sebesta JA, Shorr AF, Wade CE, Holcomb JB. An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients. J trauma Apr; 66(4 Suppl):S77-84; discussion S84-5, 2009.
  253. Thomas R, McManus JG, Johnson A, Mayer P, Wade CE, Holcomb JB. Ocular injury reduction from ocular protection use in current combat operations. J Trauma. 2009 Apr;66(4 Suppl):S99-103.
  254. Trudel G, Payne M, Mädler B, Ramachandran N, Lecompte M, Wade C, Biolo G, Blanc S, Hughson R, Bear L, Uhthoff HK. Bone Marrow Fat Accumulation after 60 Days of Bedrest Persisted 1 Year after Resuming Activities Along with Hemopoietic Stimulation - the WISE Study. J Appl Physiol. 2009 Aug; 107(2):540-8.
  255. Ritenour AE, Christy RJ, Roe JL, Baer DG, Dubick MA, Wade CE, Holcomb JB, Walters TJ. The effect of a hypobaric, hypoxic environment on acute skeletal muscle edema after ischemia-reperfusion injury in rats. J Surg Res, May 3, 2009 [Epub ahead of print]
  256. Kragh JF Jr, Littrel ML, Jones JA, Walters TJ, Baer DG, Wade CE, Holcomb JB. Battle casualty survival with emergency tourniquet use to stop limb bleeding. J Emerg Med 2009 Aug 28. [Epub ahead of print]
  257. Pidcoke HF, Wade CE, Mann EA, Salinas J, Cohee BM, Holcomb JB, Wolf SE. Anemia causes hypoglycemia in intensive care unit patients due to error in single-channel glucometers: Methods of reducing patient risk. Crit Care Med 2009 Sep [Epub ahead of print}
  258. Spinella PC, Carroll CL, Staff I, Gross R, McQuay J, Keibel L, Wade CE, Holcomb JB. Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in-hospital mortality in patients with traumatic injuries. Crit Care 2009 Sep 13(5):R151.
  259. Kauvar DS, Wade CE, Baer DG. Burn hazards of the deployed environment in wartime epidemiology of noncombat burns from ongoing United States military operations. J Am Coll Surg 2009 Oct 209(4):453-60.
  260. Pidcoke HF, Wanek SM, Rohleder LS, Holcomb JB, Wolf SE, Wade CE. Glucose variability is associated with high mortality after severe burn. J Trauma 2009 Nov 67(5):990-5.
  261. Mann ME, Mora AG, Pidcoke HF, Wolf SE, Wade CE. Glycemic control in the burn intensive care unit: Focus on the role of anemia in Glucose measurement. J Diabetes Sci Technol 2009 Nov 3(6):1319-29.
  262. Wade CE. Prior exercise alters responses to hemorrhage. Shock 2009 Dec 7 [Epub ahead of print}
  263. McLaughlin DF, Wade CE, Champion HR, Salinas J, Holcomb JB. Thromboembolic complications following trauma. Transfusion 2009 Dec, 49 Suppl 5:256S-63S.
  264. Cox ED, Schreiber MA, McManus J, Wade CE, Holcomb JB. New hemostatic agents in the combat setting. Transfusion 2009 Dec, 49 Suppl 5:248S-55S.
  265. Eastridge BJ, Costanzo G, Jenkins D, Spott MA, Wade C, Greydanus D, Flaherty S, Rappold J, Dunne J, Holcomb JB, Blackbourne CH. Impact of joint theater trauma system initiatives in battlefield injury outcome. Am J Surg 2009 Dec, 198(6):852-7.
  266. D’Avignon LC, Hogan BK, Murray CK, Loo FL, Hospenthal DR, Cancio LC, Kim SH, Renz EM, Barillo D, Holcomb JB, Wade CE, Wolf SE. Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: An autopsy series. Burns 2010 Jan [Epub ahead of print]
  267. Levy JH, Dutton RP, Hemphill JC, Shander A, Cooper D, Paidas MJ, Kessler CM, Holcomb JB, Lawson jH, Hemostasis Summit Participants. Multidisciplinary approach to the challenge of hemostasis. Anesth Analg 2010 Feb, 110(2):354-64.

Contact Information

Charles E. Wade, Ph.D.
  • Charles E. Wade, PhD

  • Professor of Surgery
    Division of Acute Care Surgery
    The University of Texas Medical School at Houston

  • Department of Surgery

  • 6431 Fannin Street
    MSB 5.204
    Houston, Texas 77030

  • phone: (713) 500-5391
    e-mail: Charles.E.Wade
    @uth.tmc.edu

Sr. Staff Assistant:
C. Renee Klaevemann