The Department of Pediatric Surgery at the University of Texas Medical School at Houston
Department of Pediatrics
The Department of Pediatric Surgery

Faculty Biography

The Division of General and Thoracic Pediatric Surgery 


Charles Cox Jr, MD

Dr. Cox is the Children's Fund Distinguished Professor and Director of the Pediatric Trauma Program at Children's Memorial Hermann Hospital with a special interest in the operative and non-operative management of traumatically injured infants and children. He is the Co-director of the Extra-Corporeal Life Support Program (ECMO). He completed his Pediatric Surgery Training at the University of Michigan and is board certified in Surgery, Critical Care and Pediatric Surgery, with a special interest in diseases of the intestines, colon and rectum. He joined the University in 1996.

Back

EDUCATION

Undergraduate Education

1980-1984 University of Texas at Austin BA

Graduate Education

1984-1988 The University of Texas Medical Branch at Galveston MD

Postgraduate Training

Internship in Surgery:
1988-1989 University of Texas Health Science Center at Houston
Residency in Surgery:
1989-1990
1992-1993
1993-1994 University of Texas Health Science Center at Houston
University of Texas Health Science Center at Houston
University of Texas Health Science Center at Houston

Fellowships:

1990-1992 NIH Research Fellow in Trauma and Burns
Shriner’s Burns Institute, University of Texas Medical Branch
1994-1996 Pediatric Surgery, University of Michigan
1996-1997 Surgical Critical Care, University of Texas-Houston

MILITARY

1990 to 1996 Captain, Medical Corps United States Army Reserve
1996 to 2002 Major, Medical Corps United States Army Reserve
2002 to 2004 Lieutenant Colonel, Medical Corps United States Army Reserve

Awards

Meritorious Unit Citation; Joint Meritorious Unit Award; Army Service Ribbon; National Defense Service Medal with Bronze Star Device; Army Commendation Medal; Armed Forces Reserve Medal with M device, Bronze Hourglass, and numeral 2 device;
Reserve Component Achievement Medal with 3 Oak Leaf Clusters; Global War on Terror Expeditionary Medal
Global War on Terror Medal; Afghanistan Campaign Medal; Expert-Small Arms; Combat Medical Badge; Overseas Service Bar;
82nd Airborne Combat Patch- 2002-2003 – 909th Forward Surgical Team; 44th Medical Command; 82nd Airborne Division;
FOB Salerno Afghanistan.

Other:

Invited Panelist: HLS C2 Prioritization Workshop/USAMRMC-TATRC. 27 April 2003,
Orlando, Florida. Gary P. Wratten Memorial Visiting Professor, 20 May 2003, San Antonio, Texas.
Invited Panelist: 10th Annual Trauma Symposium – Brooke Army Medical Center, 10 August 2004, San Antonio, Texas.
American Association for the Surgery of Trauma Honorary Combat Surgery Medal, 2004.
The Association of Military Surgeons-Texas Medical Center Chapter Faculty Advisor.
The University of Texas Center for Biosecurity and Public Health Preparedness-Associate Director, Hospital and Trauma Preparedness.

ACADEMIC APPOINTMENTS

1995-1996 Instructor of Pediatric Surgery
University of Michigan Medical School
1996-1997 Instructor of Pediatric Surgery
University of Texas-Houston Medical School
1997-2001 Assistant Professor of Surgery and Pediatrics
University of Texas-Houston Medical School
2001-2005 Associate Professor of Surgery and Pediatrics
University of Texas-Houston Medical School
2005-Present Professor of Surgery and Pediatrics
University of Texas-Houston Medical School
2005-Present Professor of Surgery
Center for Biomedical Engineering
Neuroscience Research Center
University of Texas-Houston Medical School

HOSPITAL APPOINTMENTS

Texas Children’s Hospital
Memorial Hermann Children’s Hospital
LBJ/Ben Taub General Hospitals
M.D. Anderson Cancer Center
1996-Present Co-Director UT-HMS/Hermann Hospital ECMO Program
1996-Present Director UT-HMS/Hermann Hospital Pediatric Trauma Program

LICENSURE

Texas
Michigan

Top of Page

BOARD CERTIFICATIONS

May 2, 1995 Diplomate, American Board of Surgery
April 20, 1998 Special Qualifications in Pediatric Surgery
Oct. 24, 1997 Added Qualifications in Surgical Critical Care
2003 Recertification in Surgery

OTHER CERTIFICATIONS

Advanced Trauma Life Support – Provider and Instructor
Basic Cardiac Life Support

PROFESSIONAL ORGANIZATIONS

Society of Critical Care Medicine
American Society for Artificial Internal Organs
American Pediatric Surgical Association
Texas Pediatric Surgical Society
American College of Surgeons
Association of Academic Surgery
American Association for the Surgery of Trauma
Society of University Surgeons
American Academy of Pediatrics
Surgical Biology Club III
Microcirculatory Society
Extracorporeal Life Support Organization
American Physiological Society-Cardiovascular Section

HONORS AND AWARDS

1984 Graduate, University of Texas Plan II Liberal Arts Honors Program
1986 Dean's List, University of Texas Medical Branch
1987 University of Texas Medical Branch at Galveston representative to American College of Surgeons Clinical Congress, Medical Student Program
1990 Resident Award, American College of Surgeons Committee on Trauma, South Texas Chapter Resident's Competition
1991 American Society of Artificial Internal Organs Traveling Fellowship Award
1992 Alpha Omega Alpha
1992 Resident Award, American College of Surgeons, South Texas Chapter
Scientific Session
1993 Co-winner Carl A. Moyer Award for Burn Research (American Burn Association)
1994 George W. Waldron Surgical Award (Outstanding Chief Resident, University of Texas Health Science Center at Houston)
1997 Dean’s Excellence Award, University of Texas Medical School-Houston
1998 Dean’s Excellence Award, University of Texas Medical School-Houston
2000 Physician of the Year – Memorial Hermann Children’s Hospital
2002 Charter Fellow, Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices
2002 Faculty Advisor – The Association of Military Surgeons of the United States: Texas Medical Center Chapter
2003 Microcirculatory Award for Excellence in Lymphatic Research
2006 William Pokorny Surgical Science Lectureship

EDITORIAL POSITIONS

Clinical Science - reviewer
Journal of Trauma - reviewer
Journal of Surgical Endoscopy - reviewer
Surgery - reviewer
Journal of Thoracic and Cardiovascular Surgery – reviewer
ASAIO Journal – Editorial Board: Gas Exchange/Pediatric Circulatory Support and Perfusion Sections

COMMITTEES

NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS

1998-Present State of Florida Emergency Medical Services Trauma Center Site Reviewer
2000-Present Reviewer, National Student Research Forum
2001-Present State of Missouri Department of Health Trauma Center Site Reviewer
2001-Present State of Pennsylvania Department of Health Trauma Center Site Reviewer
2002-2002 Canadian Institutes of Health Research: Cardiovascular Systems Study Section
2002-2002 US Civilian Research and Development Foundation Bilateral Grants Program-III
2002-Present State of Pennsylvania Trauma Systems – Site Reviewer
2000-2003 Society of University Surgeons: Chairman, local arrangements for 2003 meeting
2003-2003 Medical Advisory Council: Congress of the United States House of Representatives; 25th District, Texas
2003-Present Southeast Texas Regional Advisory Council – Pediatric Trauma Subcommittee Chairman
2004-2004 Centers for Disease Control Injury Center: Measurement of Quality Outcomes Work Group
2004-Present American College of Surgeons Southern Texas District #1 Committee on Applicants
2005-Present Society of University Surgeons Membership Committee
2005-Present Association of Academic Surgery: Fundamentals of Surgical Research Course Faculty
2005-Present National Medical Research Council (Singapore): Sepsis Study Section
2005-Present American Heart Association, Western Review Consortium - (Lung, Immunology, Surgery) Study Section
2006-Present American Heart Association, Western States Affiliate - Research Advisory Committee

THE UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON

Residency Advisory Council, Department of Surgery, University of Texas Health Science Center at Houston, 1993-1994.
House Officer Association Representative, University of Texas Health Science Center at Houston 1993-1994.
Faculty Senate, University of Texas Medical School-Houston 1996-1997; 2001-2002; 2004-2006.
ACGME Residency review committee for Department of Pediatrics, University of Texas Health Science Center at Houston, 1994.
Student Evaluation and Promotions Committee, 2001-Present.

UTHSC-H AFFILIATED HOSPITALS

1996-1998 Director-PAT for Pediatric Trauma Center Development (Hermann Hospital)
1996-Present Pediatric Operating Room Subcommittee (Hermann Hospital)
1996-1998 Pharmacy and Therapeutics Committee (Hermann Hospital)
1999-Present Medical Staff Peer Review Committee (Hermann Hospital)
2003-2005 Chair – Medical Staff Quality Assurance
2005-Present Co-Chair Pediatric Medical Staff Quality Assurance

SPONSORSHIP: POSTGRADUATE DEGREES

  1. Supervisor NIH Summer Study Medical Student S. Kim. Project: "Can a Hollow Fiber Membrane Filter remove Circulating Endotoxins during Extracorporeal Circulation?" - S.Kim (1991)
  2. Sponsor/mentor for Medical Student David Butler -NMF Squibb-Bristol Myers Scholarship-$8,000 (1999)
  3. Mentor for Laura Johnson, Neonatology Post-Doctoral Fellow
    “PMN priming by gut lymph after ECMO” (2000)
  4. Sponsor/mentor for medical student Jarrod Little – American Heart Association Cardiovascular Diseases Scholarship-$2,000 (2000)
  5. Supervisor: Jeff Padaleck: NIH Summer Study Medical Student; Project: “Does enteral feeding improve resuscitation induced ileus?” (2003)
  6. Sponsor/Mentor: Uwe Fischer, M.D. – Dr. F. Kohler Chemie GmbH Scholar
  7. Sponsor/Mentor: Henning Sauer, M.D. – Dr. F. Kohler Chemie GmbH Scholar

CURRENT TEACHING RESPONSIBILITIES

  1. Problem based learning instructor: Junior student surgery rotations.
  2. Oral examinations: Junior student surgery rotations.
  3. Surgery House Officer Clinical Teaching:
    Departmental Morbidity and Mortality
    Divisional Morbidity and Mortality
    Teaching rounds (patient care teaching)
    Intraoperative teaching (technical components of surgery)
    Pediatric house officer, clinical teaching – didactic lecture series
  4. Teaching of Surgical Tutorial for Senior Medical students 1997-1998
  5. Chairman CME course: “Pediatric Review and Update, 1998”, University of Texas-Houston Medical School
  6. Instructor: Pediatric Advanced Life Support (PALS)
  7. Instructor: Advanced Pediatric Life Support (APLS)
  8. Instructor: Hermann Hospital Life Flight cadaver procedure lab
  9. Pediatric Transport Team curriculum
  10. Instructor: Advanced Trauma Life Support (ATLS)
  11. Lecturer: Neonatal Fellows Conference: Surgical Problems of the Neonate
  12. Lecturer : ECMO Team Training Conference (Annual)
  13. The Center for Biomedical Engineering : University of Texas-Houston and MD Anderson Cancer Center

GRANT SUPPORT

CURRENT
  1. National Institutes of Health 1T32 GM 087-92-01: $1,181,532 – 2001-2009. NRSA Institutional Training Grant. Trauma Research Training Program. Support Faculty.
    Fellow – Stacey Moore-Olufemi, M.D.
    Fellow – Ravi Radhakrishnan, M.D.
  2. Congressional Mandated Program/United States Army Medical Research and Material Command. T5 (Texas Training and Technology Against Trauma and Terrorism); $524,758 – 2004-2008. Portable veno-venous rewarming for hypothermia. Principal Investigator.
  3. National Institutes of Health 1 R21 HD042659-01A1; $222,750 – 2003-2006.
    Multi-center Traumatic Brain Injury Network. Principal Investigator.
  4. National Institutes of Health P30 DK 56338; $10,000 – 2005-2006. Digestive Diseases Center Award – Pilot/Feasibility. Role of iNOS in Gut Edema Induced Ileus. Principal Investigator (Subcontract)
  5. National Institutes of Health 1 R01 NS 046308-01A1; $1,307,374 – 2004-2009. Academic Outcomes After Pediatric Traumatic Brain Injury. Co-Investigator. (Ewing-Cobbs)
  6. University of Texas Center for Biomedical Engineering/Charles W. Tate and Judy Spencer Tate Charitable Foundation; $20,000, 2005-2006. Engineering problems of portable biologic fluid warmers. Co-Principal Investigator (Gill).
  7. American Heart Association Grant-in-Aid; $124,000 – 2005-2007. Mechanisms of myocardial dysfunction after gut ischemia/reperfusion. Principal Investigator.
  8. University of Texas President’s Award; $1,600,000 – 2005-2007. Center for Engineered Microtherapeutics. Principal Investigator.
  9. Charles W. Tate and Judy Spencer Tate Charitable Foundation; $30,000 – 2006-2007. A System for Automated Field Tube Thoracostomy. Co-Principal Investigator (Gill).
  10. National Institutes of Health/NHLBI; $29,468.80 – 2006-2008. Production assistance for cellular therapies. Principal Investigator. (Subcontract)
  11. National Institutes of Health M01 RR 02558; $30,000 – 2006-2007. Safety of autologous stem cell treatment for traumatic brain injury in children. Principal Investigator.
PENDING
  1. National Institutes of Health 1K01 DK 070758; $515, 008 – 2005-2010. Effects of edema on cadherins in small intestine. Co-Sponsor (Uray)
  2. American Heart Association Beginning Grant-in-Aid; $62,000 – 2006-2008. Role of Stat-3 in edema induced intestinal dysfunction. Sponsor (Uray)
  3. DARPA: BAA 06-24 Subcontract; $421,231 – 2006-2008. Bone marrow progenitor cell therapy for blast induced TBI (Subcontract for: Characterization, mitigation and treatment of long term blast induced brain injury using a novel porcine model of chronic repetitive blast exposure. System Integrator: Cox (PI: Fossum-TAMU)
PAST
  1. Shriner’s Burns Institute: $288,444 - 1991-1994; Pathophysiology of ovine smoke inhalation injury treated with intravascular oxygenation and carbon dioxide removal device and intratracheal pulmonary ventilation. Co-Investigator. (Zwischenberger)
  2. Children’s Miracle Network Telethon Grant: $25,850, 1997-1998. Peripheral microvascular permeability in the systemic inflammatory response syndrome. Principal Investigator.
  3. Children’s Miracle Network Telethon Grant: $8,300, 1997-1998. Equipment funding for Pediatric lung injury and inflammation research group. Co-Principal Investigator. (Okhuysen)
  4. Merck KGaA: $125,500, 1999-2000. Effects of Na+/H+ exchange inhibition on cardiac function. Principal Investigator.
  5. National Highway Transportation Safety Administration: $50,000 – 1999-2001. Development of a pediatric functional capacity index. Consultant.
  6. University of Texas JSP grant $1,500 – 2000. Development of PMN superoxide assay. Principal Investigator.
  7. National Institutes of Health 1 K08 GM 00675-01: $596,430 – 1999-2005. Mentored Clinical Scientist Award. Microvascular injury during extracorporeal life support. Principal Investigator.
  8. United States Army Medical Research and Material Command/TATRC 04343002: $98,369 – 2004-2005. A portable fluid warming system. Co Principal Investigator. (Gill)

INVENTIONS/PATENTS/INTELLECTUAL PROPERTY

  1. Gill B, Cox CS. Ultrasound-guided catheter directed embolization for exsanguinating pelvic fractures (In Development).
  2. Cox CS, Gill B. A portable fluid warming system. (Patent Pending).
  3. Consultant: Gerson Lehrman Group: Council of Health Care Advisors, 2003-Present.
  4. Consultant: Vida Care, Intraosseous Infusion Device.
  5. Investigational New Drug: Safety of Autologous Mesenchymal Stem Cell Treatment for Pediatric TBI; FDA/CBER/OCTGT, BB-IND-12620, 2005.
  6. Alation, Inc., Principal Shareholder.

Top of Page

PUBLICATIONS

Abstracts
  1. Cox CS, James E, McClellan DG, Townsend CM, Thompson JC: Calmodulin antagonist trifluoperazine inhibits growth and survival of pancreatic cancer in vitro. Dig Dis Sci 1986; 31(10):1186. (Poster presentation)
  2. Cox CS, Zwischenberger JB, Traber LD, Traber DL, Herndon DN: Application of an intravenous mechanical blood oxygen/carbon dioxide exchange device (IVOX) for smoke inhalation injury in an ovine model. Cardiovascular Science and Technology: Basic and Applied, II 1:391, 1990.
  3. Wang CZ, Cox CS, Barrow RE, Herndon DN. Detergent induced change in pulmonary microvascular permeability. FASEB J 5:A769, 1991.
  4. Fleming RYD, Cox CS, Gore D, Honeycutt DA, Jahoor F, Wolfe RR, Herndon DN. Effect of propranolol on glucose uptake in hypermetabolic burned patients. Proc Am Burn Assoc, 124:125, 1992.
  5. Cox CS, Fleming RYD, Zwischenberger JB, Myers T., Kurusz M, Alison WE, Herndon DN. Ileal mucosal hypoperfusion during cardiopulmonary bypass. Crit Care Med 20:S64, 1992. (Poster presentation)
  6. Cox CS, Zwischenberger JB, Traber DL, Traber LD, Herndon, DN. Intravascular oxygenation/CO2 removal allows reduction of mechanical ventilation support in an ovine model of acute lung injury. Crit Care Med 20:S60, 1992. (Poster presentation)
  7. Cox CS, Zwischenberger JB, Graves D, Raymond G. Mortality from severe ARDS remains unchanged. Am Rev Resp Dis 145:A83, 1992. (Poster presentation)
  8. Cox CS, Zwischenberger JB, Graves D, Cardenas, V. Permissive hypercapnia with IVOX: A ventilation technique to reduce barotrauma. ASAIO Abstracts 21:65, 1992. (Poster presentation)
  9. Cox CS, Traber DL, Gasser H, Redl H, Schlag G, Herndon DN. Interleukin 6 levels in burned patients: Effect of inhalation injury. FASEB J 6:A2042, 1992. (Poster presentation)
  10. Cox CS, Zwischenberger JB, Traber DL, Traber LD, Haque AK, Herndon DN. Heparin improves oxygenation and minimizes barotrauma after severe smoke inhalation in an ovine model. Proc Am Burn Assoc 124:20, 1992. (Oral presentation)
  11. Cox CS, Zwischenberger JB, Traber LD, Traber DL, Herndon DN. Beneficial effects of heparin treatment of smoke inhalation injury not due to reduced oxygen free radical activity. Am Rev Resp Dis 145:A80, 1992. (Poster presentation)
  12. Zeigler ST, Cox CS, Meyer J, Traber DL, Herndon DN. The role of nitric oxide in the pulmonary pathophysiology of burn/sepsis. Am Rev Resp Dis A45:A313, 1992.
  13. Zwischenberger JB, Cox CS, Graves DF. Initial clinical experience with an intravascular oxygenator and carbon dioxide removal device (IVOX). Thorac Cardiovasc Surg 40:104, 1992.
  14. Meyer J, Cox CS, Traber DL, Nakazawa H, Herndon DN. Cardiopulmonary effects of heparin in endotoxemia. Circ Shock 37:40, 1992.
  15. Meyer J, Kramer GC, Cox CS, Traber DL, Nakazawa H, Herndon DN. Continuous small volume resuscitation with hypertonic saline/dextran solution improves survival in experimental sepsis. Circ Shock 39:12.49, 1993.
  16. Cox CS, Zwischenberger JB, Fleming RYD, Myers T, Kurusz M, Herndon DN, Kramer GC. Hypertonic saline-dextran does not improve regional perfusion in a porcine model of cardiopulmonary bypass. Proc Intl Conf on Hypertonic Resuscitation 5:4, 1992. (Oral presentation).
  17. Cox CS, Biondo N, Traber LD, Lentz CW, Herndon DN, Traber DL. Effects of superoxide dismutase (SOD) on pulmonary microvascular response to endotoxin. Proc Intl Endotoxin Society. 2:245, 1992. (Poster presentation)
  18. McDaniel LB, Cox CS, Zwischenberger JB, Kurusz M, Kramer GC. Effects of hypertonic saline dextran on intracranial pressure and brain water during CPB. Anesthesiology 77:A661, 1992.
  19. Nguyen TT, Herndon DN, Cox CS, Biondo N, Traber LD, Bush PE, Traber DL. Effects of MnSOD on lung fluid balance after smoke inhalation injury. Proc Am Burn Assoc 75:31, 1993.
  20. Nguyen TT, Cox CS, Fleming RYD, Traber DL, Gasser H, Redl H, Schlag G, Herndon DN. Free radical activity and loss of plasma antioxidants, Vitamin E, and sulfhydryl groups in burned patients. Proc Am Burn Assoc 75:146, 1993.
  21. Nguyen TT, Cox CS, Matheis E, Bush P, Traber DL, Herndon DN, Bidani A, Zwischenberger JB. Marked enhancement of carbon dioxide removal by second generation IVOX. ASAIO Abstracts, 1993.
  22. Nguyen TT, Cox CS, Tzounakis A, Bush P, Traber DL, Herndon DN, Bidani A, Zwischenberger JB. Carotid blood flow during permissive hypercapnia in an ovine model. Crit Care Med 21:S190, 1993.
  23. Zwischenberger JB, Nguyen T, Upp JR, Bush P, Cox CS, Delosh T., Broemling L. Complications of neonatal extracorporeal membrane oxygenation (ECMO): Experience from the Extracorporeal Life Support Organization. Proc Am Assoc Thorac Surg. (In Press)
  24. Nguyen TT, Zwischenberger JB, Cox CS, Bush P, Matheis E, Bidani A, Traber DL, Herndon DN. IVOX with permissive hypercapnia: A new management technique in an ovine smoke inhalation injury model. Proc Assoc Academic Surgery 27:136, 1993.
  25. Meyer J, Stothert JC, Pollard V, Potter R, Cox CS, Traber LD, Traber DL. Nitric oxide synthesis inhibition in ovine endotoxemia: Effects on brain blood flow. Anesth Analg 76:S264, 1993
  26. Reickert CA, Hirschl RB, Schumacher R, Geiger JD, Cox CS, Teitelbaum DH, Polley TZ, Harmon CM, Lelli JL, Coran AG. The effect of delayed repair of congenital diaphragmatic hernia on survival. Proc Central Surgical Association 53:73, 1996.
  27. Nguyen T, Cox CS, Biondo N, Traber LD, Herndon DN, Bush PE, Traber DL. Effects of superoxide dismutase on the pulmonary response to endotoxin. Circ Shock 39 (Suppl 2):36, 1993.
  28. Allen GS, Cox CS, Cocanour CS, Duke JH, Moore FA, Andrassy RJ. Pulmonary contusions: Are children different? Proc SW Surgical Congress. (In Press)
  29. Cox CS, Black CT, Duke JH, Cocanour CS, Moore FA, Lally KP, Andrassy RJ. Operative management of truncal vascular injuries in children and adolescents. Proc Pacific Assoc of Pediatr Surg 30:109, 1997. (Poster presentation)
  30. Allen GS, Cox CS, White NW, Khalil S, Rabb M, Lally KP. Postoperative respiratory complications in ex-premature infants after inguinal herniorrhaphy. Proc Am Acad Pediatrics 49:75, 1997.
  31. Allen GS, Moore FA, Cox CS, Wilson JT, Cohn JM, Duke JH. Hollow visceral injury in blunt trauma. J Trauma 43:196, 1997.
  32. Cox CS, Allen SJ, Brennan MS. Analysis of microvascular permeability with cardiopulmonary bypass. Proc Assoc Acad Surg. 32:252, 1998. (Poster presentation)
  33. Sauer H, Cox CS, Laine GA, deVivie ER, Frederick JR, Allen SJ. Effects of TBC 1269, a novel sialyl Lewisx selectin antagonist, on the coronary microvasculature during myocardial reperfusion in a dog model. Proc FASEB. (In Press)
  34. Cox CS, Allen SJ, Brennan M. Colloids minimize intestinal edema after ongoing resuscitation. Proc Am Assoc Surg Trauma, 1999.
  35. Neville H, Lally KP, Cox CS. Emergent abdominal decompression with patch abdominoplasty in the pediatric patient. Proc Can Assoc Pediatr Surg 31:34, 1999.
  36. Cox CS, Allen SJ, Butler D, Sauer H, Frederick J. Extracorporeal circulation exacerbates microvascular permeability after endotoxemia. J Surg Res 86:283, 1999. (Oral presentation)
  37. Gill BS, Neville HL, Khan AM, Cox CS, Lally, KP. Delayed Institution of ECMO increases morbidity in meconium aspiration syndrome. Proc ELSO 11:1, 2000.
  38. Mehall JR, Cook P, Andrassy RJ, Cox CS. Incidence of missed injuries in pediatric blunt trauma patients with GCS <9. J Trauma 52:197, 2002.
  39. Stewart R, Rohn D, Fischer U, Cox CS, Allen SJ, Criscione J, Laine GA.
    Alterations in cardiac and vascular function curves following resolution of acute myocardial edema. FASEB J 16:A1128, 2002
  40. Cox CS, Fischer U, Allen SJ. Is mesenteric lymph toxic to endothelial cells after mesenteric ischemia/reperfusion? FASEB J 16:A442, 2002.
  41. Fischer U, Cox CS, Mehlhorn U, deVive ER, Stewart RH, Laine GA, Allen SJ. Impact of acute myocardial edema on left ventricular function. FASEB J 16:A1128, 2002.
  42. Fischer U, Allen ST, Cox CS, Stewart RH, Laine GA, Allen SJ. Effect of chronic and acute myocardial edema on left ventricular interstitial pressure and chamber compliance. FASEB J 16:A1128, 2002
  43. Cox CS, Allen SJ, Murray M. Improved myocardial function using a
    Na+/H+ exchange inhibitor during cardioplegic arrest and cardiopulmonary bypass. Surg Forum 52:74-77, 2001. (Oral presentation)
  44. Blakely ML, Neville HL, Mehall J, Smith S, Warner BW, Mantor PC, Cox
    CS, Lally, KP. A Comparison of early versus late inguinal hernia repair in premature infants. Proc Pacific Assoc. Pediatr Surg 35:48, 2002.
  45. Cox CS, Fischer UM, Allen SJ, Laine GA. Mesenteric lymph diversion
    prevents myocardial edema and dysfunction after gut ischemia/reperfusion (I/R). Surg Forum 195:S82, 2002. (Oral presentation)
  46. Hassoun H, Fischer U, Allen SJ, Moore FA, Laine GA, Cox CS. Regional hypothermia reduces mucosal NF-K? DNA binding activity and PMN priming via gut lymph during mesenteric ischemia/reperfusion. J Surg Res 107:316, 2002.
  47. Cox CS, Allen SA, Fischer U, Xue H, Stewart R, Laine GL, Moore FA. Gut edema causes ileus. Crit Care Med 30:A148(590), 2002. (Poster presentation)
  48. Stewart R, Quick C, Criscione J, Cox CS, Allen S, Laine G. The effect of nitric oxide on lymphatic function depends on the axial pressure gradient. FASEB J 17:A128, 2003.
  49. Miller S, Thacker L, Raney RB, Andrassy RJ, Herzog C, Lally KP, Cox CS, Blakely ML. Long-term outcome of children and adolescents with tumors of fibrous etiology. Proc ASCO A3230 (www.asco.org/ac), 2003.
  50. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Allen SJ. Mild hypothermia impairs left ventricular diastolic but not systolic function. Thorac Cardiovasc Surg V192, 2003.
  51. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Allen SJ. Radical Scavenging with N-Acetylcysteine reduces oxidative stress and improves cardiac performance in dogs subjected to cardioplegic arrest. Thorac Cardiovasc Surg V57, 2003.
  52. Fischer UM, Cox CS, Allen SJ, Mehlhorn U, Bloch W, Laine GA. Rapid apoptosis signal pathway induction by cardioplegic arrest. FASEB J 17:A841, 2003.
  53. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Allen SJ. Acute myocardial edema does not impair left ventricular systolic function. Thorac Cardiovasc Surg V193, 2003.
  54. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Bloch W, Allen SJ. Detection of altered gene expression during cardioplegic arrest by means of DNA microarray. FASEB J 17:A844, 2003.
  55. Stewart RH, Quick C, Crisione JC, Cox CS, Allen SJ, Laine GA. Hypothermia inhibits lymphatic pumping. FASEB J 17:A128, 2003.
  56. Quick C, Stewart RH, Crisione JC, Cox CS, Allen SJ, Laine GA. Lymphangion pumping can decrease lymph flow in edema: preliminary model predictions. FASEB J 17:A129, 2003.
  57. Blakely ML, Cox CS, Mathews S, Andrassy RJ, Lally KP. Acute cardiac decompensation following patent ductus arteriosus (PDA) ligation in premature infants. Surg Forum 197:S49, 2003.
  58. Moore-Olufemi SD, Xue H, Stewart RH, Laine GA, Cox CS. Gut edema alters expression of tight junction proteins. Surg Forum 199:S39, 2004.
  59. Moore-Olufemi SD, Kozar RA, Moore FA, Hassoun HT, Sato N, Cox CS, Kone BC. Ischemic preconditioning protects against intestinal ischemia/reperfusion injury. Shock 21, Supplement 2:61, 2004.
  60. Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Inhibition of intestinal transit by resuscitation induced gut edema is reversed by administration of L-NIL. J Surg Res, 121:334, 2004.
  61. Harting MT, Lally KP, Cox CS, Lantin-Hermoso R, Blakely ML. Cardiac decompensation after patent ductus arteriosus ligation in premature infants. Proc Am Assoc Pediatr, 92-93, 2004.
  62. Blakely ML, Pereira KD, Cox CS, Matthews S, Lally KP. Prospective determination of the incidence of vocal cord paralysis after patent ductus arteriosus ligation. Proc Am Pediatr Surg Assoc, 35:A117, 2004.
  63. Uray K, Cox CS, Allen SJ, Laine GA. Coordinated changes in cadherin expression and contractility due to gut edema development in intestinal smooth muscle. Mol Biol Cell, Supplement 15:A2329, 2004.
  64. Uray KS, Allen SJ, Laine GA, Cox CS. Intestinal edema reduces intestinal motility through decreased myosin light chain phosphorylation. FASEB J, 19(4):A744, 2005.
  65. Harting MT, Blakely ML, Jaffe N, Cox CS, Hayes-Jordan AA, Benjamin RS, Andrassy RJ, Lally KP. Long term survival after aggressive resection of pulmonary metastases among children and adolescents with osteosarcoma. Proc Am Pediatr Surg Assoc, 36:A149, 2005.
  66. Moore-Olufemi SD, Padalecki J, Xue H, Radhakrishnan RS, Allen SJ, Stewart RH, Laine GA, Cox CS. Early enteral nutrition improves gut edema associated ileus. Surg Forum, 201:S32, 2005.
  67. Radhakrishnan R, Xue H, Moore FA, Allen SJ, Cox CS. Acute intestinal edema causes a decrease in stiffness and residual stress. Shock 23 (Supplement 3); 85:196, 2005.
  68. Khan A, Colasurdo J, Remington V, Rees M, Cox CS, Lally KP. The role of surfactant replacement during ECMO for surfactant dysfunction related to RSV bronchiolitis. Proc ELSO 16:44, 2005.
  69. Khan A, Remington V, Rees N, Hayes-Jordan A, Cox CS, Lally KP. Role of ECMO in the repair of traumatic tracheal stenosis. Proc ELSO 16:45, 2005.
  70. Radhakrishnan RS, Xue H, Weisbrodt NW, Moore FA, Allen SJ, Laine GA, Cox CS. Hypertonic saline reverses acute intestinal edema and improves transit through changes in cytoskeletal composition. J Surg Res 130:133, 2006.
  71. Radhakrishnan RS, Lally PA, Lally KP, Cox CS. ECMO for meconium aspiration syndrome: Support for relaxed entry criteria. ASAIO Journal. 52(2):66A, 2006.
  72. Radhakrishnan RS, Shah K, Xue H, Moore FA, Weisbrodt NW, Allen SJ, Gill BS, Cox CS. Minimally invasive measurement of intestinal edema using an impedance analyzer circuit. Gastroenterology 130(4 Suppl 2):A1-911, 2006.
  73. Moore-Olufemi SD, Lott S, Olufemi SE, Sato N, Kozar RA, Moore FA, Radhakrishnan RS, Cox CS, Kone BC. Transcriptional profiling of ischemic preconditioning in rat intestine following ischemia/reperfusion injury. Surg Forum. (In Press)
  74. Moore F, Mercer D, Kone B, Weisbrodt N, McKinley B, Dial E, Cox C, Kozar R, Gonzalez E, Robinson E, Moody FA. The role of the gut in multiple organ failure (MOF). Shock 25 (Suppl 1):12, 2006.
Refereed Original Articles in Journals
  1. Feldtman RW, Cox CS, Nirgiotis JT, Guajardo MA. Malignant fibrous histiocytoma arising from the superficial femoral artery. South Med J 85:219-220, 1992.
  2. Nirgiotis J, Cox CS, Feldtman RW. Atraumatic clostridium septicum infections. Complications in Surgery, 10:17-20, 1991.
  3. Cox CS, Zwischenberger JB, Traber LD, Traber DL, Herndon DN. Use of an intravascular oxygenator in an ovine model. Trans Am Soc Artif Intern Organs 37:M411 M414, 1991
  4. Cox CS, Zwischenberger JB, Kurusz M. Development and current status of a new intracorporeal membrane oxygenator (IVOX). Perfusion 6:291-296, 1991.
  5. Zwischenberger JB, Cox CS. A new intravascular membrane oxygenator for augmentation of blood gas transfer in patients with acute respiratory failure. Tex Med 87:60 63, 1991.
  6. Zwischenberger JB, Keeney S, Raymond G, Hanson M, Cox CS. Neonatal transport in Texas. Tex Med 88:66-69, 1992.
  7. Cox CS, Macris MP, Adams P. Late presentation of subclavian artery pseudoaneurysm. Clin Intens Care 2:288 291, 1991.
  8. Zwischenberger JB, Cox CS, Graves D, Bidani A. IVOX: A new application for permissive hypercapnia. Thorac Cardiovasc Surg 40:115-120, 1992.
  9. Cox CS, Zwischenberger JB, Traber DL, Traber LD, Haque AK, Herndon DN. Heparin improves oxygenation and minimizes barotrauma after severe smoke inhalation in an ovine model. Surg Gynecol Obstet 176:339-349, 1993.
  10. Zwischenberger JB, Cox CS. Extracorporeal Membrane Oxygenation for neonatal respiratory failure. Thorac Cardiovasc Surg, 40:316-322, 1992.
  11. Meyer J, Cox CS, Nakazawa H, Herndon DN, Traber DL. Cardiopulmonary effects of heparin in experimental endotoxemia. Crit Care Med 21:84-89, 1993.
  12. Cox CS, Zwischenberger JB, Traber DL, Minifee PK, Traber LD, Herndon DN. Immediate positive pressure ventilation with positive end-expiratory pressure (PEEP) improves survival in ovine smoke inhalation injury. J Trauma 33:821-827, 1992.
  13. Cox CS, Zwischenberger JB, Fleming RYD, Alison WE, Myers T, Kurusz M, Herndon DN, Kramer GC. Ileal mucosal hypoperfusion during cardiopulmonary bypass. Curr Surg 49:507-509, 1992.
  14. Zwischenberger JB, Cox CS, Minifee PK, Traber DL, Traber LD, Flynn JT, Linares HA, Herndon DN. Pathophysiology of ovine smoke inhalation injury treated with extracorporeal membrane oxygenation. Chest 103:1582-1586, 1993.
  15. Cox CS, Zwischenberger JB, Graves D, Niranjan S, Bidani A. Intracorporeal CO2 removal and permissive hypercapnia to reduce airway pressure in acute respiratory failure: The theoretical basis for permissive hypercapnia with IVOX. ASAIO Trans 39:97-102, 1993.
  16. Zwischenberger JB, Nguyen T, Upp Jr JR, Bush P, Cox CS, DeLosh T, Broemling L. Complications of neonatal extracorporeal membrane oxygenation (ECMO): Collective experience from the Extracorporeal Life Support Organization. J Thorac Cardiovasc Surg. 107:838-849, 1994.
  17. Wang CZ, Barrow RE, Cox CS, Yang Y, Herndon DN. Increased pulmonary microvascular permeability induced by aerosolized detergent. J Appl Physiol 74:1016-1023, 1993.
  18. Nguyen TT, Cox CS, Herndon DN, Biondo N, Traber LD, Bush PE, Traber DL. Effects of MnSOD on lung fluid balance after smoke inhalation injury. J Appl Physiol 78:2161-2168, 1995.
  19. Nguyen TT, Cox CS, Traber DL, Gasser H, Redl H, Schlag G, Herndon DN. Free radical activity and loss of plasma antioxidants, vitamin E, and sulfhydryl groups in burned patients. J Burn Care and Rehab 14:604-609, 1993.
  20. Zwischenberger JB, Nguyen TT, Tao W, Bush PE, Cox CS, Traber DL, Herndon DN, Bidani A. IVOX with gradual permissive hypercapnia: A new management technique for respiratory failure. J Surg Res 57:99-105, 1994.
  21. Reickert CA, Hirschl RB, Schumacher R, Geiger JD, Cox CS, Teitelbaum DH, Polley TZ, Harmon CM, Lelli JL, Coran AG. The effect of delayed repair of congenital diaphragmatic hernia on survival. Surgery 120:766-773, 1996.
  22. Krupnik AS, Teitelbaum DH, Geiger JD, Strouse PJ, Cox CS, Blane CA, Polley TZ. Use of abdominal ultrasound to assess pediatric splenic trauma: Potential pitfalls in the diagnosis. Ann Surg 225:408-414, 1997.
  23. Decker RA, Geiger JD, Cox CS, Mackovjak M, Sarkar M, Peacock ML. Prophylactic surgery for MEN 2a following genetic diagnosis: Is parathyroid transplantation indicated? World J Surg 20:814-821, 1996.
  24. Cox CS, Geiger JD, Liu DC, Garver K. Pediatric solid organ injury after blunt trauma: Role of computed tomography contrast blush. J Pediatr Surg 32:1196-1200, 1997.
  25. Teitelbaum DH, Cox CS. Simplified insertion of a transpyloric feeding tube. Am J Surg 174:351-352, 1997.
  26. Cox CS, Black CT, Duke JH, Cocanour CS, Moore FA, Lally KP, Andrassy RJ. Operative management of truncal vascular injuries in children and adolescents. J Pediatr Surg 33:462-467, 1998.
  27. Allen GS, Cox CS, Cocanour CS, Duke JH, Moore FA, Andrassy RJ. Pulmonary contusions: Are children different? J Am Coll Surg 185:229-233, 1997.
  28. Allen GS, Cox CS, White NW, Khalil S, Rabb M, Lally KP. Postoperative respiratory complications in ex-premature infants after inguinal herniorrhaphy. J Pediatr Surg 33:1095-1098, 1998.
  29. Allen GS, Moore FA, Cox CS, Wilson JT, Cohn JM, Duke JH. Hollow visceral injury in blunt trauma. J Trauma 45:69-78, 1998.
  30. Cox CS, Allen GS, Cocanour CS, Conklin LD, Duke JD, Moore FA. Blunt versus penetrating subclavian artery injury: Presentation, injury pattern, and outcome. J Trauma 46:445-449, 1999.
  31. Allen GS, Cox CS. Pulmonary contusion in children: Diagnosis and management. South Med J 91:1099-1106, 1998.
  32. Allen GS, Moore FA, Cox CS, Mehall JR, Duke JH. Delayed diagnosis of blunt duodenal injury: An avoidable complication. J Am Col Surg 187:393-9, 1998.
  33. Cox CS, Allen SJ, Brennan MS. Analysis of microvascular permeability with cardiopulmonary bypass. J Surg Res 83:19-26, 1999.
  34. Neville H, Lally KP, Cox CS. Emergent abdominal decompression with patch abdominoplasty in the pediatric patient. J Pediatr Surg 35:705-708, 2000.
  35. Cox CS, Brennan M, Allen SJ. Impact of hetastarch on the intestinal microvascular barrier during ECLS. J Appl Physiol 88:1374-1380, 2000.
  36. Cox CS, Allen SJ, Sauer H, Frederick J. Effects of selectin – sialyl LewisX blockade on microvascular permeability associated with cardiopulmonary bypass. J Thorac Cardiovasc Surg 119:1255-61, 2000.
  37. Cox CS, Allen SJ, Butler D, Sauer H, Frederick J. Extracorporeal circulation exacerbates microvascular permeability after endotoxemia. J Surg Res 91:50-55, 2000.
  38. Gill BS, Neville HL, Khan AM, Cox CS, Lally KP. Delayed institution of extracorporeal membrane oxygenation is associated with increased mortality rate and prolonged hospital stay. J Pediatric Surg 37:7-10, 2002.
  39. Cox CS, Sauer H, Allen SJ, Buja LM, Laine GA. Sodium/Hydrogen exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass. An Experimental Study. J Thorac Cardiovasc Surg 123:959-966, 2002.
  40. Cox CS, Allen SJ, Sauer H, Laine GA. Improved myocardial function using a Na+/H+ exchanger inhibitor (EMD 87580) during cardioplegic arrest and cardiopulmonary bypass. Chest 123:187-194, 2003.
  41. Sauer H, Allen ST, Cox CS, Laine GA. Effect of Sialyl Lewisx-Selectin blockade on myocardial protection during cardioplegic arrest and reperfusion. The Heart Surgery Forum 4(3):216-222, 2001.
  42. Chwals WJ, Cheng A, Neville HL, Blakely ML, Lally PA, Andrews RL, Cox CS, Lally KP. Surgery associated complications in necrotizing enterocolitis (NEC): a multi-institutional study. J Pediatr Surg 36:1722-1724, 2001.
  43. Cox CS, Sauer H, Allen S, Laine G. Myocardial performance after cardiopulmonary bypass and cardioplegic arrest: Impact of a Na+/H+ -exchanger inhibitor. J Invest Surg 15:1-8, 2002.
  44. Stewart RH, Allen SJ, Rohn DA, Allen SJ, Quick CM, Cox CS, Laine GA.
    Effects of venous air embolization on pulmonary microvascular protein permeability. Microcirculation 11:409-414, 2004
  45. Cox CS, Fischer UM, Allen SA, Laine G. Lymphatic diversion prevents myocardial edema after mesenteric ischemia-reperfusion. Microcirculation 11:1-8, 2004.
  46. Hassoun H, Fischer UM, Allen SJ, Moore FA, Laine GA, Cox CS. Regional hypothermia reduces mucosal NFKB DNA binding activity and PMN priming via gut lymph during mesenteric ischemia/reperfusion. J Surg Res 115:121-128, 2003.
  47. Fischer UM, Cox CS, Stewart RH, Mehlhorn U, Allen SJ, Laine GA. The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest. J Thorac Cardiovasc Surg 126:1483- 1488, 2003.
  48. Balogh Z, McKinley BA, Cocanour SC, Kozar RA, Cox CS, Moore FA. Patients with impending abdominal compartment syndrome do not respond to early volume loading. Am J Surg 186:602-608, 2003.
  49. Balogh Z, McKinley BA, Cox CS, Allen SJ, Cocanour CS, Kozar RA, Miller CC Weisbrodt NW, Moore FA. Abdominal Compartment Syndrome: a modifiable link between traumatic shock and multiple organ failure. Shock 20:483-492, 2003
  50. Moore-Olufemi SD, Xue H, Attuwaybi BO, Fischer UM, Harari Y, Oliver DH, Weisbrodt NW, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Resuscitation-induced gut edema and intestinal dysfunction. J Trauma 58:264-270, 2005.
  51. Moore-Olufemi SD, Kozar RA, Moore FA, Sato N, Hassoun HT, Cox CS, Kone BC. Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury. Shock 23:258-263, 2005.
  52. Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Effects of primary and secondary intraabdominal hypertension on mesenteric lymph flow: Implications for the abdominal compartment syndrome. Shock 23:571-575, 2005.
  53. Radhakrishnan R, Xue H, Weisbrodt N, Moore FA, Allen SJ, Laine GA, Cox CS. Resuscitation induced intestinal edema decreases the stiffness and residual stress of intestine. Shock 24:165-170, 2005.
  54. Harting MT, Doherty D, Lally KP, Andrews WM, Cox CS. Modified pyloric exclusion for infants with complex duodenal injuries. Pediatr Surg Int 21:569-572, 2005.
  55. Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Inhibition of intestinal transit by resuscitation-induced gut edema is reversed by L-NIL. J Surg Res 129:1-5, 2005.
  56. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Allen SJ. Mild hypothermia impairs left ventricular diastolic but not systolic function. J Invest Surg 18:291-296, 2005.
  57. Harting MT, Blakely ML, Jaffe N, Cox CS, Hayes-Jordan AA, Benjamin RS, Andrassy RJ, Lally KP. Long-term survival after aggressive resection of pulmonary metastases among children and adolescents with osteosarcoma. J Pediatr Surg 41:194-199, 2006.
  58. Fischer UM, Cox CS, Stewart RH, Laine GA, Allen SJ. Impact of acute myocardial edema on left ventricular function. J Invest Surg 19:31-38, 2006.
  59. Hayes-Jordan AA, Doherty DK, West SD, Raney RB, Blakely ML, Cox CS, Andrassy RJ, Lally KP. Outcome following surgical resection of recurrent rhabdomyosarcoma. J Pediatr Surg 41:633-638, 2006.
  60. Stewart RH, Quick CM, Zawieja DC, Cox CS, Allen SJ, Laine GA. Pulmonary air embolization inhibits lung lymph flow by increasing lymphatic outflow pressure. Lymphatic Research and Biology 4:18-22, 2006.
  61. Radhakrishnan RS, Xue H, Weisbrodt NW, Moore FA, Allen SJ, Laine GA, Cox CS. Hypertonic saline resuscitation prevents hydrostatically-induced intestinal edema and ileus. Crit Care Med 34:1713-1718, 2006.
  62. Ewing-Cobbs L, Prasad MR, Kramer L, Cox CS Jr, Baumgartner J, Fletcher S, Mendez D, Barnes M, Zhang X, Swank P.Late intellectual and academic outcomes following traumatic brain injury sustained during early childhood. J Neurosurg;105(4 Suppl):287-96, 2006.
  63. Uray K, Laine GA, Xue H, Allen SJ, Cox CS. Intestinal edema decreases intestinal contractile activity by decreasing myosin light chain phosphorylation. Crit Care Med;34(10):2630-7, 2006.
  64. Pereira KD, Webb BD, Blakely ML, Cox CS, Lally KP. Sequelae of recurrent laryngeal nerve injury after patent ductus arteriosus ligation. Int J Pediatr Otorhinolaryngol;70(9):1609-12, 2006.
  65. Radhakrishnan RS, Lally PA, Lally KP, Cox CS. ECMO for meconium aspiration syndrome: Support for relaxed entry criteria. ASAIO Journal. 53(4):489-91, 2007.
  66. Radhakrishnan RS, Shah K, Xue H, Moore-Olufemi SD, Moore FA, Weisbrodt NW, Allen SJ, Gill B, Cox CS Jr. Measurement of intestinal edema using an impedence analyzer circuit. J Surg Res;138(1):106-10, 2007.
  67. Radhakrishnan RS, Radhakrishnan HR, Xue H, Moore-Olufemi SD, Mathur AB, Weisbrodt NW, Moore FA, Allen SJ, Laine GA, Cox CS Jr. Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Crit Care Med;35(2):538-43, 2007.
  68. Uray KS, Laine GA, Xue H, Allen SJ, Cox CS Jr. Edema-induced intestinal dysfunction is mediated by STAT3 activation. Shock;28(2):239-44, 2007.
  69. Harting MT, Jimenez F, Cox CS Jr.The pulmonary first-pass effect, xenotransplantation and translation to clinical trials--a commentary.Brain;131(Pt 8):e100; 2008.
  70. Harting MT, Jimenez F, Kozar RA, Moore FA, Mercer DW, Hunter RL, Cox CS Jr, Gonzalez EA. Effects of poloxamer 188 on human PMN cells.Surgery;144(2):198-203, 2008.
  71. Ewing-Cobbs L, Prasad MR, Swank P, Kramer L, Cox CS Jr, Fletcher JM, Barnes M, Zhang X, Hasan KM. Arrested development and disrupted callosal microstructure following pediatric traumatic brain injury: relation to neurobehavioral outcomes.Neuroimage. 2008 Jul 4. [Epub ahead of print]
  72. Harting MT, Blakely ML, Cox CS Jr, Lantin-Hermoso R, Andrassy RJ, Lally KP.Acute hemodynamic decompensation following patent ductus arteriosus ligation in premature infants.J Invest Surg;21(3):133-8, 2008.
  73. Fischer UM, Radhakrishnan RS, Uray KS, Xue H, Cox CS Jr.Myocardial Function After Gut Ischemia/Reperfusion: Does NFkappaB Play a Role? J Surg Res. 2008 May 5. [Epub ahead of print]
  74. Harting MT, Jimenez F, Cox CS.Isolation of mesenchymal stem cells (MSC) from green fluorescent protein positive (GFP+) transgenic rodents: The grass is not always green(er).Stem Cells Dev. 2008 Jun 2. [Epub ahead of print]
  75. Fischer UM, Gill BS, Aroom K, Fogle L, Xue H, Cox CS Jr.Portable arteriovenous rewarming for hypothermia: cardiovascular considerations. ASAIO J;54(3):278-83, 2008.
  76. Paulozzi LJ, Cox CS, Williams DD, Nolte KB.John and Jane Doe: the epidemiology of unidentified decedents.J Forensic Sci;53(4):922-7, 2008.
  77. Radhakrishnan RS, Radhakrishnan GL, Radhakrishnan HR, Xue H, Adams SD, Moore-Olufemi SD, Harting MT, Cox CS Jr, Kone BC.PRETREATMENT WITH BONE MORPHOGENETIC PROTEIN-7 (BMP7) MIMICS ISCHEMIA PRECONDITIONING (IPC) FOLLOWING INTESTINAL ISCHEMIA/REPERFUSION (IR) INJURY IN THE INTESTINE AND LIVER.Shock. 2008 May 2. [Epub ahead of print]
  78. Harting M, Jimenez F, Pati S, Baumgartner J, Cox C Jr.Immunophenotype characterization of rat mesenchymal stromal cells.Cytotherapy;10(3):243-53, 2008.
  79. Cox CS Jr, Radhakrishnan R, Villarrubia L, Xue H, Uray K, Gill BS, Stewart RH, Laine GA.Hypertonic saline modulation of intestinal tissue stress and fluid balance.Shock;29(5):598-602, 2008.
  80. Desai KV, Laine GA, Stewart RH, Cox CS Jr, Quick CM, Allen SJ, Fischer UM.Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema.Am J Physiol Heart Circ Physiol;294(6):H2428-34, 2008.
  81. Harting MT, Baumgartner JE, Worth LL, Ewing-Cobbs L, Gee AP, Day MC, Cox CS Jr.Cell therapies for traumatic brain injury.Neurosurg Focus;24(3-4):E18, 2008.
  82. Stewart RH, Uray K, Cox CS, Laine GA.Myocardial fluid balance in dogs with naturally acquired heartworm infection.Am J Vet Res;69(3):356-61, 2008.
  83. Dongaonkar RM, Quick CM, Stewart RH, Drake RE, Cox CS Jr, Laine GA.Edemagenic gain and interstitial fluid volume regulation.Am J Physiol Regul Integr Comp Physiol;294(2):R651-9, 2008.
Invited Articles in Journals
  1. Zwischenberger JB, Cox CS. Staging and surgery for lung cancer. J Thorac Imaging 7:57-69, 1991.
  2. Zwischenberger JB, Cox CS. Extracorporeal membrane oxygenation in the management of cardiac failure. ASAIO Trans 38, 751-753, 1992.
  3. Boyars M, Zwischenberger JB, Cox CS. Clinical manifestations of pulmonary fungal infections. J Thorac Imaging 7:12-22, 1992.
  4. Lentz CW, Traber DL, Zeigler ST, Cox CS, Herndon DL, Traber LD. Cytokine response to injury. In Shock, Sepsis and Organ Failure, Third Annual Bernard Wiggers Conference, eds G. Schlag, H Redl, JH Siegel, DL Traber. Springer-Verlag, New York, NY, pp 245-264, 1993.
  5. Beech TR, Cox CS, Lally KP. Current management of congenital diaphragmatic hernia. Curr Surg 50:44-47, 1993.
  6. Cox CS, Zwischenberger JB, Traber DL, Herndon DN. Effect of heparin on smoke induced lung injury: A review of potential mechanisms of action in Saliba, M. ed., The effects of heparin in the treatment of burns, San Diego, CA, pp.74-83, 1993.
Book Chapters
  1. Zwischenberger JB, Cox CS: Extracorporeal Membrane Oxygenation Emergencies, In Arensman R, Cornish D (ed): Extracorporeal Life Support. Boston, Blackwell Scientific, pp. 207-225, 1993.
  2. Zwischenberger JB, Cox CS: Extracorporeal Membrane Oxygenation Emergencies, In Arensman R, Cornish D (ed): Extracorporeal Life Support. Boston, Blackwell Scientific, pp. 207-225, 1993.
  3. Allison P, Cox CS, Cornish D, Zwischenberger JB: Management of Complications in Extracorporeal Membrane Oxygenation, in Cornish D, et al (ed): Extracorporeal Life Support Organization Manual. Ann Arbor, pp. 128-142, 1993.
  4. Cox CS, Zwischenberger JB, Traber DL, Herndon DN: Cardiovascular Function in Acute Burns, in Schlag G and Redl H (eds): Pathophysiology of Shock, Sepsis, and Multi Organ Failure. New York, Springer-Verlag, pp. 242-256, 1993.
  5. Traber DL, Lentz CW, Cox CS, Herndon DN: Thermal Injury, in Mortillaro NA and Taylor AE (eds): Pathophysiology of the Microcirculation, Boca Raton, CRC Press, Inc., 35:171-198, 1994.
  6. Zwischenberger JB, Cox CS: Extracorporeal Membrane Oxygenation (ECMO) for Neonatal Respiratory Failure, in Fraedrich, Hasse, Schlosser (eds): Kardiotechnik 1992 Berlin, Steinkopff, Verlag, Darmstadt, pp. 37-42, 1992.
  7. Zwischenberger JB, Cox CS: Intracorporeal Membrane Oxygenation and Carbon Dioxide Removal, in Fraedrich, Hasse, Schlosser (eds): Kardiotechnik 1992. Berlin, Steinkopff, Verlag, Darmstadt, pp. 1-12, 1992.
  8. Cox CS, Lally KP, Marvin R, Weber T, Andrassy RH: Physiologic problems in the Pediatric Surgical Patient, in Miller TA (ed.): Modern Surgical Care, Physiologic Foundations and Clinical Applications. St. Louis, Quality Medical Publishing, pp. 1337-1361, 1998.
  9. Cox CS, Lally KP: Congenital and Pediatric Anorectal Conditions, in Beck DE and Wexner SD (eds.): Fundamentals of Anorectal Surgery. London, W. B. Saunders Company, pp. 54-69, 1998.
  10. Cox CS, Lally KP: Systemic inflammatory response and extracorporeal life support, in Zwischenberger JB and Bartlett RB (eds): Extracorporeal Life Support. Extracorporeal Life Support Organization, pp. 161-182, 2000.
  11. Lally KP, Cox CS, Andrassy RJ: Appendicitis, in Townsend CM (ed): Textbook of Surgery (16th edition), New York, W. B. Saunders Company, pp. 917-928, 2000.
  12. Neville H, Cox CS: Cystic hygroma, in: Zevitz M (ed): EMedicine: Surgery (1st edition), www.emedicine.com/ped/
  13. Neville H., Cox CS: Hirschsprung’s disease, in: Zevitz M (ed): Emedicine: Surgery (1st edition), www.emedicine.com/ped/topic1010.htm
  14. Cox CS: Neonatal Jaundice, in: Toy EC, Liu TH, (ed): Case Files in General Surgery, McGraw-Hill/Lange Medical Books, New York, pp. 499-506, 2004.
  15. Lally KP, Cox CS, Andrassy RJ: Appendicitis, in: Townsend CM (ed): Textbook of Surgery (17th edition), New York, Elsevier Saunders Company, pp. 1381-1399, 2004.
  16. Radhakrishnan R, Cox CS: Systemic inflammatory response and extracorporeal life support, in: Lally KP and Van Meurs K (ed): Extracorporeal Life Support. Extracorporeal Life Support Organization (4th edition), pp. 59-83, 2005.
  17. Cox CS: Child Abuse, in: Wesson D (ed): Pediatric Trauma. WB Saunders, New York, pp. 73-82, 2006.
  18. Hayes-Jordan AA, Cox CS, Lally KP: Advanced Therapy in Surgical Oncology, in: Pollock RE, Curley EA, Ross MI, Perrier ND (ed): BC Decker, Hamilton, Ontario, Canada. (In Press – 2007)
Films

Coran AG, Cox CS. Partial gastric transposition for esophageal atresia as a primary procedure. American College of Surgeons Clinical Congress Video presentation, 1996.

Letters-to-the-Editor
  1. Cox CS. Epiphenomenology of feeding access of the neurologically impaired child. Pediatrics 100:899, 1997.
  2. Cox CS. Same day ileostomy closure. Not for children! Am J Man Care 3:1444, 1997.
  3. Cox CS. Heparin for smoke inhalation injury. Crit Care Med 31:1291, 2003.
Presentations (Invited)
  1. "Hemostasis, Coagulation and Blood Surface Interactions during ECMO", University of Texas Medical Branch at Galveston, ECMO Training Course, Galveston, Texas, 10/19/90.
  2. "Respiratory Assist Devices: Future Trends", University of Texas Medical Branch at Galveston, Galveston, Texas, 12/12/90.
  3. "Extracorporeal membrane oxygenation (ECMO) and Intravascular Oxygenation for Acute Respiratory Failure in an Ovine Model", University of Texas Health Science Center at Houston Surgical Research Symposium, Houston, Texas, 6/1/91.
  4. "Acute Respiratory Failure", Shriners Burns Institute Basic Science Lecture Series, Galveston, Texas, 10/25/91.
  5. "ECMO for neonatal and pediatric respiratory failure", Houston Area Respiratory Care Conference, Houston, Texas, 8/5/92.
  6. "Pathophysiology of smoke inhalation injury", University of Texas Health Science Center at Houston, Houston, Texas, 10/25/92.
  7. "New treatments of smoke inhalation injury", University of Texas Health Science Center at Houston, Houston, Texas, 6/24/94.
  8. “Pediatric Shock Update”, University of Texas Health Science Center at Houston, 7/7/97.
  9. “Pediatric Trauma: ABC’s-Abuse, Burns and Closed Head injury”, Hermann Life Flight Roseann Waindell Memorial Emergency Care Symposium. 8/13/96.
  10. “Oxygen Kinetics of ECMO”, University of Texas Medical School-Houston-ECMO and Neonatal Transport Course, Houston, Texas, 7/23/97.
  11. “Venoarterial and Venovenous ECMO”, University of Texas Medical School-Houston-ECMO and Neonatal Transport Course, Houston, Texas, 7/24/97.
  12. “ECMO Cannulation”, University of Texas Medical School-Houston-ECMO and Neonatal Transport Course, 10/25/00.

Top of Page

Presentations (Scientific; not represented by abstracts)
  1. "Malignant fibrous histiocytoma arising from the superficial femoral artery", San Antonio Vascular Surgery Society, San Antonio, Texas, 9/29/89. (Oral)
  2. "Subclavian Artery Trauma", American College of Surgeons Committee on Trauma Meeting, Dallas, Texas, 11/2/90. (Oral)
  3. "Consumptive Coagulopathy during ECMO?”, Extracorporeal Life Support Organization, Ann Arbor, Michigan, 11/30/90. (Poster)
  4. "Use of an Intravascular Oxygenator in an Ovine Smoke Inhalation Injury Model", Society of University Surgeons, Galveston, Texas, 2/7/91. (Resident's Program) (Oral)
  5. "Mechanical and Patient Complications of Extracorporeal membrane oxygenation for respiratory failure", Ninth Biomedical Engineering Research Conference, Houston, Texas, 2/12/91. (Oral)
  6. "Airtrapping capability of the SCIMED Ectotherm heat exchanger", Extracorporeal Life Support Organization Meeting, Ann Arbor, Michigan, 9/12/91. (Poster/Device Demonstration)
  7. "Heparin improves oxygenation and minimizes barotrauma after smoke inhalation in an ovine model", American College of Surgeons, So. TX. Ch. Meeting, San Antonio, Texas, 2/17/92. (Oral)
  8. "Ileal mucosal hypoperfusion during cardiopulmonary bypass", Society of University Surgeons, Cincinnati, Ohio, 2/15/92. (Resident's Program) (Oral)
  9. "Intratracheal pulmonary ventilation - a new technique of mechanical ventilation”, Biomedical Engineering Research Meeting, Houston, Texas, 3/19/92. (Oral)
  10. "Reduction of ventilator support with IVOX", Biomedical Engineering Research Meeting, Houston, Texas, 3/19/92. (Oral)
  11. "Effects of heparin on smoke-induced pulmonary injury: A review of potential mechanisms of action”, University of California, San Diego; Effects of heparin in burns Meeting, San Diego, California, 2/25/94. (Oral)
  12. "Heparin and experimental sepsis", University of California, San Diego; Effects of heparin in burns Meeting, San Diego, California, 2/25/94. (Oral)
  13. “Surgical management of ambiguous genitalia: An update”, University of Oklahoma, Pediatric Surgery Resident’s Conference, Oklahoma City, Oklahoma, 11/15/95. (Oral)
  14. “Blunt versus penetrating subclavian artery injury: Presentation, injury pattern, and outcome”, American Association for Surgery of Trauma, Waikoloa, Hawaii, 9/25/97. (Poster)
  15. “Imaging and decision making in pediatric blunt abdominal trauma”, University of Texas-Houston Medical School Department of Surgery Grand Rounds, Houston, Texas, 11/24/97. (Oral)
  16. “Fundamentals of Pediatric Trauma Resuscitation”, University of Texas-Houston Medical School Department of Surgery Grand Rounds, Houston, Texas, 1/20/97. (Oral)
  17. “PMN mediated microvascular injury with extracorporeal circulation”, Rice University Bioengineering Seminar, Houston, Texas 9/15/99. (Oral).
  18. “Evaluation of Pediatric Blunt Abdominal Trauma”, East Texas Medical Conference Continuing Medical Education/Grand Rounds, Tyler, Texas, 5/19/00. (Oral)
  19. “ECMO for Trauma-Related Cardiopulmonary Failure”, East Texas Medical Conference Continuing Medical Education/Grand Rounds, Tyler, Texas, 5/19/00. (Oral)
  20. “Evaluation of Pediatric Blunt Abdominal Trauma”, Trauma Regional Advisory Council V Symposium, South Padre Island, Texas, 6/15/00. (Oral)
  21. “Update on Smoke Inhalation Injury”, Southeast Texas Trauma Regional Advisory Council, Houston, Texas, 7/10/00. (Oral)
  22. “Decision making in Pediatric Blunt Abdominal Trauma”, Southeast Memorial Hospital Grand Rounds, Houston, Texas, 9/16/00. (Oral)
  23. “Management of Pediatric Blunt Abdominal Trauma”, Valley Baptist Medical Center, Harlingen, Texas, 12/7/00. (Oral)
  24. “Unconventional adjuncts to mechanical ventilation in ARDS”, American College of Surgeons, New Orleans, Louisiana 10/11/01. www.facs.org/clinical2001/cox.pdf (Oral)
  25. “Intestinal edema – effect on function”, Red Duke Professorship Day, University of Texas – Houston, Houston, Texas, 1/15/02. (Oral)
  26. “Pediatric Trauma Resuscitation”, East Texas Medical Center Trauma Symposium, Tyler Texas, 08/23/02. (Oral).
  27. “Trauma Surgery in Afghanistan”, Valley Baptist Medical Center, Harlingen, Texas, 3/25/03. (Oral)
  28. “Terror in Afghanistan”, University of Texas-Houston Grand Rounds, Houston, Texas, 4/01/03. (Oral)
  29. “A Semester Abroad”, University of Chicago Grand Rounds, Chicago, Illinois, 5/22/03. (Oral)
  30. “Pediatric Trauma: Relevance for the Military Surgeon”, Gary Wratten Memorial Surgical Conference, San Antonio, Texas, 5/20/03. (Oral)
  31. “Fluid Balance and ECMO”, Extracorporeal Life Support Organization, Chicago, Illinois, 9/13/03. (Oral-Plenary)
  32. “Military Surgery as a Reservist”, Surgical Student Association, Houston, Texas, 10/4/03.
  33. “Pediatric Surgery in a Combat Zone”, Department of Pediatrics Grand Rounds, Houston, Texas, 12/7/03. (Oral)
  34. “AMEDD Recruiting Strategies”, AMEDD Advertising and Marketing Workshop, Louisville, Kentucky, 4/12/04. (Oral)
  35. “Military Medical Careers”, Joint Admission Medical Program, University of Texas-Houston Medical School, Houston, Texas, 6/25/04. (Oral)
  36. “Pediatric Trauma Management: FST or Tertiary Trauma Center”, BAMC 10th Annual Trauma Symposium, San Antonio, Texas, 8/10/04. (Oral)
  37. “Mechanisms of Myocardial Dysfunction after Gut Ischemia/Reperfusion.” Red Duke Professorship Day, University of Texas-Houston, Houston, Texas, 1/22/05. (Oral)
  38. “Immune Function During ECMO”, Arnold G. Coran, M.D. Symposium, University of Michigan, Ann Arbor, Michigan, 6/5/05. (Oral)
  39. "Thoracic Trauma”, Cook Children’s Hospital Trauma Symposium, Fort Worth, Texas, 6/10/05. (Oral)
  40. “Dynamic Fluid Flow Modeling of an Arteriovenous Resuscitation Device”, UTCBME Symposium, 4/29/05. (Poster)
  41. “Bioimpedance Analysis Quantifies Level of Edema and Capacitance of Rat Small Intestine”, UTCBME Symposium, 7/29/05. (Poster)
  42. State of the Art Presentations: Meconium Aspiration - “ECMO for MAS – Do we use the right criteria?” Extracorporeal Life Support Organization Meeting, 9/17/05. (Oral-Panel)
  43. “Development of Stem-Cell Therapy for Brain Injury”, University of Texas-Houston Medical School, Houston, Texas, 10/28/05. (Oral)
  44. “Bone-marrow Progenitor Cells and Traumatic Brain Injury”, South Texas Chapter of the American College of Surgeons, Houston, Texas, 2/24/06. (Oral)
  45. “Cellular Therapy for Traumatic Brain Injury”, Pediatric Brain Injury Research Symposium, University of Texas Southwestern Medical School, Dallas, Texas, 3/31/06. (Oral)
  46. “Human Umbilical Cord Blood as Cellular Progenitor Therapy for Brain Injury”, Cord Blood Stem Cell Advisory Meeting, Tucson, Arizona, 4/6/06. (Oral)
  47. “Trauma and Child Abuse”, University of Texas Child Abuse Symposium, Houston, Texas, 5/12/06.

Top of Page

Faculty Biography

Charles Cox Jr, MD
  • Charles Cox Jr, MD
    Children's Fund Distinguished Professor and Director of the Pediatric Trauma Program at Children's Memorial Hermann Hospital
  • Department of Pediatric Surgery
  • University of Texas Medical School at Houston
    6431 Fannin Street, MSB 5.246
    Houston, TX 77030
  • phone: (713) 500-7307
    fax: (713) 500-7296
    e-mail: Charles.S.Cox@uth.tmc.edu
  • Coordinator,
    Special Programs: Crystal Sutton

  • Research Interests

  • Translational Laboratories